Lewisite

Lewisite[1]
Names
Preferred IUPAC name
[(E)-2-Chloroethen-1-yl]arsonous dichloride
Other names
2-chloroethenyldichloroarsine
2-chlorovinyldichloroarsine
chlorovinylarsine dichloride
dichloro(2-chlorovinyl)arsine
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
MeSH lewisite
PubChem CID
UNII
UN number 2810
InChI
  • InChI=1S/C2H2AsCl3/c4-2-1-3(5)6/h1-2H/b2-1+ checkY
    Key: GIKLTQKNOXNBNY-OWOJBTEDSA-N checkY
  • InChI=1/C2H2AsCl3/c4-2-1-3(5)6/h1-2H/b2-1+
    Key: GIKLTQKNOXNBNY-OWOJBTEDBF
SMILES
  • Cl[As](Cl)\C=C\Cl
Properties
Chemical formula
 C2H2AsCl3
Molar mass 207.32 g/mol
Density 1.89 g/cm3
Melting point −18 °C (0 °F; 255 K)
Boiling point 190 °C (374 °F; 463 K)
Vapor pressure 0.58 mmHg (25 °C)
Hazards
NFPA 704 (fire diamond)
4
1
1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)
Infobox references

Lewisite (L) is an organoarsenic compound. It was once manufactured in the U.S., Japan, Germany[2] and the Soviet Union[3] for use as a chemical weapon, acting as a vesicant (blister agent) and lung irritant. Although the substance is colorless and odorless in its pure form, impure samples of lewisite are a yellow, brown, violet-black, green, or amber oily liquid with a distinctive odor that has been described as similar to geraniums.[4][5]

Chemical reactions

The compound is prepared by the addition of arsenic trichloride to acetylene in the presence of a suitable catalyst:

AsCl3 + C2H2 → ClCHCHAsCl2 (Lewisite)

Lewisite, like other arsenous chlorides, hydrolyses in water to form hydrochloric acid and chlorovinylarsenous oxide (a less-powerful blister agent):[5]

ClCHCHAsCl2 + 2 H2O → ClCHCHAs(OH)2 + 2 HCl

This reaction is accelerated in alkaline solutions, and forms acetylene and trisodium arsenate.[5]

Lewisite reacts with metals to form hydrogen gas. It is combustible, but difficult to ignite.[5]

Mechanism of action

Lewisite is a suicide inhibitor of the E3 component of pyruvate dehydrogenase. As an efficient method to produce ATP, pyruvate dehydrogenase is involved in the conversion of pyruvate to acetyl-CoA. The latter subsequently enters the TCA cycle. Peripheral nervous system pathology usually arises from Lewisite exposure as the nervous system essentially relies on glucose as its only catabolic fuel.[6]

Lewisite (top row) and mustard gas test with concentrations from 0.01% to 0.06%

It can easily penetrate ordinary clothing and latex rubber gloves. Upon skin contact it causes immediate stinging, burning pain and itching that can last for 24 hours. Within minutes, a rash develops and the agent is absorbed through the skin. Large, fluid-filled blisters (similar to those caused by mustard gas exposure) develop after approximately 12 hours and cause pain for 2–3 days.[4][5] These are severe chemical burns and begin with small blisters in the red areas of the skin within 2–3 hours and grow worse, encompassing the entire red area, for the ensuing 12–18 hours after initial exposure. Liquid lewisite has faster effects than lewisite vapor.[5] Sufficient absorption can cause deadly liver necrosis.

Those exposed to lewisite can develop refractory hypotension (low blood pressure) known as Lewisite shock, with some features of arsenic toxicity.[7] Lewisite damages capillaries, which then become leaky, reducing blood volume required to maintain blood pressure, a condition called hypovolemia. When the blood pressure is low, the kidneys may not receive enough oxygen and can be damaged.[5]

Inhalation, the most common route of exposure, causes burning pain and irritation throughout the respiratory tract, nosebleed (epistaxis), laryngitis, sneezing, coughing, vomiting, difficult breathing (dyspnea), and in severe cases of exposure, can cause fatal pulmonary edema, pneumonitis, or respiratory failure. Ingestion results in severe pain, nausea, vomiting, and tissue damage.[4][5] The results of eye exposure can range from stinging, burning pain and strong irritation to blistering and scarring of the cornea, along with blepharospasm, lacrimation, and edema of the eyelids and periorbital area. The eyes can swell shut, which can keep the eyes safe from further exposure. The most severe consequences of eye exposure to lewisite are globe perforation and blindness.[5] Generalised symptoms also include restlessness, weakness, hypothermia and low blood pressure.

It is possible that Lewisite is carcinogenic: arsenic is categorized as a respiratory carcinogen by the International Agency for Research on Cancer, though it has not been confirmed that lewisite is a carcinogen.[8]

Lewisite causes damage to the respiratory tract at levels lower than the odor detection threshold. Early tissue damage causes pain.[5]

Hydrolysis leads to chlorovinylarsonous acid, CVAA.

