Upper respiratory tract infection

Upper respiratory tract infection
Conducting passages.
SpecialtyInfectious disease
MedicationHoney[1]
Frequency17.2 billion (2015)[2]
Deaths3,100[3]

Upper respiratory tract infection (URTI) is an illness caused by an acute infection, which involves the upper respiratory tract, including the nose, sinuses, pharynx, or larynx.[4]

This commonly includes rhinitis, sore throat, tonsillitis, pharyngitis, laryngitis, sinusitis, otitis media, and the common cold.[5] Most infections are viral in nature, and in other instances, the cause is bacterial.[6] URTIs can also be fungal or helminthic in origin, but these are less common.[7]

Honey appears to help symptoms more than usual care.[1] In 2015, 17.2 billion cases of URTIs are estimated to have occurred.[2] As of 2014, they caused about 3,000 deaths, down from 4,000 in 1990.[8]

Signs and symptoms

Time line for cold symptoms

In uncomplicated colds, coughing and nasal discharge may persist for 14 days or more even after other symptoms have resolved.[6] Acute URTIs include rhinitis, pharyngitis/tonsillitis, and laryngitis often referred to as a common cold, and their complications: sinusitis, ear infection, and sometimes bronchitis (though bronchi are generally classified as part of the lower respiratory tract.) Symptoms of URTIs commonly include cough, sore throat, runny nose, nasal congestion, headache, low-grade fever, facial pressure, and sneezing.

Symptoms of rhinovirus in children usually begin 1–3 days after exposure. The illness usually lasts 7–10 more days.[6]

Color or consistency changes in mucous discharge to yellow, thick, or green are the natural course of viral URTI and not an indication for antibiotics.[6]

Group A beta-hemolytic streptococcal pharyngitis/tonsillitis (strep throat) typically presents with a sudden onset of sore throat, pain with swallowing, and fever. Strep throat does not usually cause runny nose, voice changes, or cough.

Pain and pressure of the ear caused by a middle-ear infection (otitis media) and the reddening of the eye caused by viral conjunctivitis are often associated with URTIs.

Mouth

Small round red lesions may occur on the soft palate.[9] Decongestants may also cause decreased saliva.[9]

Cause

In terms of pathophysiology, rhinovirus infection resembles the immune response. The viruses do not cause damage to the cells of the upper respiratory tract, but rather cause changes in the tight junctions of epithelial cells. This allows the virus to gain access to tissues under the epithelial cells and initiate the innate and adaptive immune responses.[10]

Up to 15% of acute pharyngitis cases may be caused by bacteria, most commonly Streptococcus pyogenes, a group A streptococcus in streptococcal pharyngitis ("strep throat").[11] Other bacterial causes are Streptococcus pneumoniae, Haemophilus influenzae, Corynebacterium diphtheriae, Bordetella pertussis, and Bacillus anthracis.

Sexually transmitted infections have emerged as causes of oral and pharyngeal infections.[12]

Diagnosis

URI, seasonal allergies, influenza: symptom comparison
Symptoms Allergy URI Influenza
Itchy, watery eyes Common Rare (conjunctivitis may occur with adenovirus) Soreness behind eyes, sometimes conjunctivitis
Nasal discharge Common Common[6] Common
Nasal congestion Common Common Sometimes
Sneezing Very common Very common[6] Sometimes
Sore throat Sometimes (post-nasal drip) Very common[6] Sometimes
Cough Sometimes Common (mild to moderate, hacking)[6] Common (dry cough, can be severe)
Headache Uncommon Rare Common
Fever Never Rare in adults, possible in children[6] Very common
100–102 °F (or higher in young children), lasting 3–4 days; may have chills
Malaise Sometimes Sometimes Very common
Fatigue, weakness Sometimes Sometimes Very common (can last for weeks, extreme exhaustion early in course)
Muscle pain Never Slight[6] Very common (often severe)

Classification

A URTI may be classified by the area inflamed. Rhinitis affects the nasal mucosa, while rhinosinusitis or sinusitis affects the nose and paranasal sinuses, including frontal, ethmoid, maxillary, and sphenoid sinuses. Nasopharyngitis (rhinopharyngitis or the common cold) affects the nares, pharynx, hypopharynx, uvula, and tonsils generally. Without involving the nose, pharyngitis inflames the pharynx, hypopharynx, uvula, and tonsils. Similarly, epiglottitis (supraglottitis) inflames the superior portion of the larynx and supraglottic area; laryngitis is in the larynx; laryngotracheitis is in the larynx, trachea, and subglottic area; and tracheitis is in the trachea and subglottic area.

