2,4-Dichlorobenzyl alcohol

2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections. It is a common ingredient in throat lozenges such as Cofsils, Strepsils, Lorsept, and Gorpils. It is also an ingredient in the European product Neo Borocillina.[1] A low-pH throat lozenge containing dichlorobenzyl alcohol (1.2 mg) and amylmetacresol (0.6 mg) has been found to deactivate respiratory syncytial virus and SARS-Cov, but not adenovirus or rhinovirus.[2] A dentifrice containing 10% sodium benzoate and 0.3% dichlorobenzyl alcohol maintains antimicrobial activity for 5 to 10 minutes after brushing.[3]

2,4-Dichlorobenzyl alcohol
Names
Preferred IUPAC name
(2,4-Dichlorophenyl)methanol
Other names
Dybenal
Rapidosept
Myacide SP
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.015.646
UNII
  • InChI=1S/C7H6Cl2O/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2 checkY
    Key: DBHODFSFBXJZNY-UHFFFAOYSA-N checkY
  • InChI=1/C7H6Cl2O/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2
    Key: DBHODFSFBXJZNY-UHFFFAOYAI
  • C1=CC(=C(C=C1Cl)Cl)CO
  • Clc1cc(Cl)ccc1CO
Properties
C7H6Cl2O
Molar mass 177.02 g·mol−1
Melting point 57 to 60 °C (135 to 140 °F; 330 to 333 K)
Boiling point 150 °C (302 °F; 423 K) 25 mmHg
Pharmacology
R02AA03 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

References
  1. "Neo Borocillina". drugs.com. Archived from the original on 2020-09-13. Retrieved 2018-01-23.
  2. Oxford JS, Lambkin R, Gibb I, Balasingam S, Chan C, Catchpole A (2005). "A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV". Antiviral Chemistry & Chemotherapy. 16 (2): 129–34. doi:10.1177/095632020501600205. PMID 15889535.
  3. Ostergaard E (1994). "Evaluation of the antimicrobial effects of sodium benzoate and dichlorobenzyl alcohol against dental plaque microorganisms. An in vitro study". Acta Odontol Scand. 52 (6): 335–45. doi:10.3109/00016359409029031. PMID 7887143.
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