Treatment

British anti-lewisite, also called dimercaprol, is the antidote for lewisite. It can be injected to prevent systemic toxicity, but will not prevent injury to the skin, eyes, or mucous membranes. Chemically, dimercaprol binds to the arsenic in lewisite. It is contraindicated in those with peanut allergies.[5]

Other treatment for lewisite exposure is primarily supportive. First aid of lewisite exposure consists of decontamination and irrigation of any areas that have been exposed. Other measures can be used as necessary, such as airway management, assisted ventilation, and monitoring of vital signs. In an advanced care setting, supportive care can include fluid and electrolyte replacement. Because the tube may injure or perforate the esophagus, gastric lavage is contraindicated.[5]

Long-term effects

From one acute exposure, someone who has inhaled lewisite can develop chronic respiratory disease; eye exposure to lewisite can cause permanent visual impairment or blindness.[5]

Chronic exposure to lewisite can cause arsenic poisoning (due to its arsenic content) and development of a lewisite allergy. It can also cause long-term illnesses or permanent damage to organs, depending on where the exposure has occurred, including conjunctivitis, aversion to light (photophobia), visual impairment, double vision (diplopia), tearing (lacrimation), dry mucous membranes, garlic breath, burning pain in the nose and mouth, toxic encephalopathy, peripheral neuropathy, seizures, nausea, vomiting, chronic obstructive pulmonary disease (COPD), bronchitis, dermatitis, skin ulcers, basal cell carcinoma, and squamous cell carcinoma.[5]

Chemical composition

Lewisite can be a mixture of molecules with a different number of vinylchloride groups on the arsenic chloride: lewisite itself (2-chlorovinylarsonous dichloride), along with bis(2-chlorovinyl)arsinous chloride (lewisite 2) and tris(2-chlorovinyl)arsine (lewisite 3).[9] In addition, there are sometimes isomeric impurities: lewisite itself is mostly trans-2-chlorovinylarsonous dichloride, but the cis stereoisomer and the constitutional isomer (1-chlorovinylarsonous dichloride) may also be present.[10]

Experimental and computational studies both find that the trans-2-chloro isomer is the most stable, and that the carbon–arsenic bond has a conformation in which the lone pair on the arsenic is approximately aligned with the vinyl group.[10]

History

Lewisite identification poster from World War II.

Lewisite was synthesized in 1904 by Julius Arthur Nieuwland during studies for his PhD.[11][12][13] In his thesis, he described a reaction between acetylene and arsenic trichloride, which led to the formation of lewisite.[14] Exposure to the resulting compound made Nieuwland so ill he was hospitalized for several days.[12]

Lewisite is named after the US chemist and soldier Winford Lee Lewis (1878–1943).[15] In 1918, John Griffin, Julius Arthur Nieuwland's thesis advisor, drew Lewis's attention to Nieuwland's thesis at Maloney Hall, a chemical laboratory at The Catholic University of America, Washington D.C.[16] Lewis then attempted to purify the compound through distillation but found that the mixture exploded on heating until it was washed with HCl.[16]

Lewisite was developed into a secret weapon at a facility located in Cleveland, Ohio (The Cleveland Plant) at East 131st Street and Taft Avenue,[15][17] and given the name "G-34", which had previously been the code for mustard gas, in order to confuse its development with mustard gas.[18] On November 1, 1918, production began at a plant in Willoughby, Ohio.[19] It was not used in World War I, but Britain experimented with it in the 1920s as the "Dew of Death".[20]

After World War I, the US became interested in lewisite because it was not flammable. Up until World War II, it had the military symbol of "M1", after which it was changed to "L". Field trials with lewisite during World War II demonstrated that casualty concentrations were not achievable under high humidity, due to the rate of hydrolysis and the characteristic odor of the chemical, and lacrymation forced troops to don masks and avoid contaminated areas. The United States produced about 20,000 tons of lewisite, keeping it on hand primarily as an antifreeze for mustard gas, or to penetrate protective clothing in special situations.

Lewisite was replaced by the mustard gas variant HT (a 60:40 mixture of sulfur mustard and O-Mustard), and was declared obsolete in the 1950s. Lewisite poisoning can be treated effectively with British anti-lewisite (dimercaprol). Most stockpiles of lewisite were neutralised with bleach and dumped into the Gulf of Mexico.[21] Some remained at the Deseret Chemical Depot located outside Salt Lake City, Utah,[22] but, as of January 18, 2012, all U.S stockpiles had been destroyed.

