How to Kill Albert Wesker in Resident Evil 5

Wesker may seem intimidating and pretty tough to defeat (especially on higher difficulty settings), but following these simple tips should help you survive and prosper.

Method 1
Method 1 of 4:

Preparing for the fight

First, you must have proper equipment to succeed in defeating him for all three encounters. The recommendations are listed below.

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    What weapon's the best? Magnums and shotguns over sub-machine guns and pistols is the way to go.
    • For Wesker, a rocket launcher is the best (and expensive) way to end fights.
    • For knocking out Jill, a grenade launcher with flash grenades is the best option.
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    First aid/herbs. You should have at least 3 first aid/herbs for each partner.
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Method 2
Method 2 of 4:

First encounter

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    You must flee the area. As of right now, Wesker has the advantage of Jill providing gun fire for him. To negate this effect, run to the right side of your starting position and head for the blue door.
    • Stay behind the column by the door to avoid Jill's gunshots.
    • If playing co-op, one partner should shoot Wesker to draw attention away.
    • The partner in cover should shoot Jill with the flash rounds in the grenade launcher.
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    A cutscene should play. When it ends, Chris should turn around and head up the stairs and into a hallway.
    • As Chris, take cover at the end of the hallway and wait until Wesker comes. Then, shoot him quickly as many times as possible.
    • As Sheva, wait for the above situation to unfold by hiding behind a column. Then when Chris starts shooting Wesker, head up into the hallway he's in and then shoot Wesker from behind while he fights Chris.
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    At this point, he either dashes toward you or he's dazed.
    • If he dashes then run away and repeat step 2.
    • If he is stunned then run up to him and complete the quick time event.
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    Repeat the above.
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    You could also buy the rocket launcher. Shooting him while he holds the rocket instantly ends the fight. Make sure he fights the person not holding the rocket launcher so it's easier that way.
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Method 3
Method 3 of 4:

2nd encounter

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    Run to each spotlight in the area. Then, turn them off. They're in the corner of the map.
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    When all lights are off, run away from Wesker. A cutscene should play.
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    Take out a rocket launcher, and shoot him while he doesn't notice you. Shoot the rocket and the fight is over.
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Method 4
Method 4 of 4:

3rd encounter

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    At the start, turn around and run towards the bridge. A cutscene should play. After that, your roles will be different.
    • As Chris, get to the center of the map and get Wesker to start trying to hit you.
    • As Sheva, while Wesker tries to hit Chris, pull out a rocket launcher and shoot his orange spot on the back. Fight over.

Warnings

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Things You'll Need

  • Any weapon.
  • First Aid Spray/Herb.

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About This Article

wikiHow is a “wiki,” similar to Wikipedia, which means that many of our articles are co-written by multiple authors. To create this article, 10 people, some anonymous, worked to edit and improve it over time. This article has been viewed 80,212 times.
21 votes - 35%
Co-authors: 10
Updated: July 2, 2020
Views: 80,212
Categories: Resident Evil
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