CRTC3

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene.[5][6][7]

CRTC3
Identifiers
AliasesCRTC3, TORC-3, TORC3, CREB regulated transcription coactivator 3
External IDsOMIM: 608986 MGI: 1917711 HomoloGene: 11248 GeneCards: CRTC3
Orthologs
SpeciesHumanMouse
Entrez

64784

70461

Ensembl

ENSG00000140577

ENSMUSG00000030527

UniProt

Q6UUV7

Q91X84

RefSeq (mRNA)

NM_001042574
NM_022769

NM_173863

RefSeq (protein)

NP_001036039
NP_073606

NP_776288

Location (UCSC)Chr 15: 90.53 – 90.65 MbChr 7: 80.24 – 80.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene has been shown to be linked to weight gain.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000140577 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030527 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
  6. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
  7. "Entrez Gene: CRTC3 CREB regulated transcription coactivator 3".
  8. Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR, Chen YD, Taylor KD, Hsueh WA, Rotter JI, Montminy M (Dec 2010). "CRTC3 links catecholamine signalling to energy balance". Nature. 468 (7326): 933–939. Bibcode:2010Natur.468..933S. doi:10.1038/nature09564. PMC 3025711. PMID 21164481.

Further reading


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