Producing or stockpiling lewisite was banned by the Chemical Weapons Convention. When the convention entered force in 1997, the parties declared world-wide stockpiles of 6,747 tonnes of lewisite. As of December 2015, 98% of the stockpiles had been destroyed.[23]

In 2001, lewisite was found in a World War I weapons dump in Washington, D.C.[24]

Controversy over Japanese deposits of lewisite in China

In mid-2006, China and Japan were negotiating disposal of stocks of lewisite in northeastern China, left by Japanese military during World War II. People had died over the preceding twenty years from accidental exposure to these stockpiles.[25]

See also

  • Blue Cross (chemical warfare)

References

  1. ↑ Lewisite I - Compound Summary, PubChem.
  2. ↑ Mitchell, Jon (27 July 2013). "A drop in the ocean: the sea-dumping of chemical weapons in Okinawa" – via Japan Times Online.
  3. ↑ "Russia Completes Destruction of First 10 Tons of Lewisite - Analysis - NTI". www.nti.org.
  4. 1 2 3 U.S. National Research Council, Committee on Review and Evaluation of the Army Non-Stockpile Chemical Materiel Disposal Program (1999). Disposal of Chemical Agent Identification Sets. National Academies Press. p. 16. ISBN 0-309-06879-7.
  5. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 "CDC - The Emergency Response Safety and Health Database: Blister Agent: LEWISITE (L) - NIOSH". www.cdc.gov. Retrieved 2016-01-14.
  6. ↑ Berg, J.; Tymoczko, J. L.; Stryer, L. (2007). Biochemistry (6th ed.). New York: Freeman. pp. 494–495. ISBN 978-0-7167-8724-2.
  7. ↑ Chauhan, S.; Chauhan, S.; D’Cruz, R.; Faruqi, S.; Singh, K. K.; Varma, S.; Singh, M.; Karthik, V. Chemical warfare agents. Environ. Toxicol. Pharmacol. 2008, 26, 113-122
  8. ↑ Doi, M.; Hattori, N.; Yokoyama, A.; Onari, Y.; Kanehara, M.; Masuda, K.; Tonda, T.; Ohtaki, M.; Kohno, N. Effect of Mustard Gas Exposure on Incidence of Lung Cancer: A Longitudinal Study. American Journal of Epidemiology 2011, 173, 659-666.
  9. ↑ McNutt, Patrick M.; Tracey L., Hamilton (2015). "Ocular toxicity of chemical warfare agents". Handbook of Toxicology of Chemical Warfare Agents. Academic Press. pp. 535–555.
  10. 1 2 Urban, Joseph J.; von Tersch, Robert L. (1999). "Conformational analysis of the isomers of lewisite". J. Phys. Org. Chem. 12 (2): 95–102. doi:10.1002/(SICI)1099-1395(199902)12:2<95::AID-POC91>3.0.CO;2-V.
  11. ↑ Julius Arthur Nieuwland (1904) Some Reactions of Acetylene, Ph.D. thesis, University of Notre Dame (Notre Dame, Indiana).
  12. 1 2 Vilensky, J. A. (2005). Dew of Death - The Story of Lewisite, America's World War I Weapon of Mass Destruction. Indiana University Press. p. 4. ISBN 0253346126.
  13. ↑ Vilensky, J. A.; Redman, K. (2003). "British Anti-Lewisite (Dimercaprol): An Amazing History". Annals of Emergency Medicine. 41 (3): 378–383. doi:10.1067/mem.2003.72. PMID 12605205.
  14. ↑ Vilensky, J. "Father Nieuwland and the 'Dew of Death'".
  15. 1 2 "Deadliest Poison Discovered By An American". Early County News. May 29, 1919. p. 7. Retrieved July 30, 2020.
  16. 1 2 Vilensky, J. A. (2005). Dew of Death - The Story of Lewisite, America's World War I Weapon of Mass Destruction. Indiana University Press. pp. 21–23. ISBN 0253346126.
  17. ↑ Upton native's role was the best defense; WWI masks thwarted Archived December 18, 2007, at the Wayback Machine
  18. ↑ Joel A. Vilensky, Dew of Death: The Story of Lewisite, America's World War I Weapon of Mass Destruction (Bloomington, Indiana: Indiana University Press, 2005), page 36.
  19. ↑ Vilensky, J. A. (2005). Dew of Death - The Story of Lewisite, America's World War I Weapon of Mass Destruction. Indiana University Press. p. 50. ISBN 0253346126.
  20. ↑ Tabangcura, D. Jr.; Daubert, G. P. "British anti-Lewisite Development". Molecule of the Month. University of Bristol School of Chemistry.
  21. ↑ Code Red - Weapons of Mass Destruction Online Resources; - Blister Agents
  22. ↑ "Commander: World is safer with chemical stockpile gone".
  23. ↑ Organisation for the Prohibition of Chemical Weapons (30 November 2016). "Annex 3". Report of the OPCW on the Implementation of the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction in 2015 (Report). p. 42. Retrieved 8 March 2017.
  24. ↑ Tucker, J. B. (2001). "Chemical weapons: Buried in the backyard" (PDF). Bulletin of the Atomic Scientists. 57 (5): 51–56. doi:10.2968/057005014.
  25. ↑ Abandoned Chemical Weapons (ACW) in China Archived 2012-03-05 at the Wayback Machine
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