Gem-associated protein 5

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.[5][6]

GEMIN5
Identifiers
AliasesGEMIN5, GEMIN-5, gem nuclear organelle associated protein 5, NEDCAM
External IDsOMIM: 607005 MGI: 2449311 HomoloGene: 9155 GeneCards: GEMIN5
Orthologs
SpeciesHumanMouse
Entrez

25929

216766

Ensembl

ENSG00000082516

ENSMUSG00000037275

UniProt

Q8TEQ6

Q8BX17

RefSeq (mRNA)

NM_015465
NM_001252156

NM_001166669
NM_001166670
NM_001166671
NM_172558
NM_001374702

RefSeq (protein)

NP_001239085
NP_056280

NP_001160141
NP_001160142
NP_001160143
NP_766146
NP_001361631

Location (UCSC)Chr 5: 154.89 – 154.94 MbChr 11: 58.01 – 58.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Gem-associated protein 5 is part of the SMN a large protein complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), gem-associated protein 2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).[6]

Interactions

GEMIN5 has been shown to interact with DDX20[5][7] and SMN1.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000082516 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037275 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (Feb 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J Biol Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
  6. "Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5".
  7. Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.

Further reading


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