Prevention

Low- or very-low quality evidence indicates probiotics may be better than placebo in preventing acute URTIs.[13] Vaccination against influenza viruses, adenoviruses, measles, rubella, Streptococcus pneumoniae, Haemophilus influenzae, diphtheria, Bacillus anthracis, and Bordetella pertussis may prevent them from infecting the URT or reduce the severity of the infection.

Treatment

Treatment comprises symptomatic support usually via pain medications for headache, sore throat, and muscle aches.[14] Honey appears to help symptoms more than usual care.[1]

Moderate exercise in sedentary subjects with a naturally acquired URTI probably does not alter the overall severity and duration of the illness.[15] No randomized trials have been conducted to ascertain benefits of increasing fluid intake.[16]

Antibiotics

Prescribing antibiotics for laryngitis is not a suggested practice.[17] The antibiotics penicillin V and erythromycin are not effective for treating acute laryngitis.[17] Erythromycin may improve voice disturbances after a week and cough after 2 weeks, but any modest subjective benefit is not greater than the adverse effects, cost, and the risk of bacteria developing resistance to the antibiotics.[17] Health authorities have been strongly encouraging physicians to decrease the prescribing of antibiotics to treat common URTIs because antibiotic usage does not significantly reduce recovery time for these viral illnesses.[17] A 2017 systematic review found three interventions which were probably effective in reducing antibiotic use for acute respiratory infections: C-reactive protein testing, procalcitonin-guided management, and shared decision-making between physicians and patients.[18] The use of narrow-spectrum antibiotics has been shown to be just as effective as broad-spectrum alternatives for children with acute bacterial URTIs, and has a lower risk of side effects in children.[19] Decreased antibiotic usage could also have prevented drug-resistant bacteria. Some have advocated a delayed antibiotic approach to treating URTIs, which seeks to reduce the consumption of antibiotics while attempting to maintain patient satisfaction. A Cochrane review (updated 2017) of 11 studies and 3,555 participants explored antibiotics for respiratory tract infections. It compared delaying antibiotic treatment to either starting them immediately or to no antibiotics. Outcomes were mixed depending on the respiratory tract infection; symptoms of acute otitis media and sore throat were modestly improved with immediate antibiotics with minimal difference in complication rate. Antibiotic usage was reduced when antibiotics were only used for ongoing symptoms and maintained patient satisfaction at 86%.[20]

For sinusitis while at the same time discouraging overuse of antibiotics the CDC recommends:

  • Target likely organisms with first-line medications: amoxicillin, amoxicillin/clavulanate
  • Use the shortest effective course; should see improvement in 2–3 days. Continue treatment for 7 days after symptoms improve or resolve (usually a 10–14 day course).
  • Consider imaging studies in recurrent or unclear cases; some sinus involvement is frequent early in the course of uncomplicated viral URI[6]

Cough medicine

No good evidence exists for or against the effectiveness of over-the-counter cough medications for reducing coughing in adults or children.[21] Children under 2 years old should not be given any type of cough or cold medicine due to the potential for life-threatening side effects.[22] In addition, according to the American Academy of Pediatrics, the use of cough medicine to relieve cough symptoms should be avoided in children under 4 years old, and the safety is questioned for children under 6 years old.[23]

Decongestants

A single dose of nasal decongestant by mouth in the common cold is modestly effective for the short-term relief of congestion in adults; however, data on the use of decongestants in children are insufficient. Therefore, decongestants are not recommended for use in children under 12 years of age with the common cold.[24] Oral decongestants are also contraindicated in patients with hypertension, coronary artery disease, and history of bleeding strokes.[25][26]

Mucolytics

Mucolytics such as acetylcysteine and carbocystine are widely prescriped for upper and lower respiratory tract infection without chronic broncho-pulmonary disease. However, in 2013 a Cochrane review reported their efficacy to be limited.[27] Acetylcystine is considered to be safe for the children older than 2 years.[27]

Alternative medicine

Routine supplementation with vitamin C is not justified, as it does not appear to be effective in reducing the incidence of common colds in the general population.[28] The use of vitamin C in the inhibition and treatment of upper respiratory infections has been suggested since the initial isolation of vitamin C in the 1930s. Some evidence exists to indicate that it could be justified in persons exposed to brief periods of severe physical exercise and/or cold environments.[28] Given that vitamin C supplements are inexpensive and safe, people with common colds may consider trying vitamin C supplements to assess whether they are therapeutically beneficial in their case.[28]

Some low-quality evidence indicates the use of nasal irrigation with saline solution may alleviate symptoms in some people.[29] Also, saline nasal sprays can be of benefit.

Epidemiology

Children typically have two to nine viral respiratory illnesses per year.[6] In 2013, 18.8 billion cases of URTIs were reported.[30] As of 2014, they caused about 3,000 deaths, down from 4,000 in 1990.[8] In the United States, URTIs are the most common infectious illness in the general population, and are the leading reasons for people missing work and school.

