Urofollitropin

Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified[1] to remove various proteins and other substances. FSH is important in the development of follicles (eggs) produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility.[2] It is also used with in vitro fertilization methods. The dosage is adjusted to each individual's response.[2]

Urofollitropin
Clinical data
Trade namesBravelle, Fertinex
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration		Subcutaneous, intramuscular
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
  • none
UNII
KEGG
ChEMBL
ECHA InfoCard100.212.030
Chemical and physical data
FormulaC975H1513N267O304S26
Molar mass22672.95 g·mol−1
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The most common side effects are abdominal or pelvic pain, bloating, as well as redness, pain or swelling at the injection site. Follitropin is possibly associated with increased risk of endometrial carcinoma. It is not for use during pregnancy, as there is evidence for birth defects under follitropin treatment.[2]

Bravelle sold in the United States from March 2014 through October 2015 is subject to a recall and refund by its maker, Ferring Pharmaceuticals, because certain batches of the medicine had a lower strength than stated.[3]

References
  1. van Wely M, Yding Andersen C, Bayram N, van der Veen F (2005). "Urofollitropin and ovulation induction". Treatments in Endocrinology. 4 (3): 155–65. doi:10.2165/00024677-200504030-00004. PMID 15898821. S2CID 26069210.
  2. Drugs.com: Urofollitropin (Intramuscular route, Subcutaneous route, Injection route)
  3. Enforcement Report - Week of October 21, 2015, Food and Drug Administration
  • Bravelle, by Ferring Pharmaceuticals, Switzerland
  • Fostimon by Institut Biochemique SA, Switzerland
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