Sarolaner

Sarolaner (brand name Simparica) is an ectoparasiticide veterinary drug for the treatment of flea and tick infestations in dogs.[1][2] It is also used off-label to control sarcoptic mange and demodectic mange.[2]

Sarolaner
Clinical data
Trade namesSimparica
Other namesPF-6450567
ATCvet code
Identifiers
IUPAC name
  • 1-[6-[(5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard100.234.000
Chemical and physical data
FormulaC23H18Cl2F4N2O5S
Molar mass581.36 g·mol−1
3D model (JSmol)
SMILES
  • CS(=O)(=O)CC(=O)N1CC2(C1)OCc1cc(C3=NO[C@@](c4cc(Cl)c(F)c(Cl)c4)(C(F)(F)F)C3)ccc12
InChI
  • InChI=1S/C23H18Cl2F4N2O5S/c1-37(33,34)9-19(32)31-10-21(11-31)15-3-2-12(4-13(15)8-35-21)18-7-22(36-30-18,23(27,28)29)14-5-16(24)20(26)17(25)6-14/h2-6H,7-11H2,1H3/t22-/m0/s1
  • Key:FLEFKKUZMDEUIP-QFIPXVFZSA-N

Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. It is used for prevention of heartworm disease caused by Dirofilaria immitis; treat and prevent flea infestations; treat and control tick infestations with the lone star tick, Gulf Coast tick, American dog tick, black-legged tick, and brown dog tick; and treat and control roundworm and adult hookworm infections.[3]

Sarolaner is also an ingredient in feline combination antiparasitic Revolution Plus (known as Stronghold Plus in some countries), which contains sarolaner and selamectin and is used for prevention of sarcoptic mange, feline hookworms, feline roundworms, ear mites, and heartworms, as well as treating and preventing fleas and ticks. Sarolaner is in the formulation to kill fleas, ear mites, and ticks.[4]

References
  1. McTier TL, Chubb N, Curtis MP, Hedges L, Inskeep GA, Knauer CS, et al. (May 2016). "Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs" (PDF). Veterinary Parasitology. 222: 3–11. doi:10.1016/j.vetpar.2016.02.019. PMID 26961590.
  2. Gollakner R. "Sarolaner". vcahospitals.com. VCA Hospitals. Retrieved June 26, 2021.
  3. "FDA Approves Simparica Trio, a Combination Drug for Heartworm and Other Parasites". Food and Drug Administration. March 2, 2020. Retrieved June 26, 2021.
  4. "About Revolution Plus". www.zoetisus.com. Retrieved 2022-05-27.
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