Upper respiratory infections deaths per million persons in 2012
  0
  1
  2
  3–29
Disability-adjusted life year for URTIs per 100,000 inhabitants in 2002.[31]
  no data
  less than 10
  10–30
  30–60
  60–90
  90–120
  120–150
  150–180
  180–210
  210–240
  240–270
  270–300
  more than 300

See also

References

  1. 1 2 3 Abuelgasim, Hibatullah; Albury, Charlotte; Lee, Joseph (18 August 2020). "Effectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysis". BMJ Evidence-Based Medicine: bmjebm–2020–111336. doi:10.1136/bmjebm-2020-111336.
  2. 1 2 Vos, Theo; Allen, Christine; Arora, Megha; Barber, Ryan M.; Bhutta, Zulfiqar A.; Brown, Alexandria; Carter, Austin; Casey, Daniel C.; Charlson, Fiona J.; Chen, Alan Z.; Coggeshall, Megan; Cornaby, Leslie; Dandona, Lalit; Dicker, Daniel J.; Dilegge, Tina; Erskine, Holly E.; Ferrari, Alize J.; Fitzmaurice, Christina; Fleming, Tom; Forouzanfar, Mohammad H.; Fullman, Nancy; Gething, Peter W.; Goldberg, Ellen M.; Graetz, Nicholas; Haagsma, Juanita A.; Hay, Simon I.; Johnson, Catherine O.; Kassebaum, Nicholas J.; Kawashima, Toana; Kemmer, Laura (October 2016). "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1545–1602. doi:10.1016/S0140-6736(16)31678-6. PMC 5055577. PMID 27733282.
  3. ↑ GBD 2015 Mortality and Causes of Death, Collaborators (October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. doi:10.1016/s0140-6736(16)31012-1. PMC 5388903. PMID 27733281.
  4. ↑ Barlow, Gavin; Irving, William L.; Moss, Peter J. (2020). "20. Infectious disease". In Feather, Adam; Randall, David; Waterhouse, Mona (eds.). Kumar and Clark's Clinical Medicine (10th ed.). Elsevier. p. 519. ISBN 978-0-7020-7870-5. Archived from the original on 30 April 2022. Retrieved 29 April 2022.
  5. ↑ Pokorski 2015, p. 28.
  6. 1 2 3 4 5 6 7 8 9 10 11 12 "Rhinitis Versus Sinusitis in Children" (PDF). Centers for Disease Control and Prevention. Archived (PDF) from the original on 16 February 2017. Retrieved 19 December 2016. Public Domain This article incorporates text from this source, which is in the public domain.
  7. ↑ Heymann 2015, pp. 443–445.
  8. 1 2 Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. (December 2012). "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010". Lancet. 380 (9859): 2095–128. doi:10.1016/S0140-6736(12)61728-0. hdl:10536/DRO/DU:30050819. PMID 23245604. Archived from the original on 19 May 2020. Retrieved 3 June 2020.
  9. 1 2 Burket's oral medicine. Glick, Michael (12th ed.). Shelton, Connecticut. ISBN 978-1-60795-280-0. OCLC 903962852.{{cite book}}: CS1 maint: others (link)
  10. ↑ Pokorski 2015, p. 27.
  11. ↑ Bisno AL (January 2001). "Acute pharyngitis". The New England Journal of Medicine. 344 (3): 205–11. doi:10.1056/nejm200101183440308. PMID 11172144.
  12. ↑ "Human papillomavirus (HPV) and Oropharyngeal Cancer, Sexually Transmitted Diseases". Centers for Disease Control and Prevention. 4 November 2016. Archived from the original on 16 December 2016. Retrieved 19 December 2016.
  13. ↑ Hao Q, Dong BR, Wu T (February 2015). Dong BR (ed.). "Probiotics for preventing acute upper respiratory tract infections". The Cochrane Database of Systematic Reviews. 9 (2): CD006895. doi:10.1002/14651858.CD006895.pub3. PMID 25927096.
  14. ↑ "Common Cold: Treatments and Drugs". Mayo Clinic. Archived from the original on 12 February 2010. Retrieved 9 January 2010.
  15. ↑ Weidner T, Schurr T (August 2003). "Effect of exercise on upper respiratory tract infection in sedentary subjects". British Journal of Sports Medicine. 37 (4): 304–6. doi:10.1136/bjsm.37.4.304. PMC 1724675. PMID 12893713.
  16. ↑ Guppy MP, Mickan SM, Del Mar CB (February 2004). ""Drink plenty of fluids": a systematic review of evidence for this recommendation in acute respiratory infections". BMJ. 328 (7438): 499–500. doi:10.1136/bmj.38028.627593.BE. PMC 351843. PMID 14988184.
