PNRC1

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.[5][6]

PNRC1
Identifiers
AliasesPNRC1, B4-2, PNAS-145, PROL2, PRR2, proline rich nuclear receptor coactivator 1
External IDsOMIM: 606714 MGI: 1917838 HomoloGene: 4960 GeneCards: PNRC1
Orthologs
SpeciesHumanMouse
Entrez

10957

108767

Ensembl

ENSG00000146278

ENSMUSG00000040128

UniProt

Q12796
Q49A59

Q3TWH3

RefSeq (mRNA)

NM_006813

NM_001033225

RefSeq (protein)

NP_006804

NP_001028397

Location (UCSC)Chr 6: 89.08 – 89.09 MbChr 4: 33.25 – 33.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR.[7][8] The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000146278 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040128 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen J, Liu L, Pohajdak B (Dec 1995). "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content". Biochim Biophys Acta. 1264 (1): 19–22. doi:10.1016/0167-4781(95)00159-e. PMID 7578250.
  6. "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1".
  7. Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S (July 2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. doi:10.1210/mend.14.7.0480. PMID 10894149.
  8. Zhou D, Chen S (October 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. doi:10.1093/nar/29.19.3939. PMC 60244. PMID 11574675.

Further reading


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