  17. 1 2 3 4 Reveiz L, Cardona AF (May 2015). "Antibiotics for acute laryngitis in adults". The Cochrane Database of Systematic Reviews (5): CD004783. doi:10.1002/14651858.CD004783.pub5. PMC 6486127. PMID 26002823.
  18. ↑ Tonkin-Crine, Sarah KG; Tan, Pui San; van Hecke, Oliver; Wang, Kay; Roberts, Nia W; McCullough, Amanda; Hansen, Malene Plejdrup; Butler, Christopher C; Del Mar, Chris B (7 September 2017). "Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews". Cochrane Database of Systematic Reviews. 9: CD012252. doi:10.1002/14651858.CD012252.pub2. PMC 6483738. PMID 28881002.
  19. ↑ Gerber JS, Ross RK, Bryan M, Localio AR, Szymczak JE, Wasserman R, Barkman D, Odeniyi F, Conaboy K, Bell L, Zaoutis TE, Fiks AG (December 2017). "Association of Broad- vs Narrow-Spectrum Antibiotics With Treatment Failure, Adverse Events, and Quality of Life in Children With Acute Respiratory Tract Infections". JAMA. 318 (23): 2325–2336. doi:10.1001/jama.2017.18715. PMC 5820700. PMID 29260224.
  20. ↑ Spurling GK, Del Mar CB, Dooley L, Foxlee R, Farley R (September 2017). "Delayed antibiotic prescriptions for respiratory infections". The Cochrane Database of Systematic Reviews. 9: CD004417. doi:10.1002/14651858.CD004417.pub5. PMC 6372405. PMID 28881007.
  21. ↑ Smith SM, Schroeder K, Fahey T (November 2014). "Over-the-counter (OTC) medications for acute cough in children and adults in community settings". The Cochrane Database of Systematic Reviews (11): CD001831. doi:10.1002/14651858.CD001831.pub5. PMC 7061814. PMID 25420096.
  22. ↑ Research, Center for Drug Evaluation and. "Special Features – Use Caution When Giving Cough and Cold Products to Kids". www.fda.gov. Archived from the original on 12 January 2017. Retrieved 23 January 2017.
  23. ↑ Goldsobel AB, Chipps BE (March 2010). "Cough in the pediatric population". The Journal of Pediatrics. 156 (3): 352–8. doi:10.1016/j.jpeds.2009.12.004. PMID 20176183.
  24. ↑ Spurling GK, Del Mar CB, Dooley L, Foxlee R, Farley R (September 2017). Spurling GK (ed.). "Delayed antibiotic prescriptions for respiratory infections". The Cochrane Database of Systematic Reviews. 9: CD004417. doi:10.1002/14651858.CD004417.pub5. PMC 6372405. PMID 28881007.
  25. ↑ Tietze, KJ (2004). "Disorders related to cold and allergy". In Berardi, Rosemary R. (ed.). Handbook of Nonprescription Drugs (14th ed.). Washington, DC: American Pharmacists Association. pp. 239–269. ISBN 978-1-58212-050-8. OCLC 56446842.
  26. ↑ Covington, Timothy R., ed. (2002). "Common cold". Nonprescription Drug Therapy: Guiding Patient Self-care (1st ed.). St Louis, MO: Facts & Comparisons. pp. 743–769. ISBN 978-1-57439-146-6. OCLC 52895543.
  27. 1 2 Chalumeau, Martin; Duijvestijn, Yvonne CM (31 May 2013). "Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease". Cochrane Database of Systematic Reviews (5): CD003124. doi:10.1002/14651858.CD003124.pub4. PMID 23728642.
  28. 1 2 3 Hemilä H, Chalker E (January 2013). "Vitamin C for preventing and treating the common cold". The Cochrane Database of Systematic Reviews (1): CD000980. doi:10.1002/14651858.CD000980.pub4. PMC 1160577. PMID 23440782.
  29. ↑ King D, Mitchell B, Williams CP, Spurling GK (April 2015). "Saline nasal irrigation for acute upper respiratory tract infections" (PDF). The Cochrane Database of Systematic Reviews (4): CD006821. doi:10.1002/14651858.CD006821.pub3. PMID 25892369. Archived (PDF) from the original on 29 August 2021. Retrieved 4 November 2018.
  30. ↑ Global Burden of Disease Study 2013 Collaborators (August 2015). "Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 386 (9995): 743–800. doi:10.1016/s0140-6736(15)60692-4. PMC 4561509. PMID 26063472.
  31. ↑ "Mortality and Burden of Disease Estimates for WHO Member States in 2002" (xls). World Health Organization. 2002. Archived from the original on 16 January 2013.
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