List of therapeutic monoclonal antibodies
Therapeutic, diagnostic and preventive monoclonal antibodies are clones of a single parent cell. When used as drugs, the International Nonproprietary Names (INNs) end in -mab. The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies.
![](../I/Engineered_monoclonal_antibodies.svg.png.webp)
Types of monoclonal antibodies with other structures than naturally occurring antibodies.
The abbreviations in the column Type are as follows:
- mab: whole monoclonal antibody
- Fab: fragment, antigen-binding (one arm)
- F(ab')2: fragment, antigen-binding, including hinge region (both arms)
- Fab': fragment, antigen-binding, including hinge region (one arm)
- Variable fragments:
- scFv: single-chain variable fragment
- di-scFv: dimeric single-chain variable fragment
- sdAb: single-domain antibody
- BsAb: bispecific monoclonal antibody:
- 3funct: trifunctional antibody
- BiTE: bi-specific T-cell engager
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
Name | Brand name | Type | Source | Target | Approved | Use |
---|---|---|---|---|---|---|
3F8 | mab | mouse | GD2 ganglioside | neuroblastoma | ||
Abagovomab[1] | mab | mouse | CA-125 (imitation) | ovarian cancer | ||
Abciximab[2] | ReoPro | Fab | chimeric | CD41 (integrin alpha-IIb) | Y[3] | platelet aggregation inhibitor |
Abituzumab[4] | mab | humanized | CD51 | cancer | ||
Abrezekimab[5] | Fab | humanized | IL-13 | |||
Abrilumab[6] | mab | human | integrin α4 β7 | inflammatory bowel disease, ulcerative colitis, Crohn's disease | ||
Actoxumab[6] | mab | human | Clostridium difficile | Clostridium difficile colitis | ||
Adalimumab[7] | Humira | mab | human | TNF-α | Y[8] | rheumatoid arthritis, Crohn's disease, plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, hemolytic disease of the newborn |
Adecatumumab[9] | mab | human | EpCAM | prostate and breast cancer | ||
Aducanumab[10] | Aduhelm | mab | human | Amyloid beta | Y[11] | Alzheimer's disease |
Afasevikumab[12] | mab | human | IL-17A, IL-17F | multiple sclerosis | ||
Afelimomab[2] | F(ab')2 | mouse | TNF-α | sepsis | ||
Alacizumab pegol[13] | F(ab')2 | humanized | VEGFR2 | cancer | ||
Alemtuzumab[14] | Lemtrada, Campath | mab | humanized | CD52 | Y | multiple sclerosis |
Alirocumab[15] | Praluent | mab | human | PCSK9 | Y | hypercholesterolemia |
Altumomab pentetate | Hybri-ceaker | mab | mouse | Carcinoembryonic antigen (CEA) | colorectal cancer (diagnosis) | |
Amatuximab[16] | mab | chimeric | mesothelin | cancer | ||
Amivantamab | Rybrevant | BsAb | human | Epidermal growth factor receptor (EGFR), cMet | Y | non-small cell lung cancer |
Anatumomab mafenatox[17] | Fab | mouse | Tumor-associated glycoprotein 72 (TAG-72) | non-small cell lung cancer | ||
Andecaliximab[18] | mab | chimeric | gelatinase B | gastric cancer or gastroesophageal junction adenocarcinoma | ||
Anetumab ravtansine[4] | mab | human | mesothelin (MSLN) | cancer | ||
Anifrolumab[4] | Saphnelo | mab | human | IFN-α/β receptor | Y[19] | systemic lupus erythematosus |
Ansuvimab | Ebanga | mab | human | Ebola virus glycoprotein | Y | treatment of Zaire ebolavirus (Ebola virus) |
Anrukinzumab[13] (= IMA-638)[20] | mab | humanized | IL-13 | asthma | ||
Apolizumab[21] | mab | humanized | HLA-DR | hematological cancers | ||
Aprutumab ixadotin[22] | mab | human | FGFR2 | |||
Arcitumomab[23] | CEA-Scan | Fab' | mouse | Carcinoembryonic antigen (CEA) | gastrointestinal cancers (diagnosis) | |
Ascrinvacumab[12] | mab | human | activin receptor-like kinase 1 | cancer | ||
Aselizumab[24] | mab | humanized | L-selectin (CD62L) | severely injured patients | ||
Atezolizumab[25] | Tecentriq | mab | humanized | PD-L1 | Y | cancer |
Atidortoxumab[26] | mab | human | Staphylococcus aureus alpha toxin | |||
Atinumab[16] | mab | human | RTN4 | |||
Atoltivimab | mab | human | part of Atoltivimab/maftivimab/odesivimab for treatment of Zaire ebolavirus (Ebola virus) | |||
Atoltivimab/maftivimab/odesivimab | Inmazeb | mab | human | Y | treatment of Zaire ebolavirus (Ebola virus) | |
Atorolimumab[2] | mab | human | Rhesus factor | hemolytic disease of the newborn | ||
Avelumab[12] | Bavencio | mab | human | PD-L1 | Y | cancer |
Azintuxizumab vedotin[27] | mab | chimeric/ humanized | CD319 | cancer | ||
Bamlanivimab[28] | mab | human | spike protein receptor binding domain (RBD) of SARS-CoV-2 | Emergency Use Authorization (EUA) when used with etesevimab[29] | COVID-19 | |
Bapineuzumab[30] | mab | humanized | β-amyloid | Alzheimer's disease | ||
Basiliximab[31] | Simulect | mab | chimeric | CD25 (α chain of IL-2 receptor) | Y | prevention of organ transplant rejections |
Bavituximab[1] | mab | chimeric | phosphatidylserine | cancer, viral infections | ||
BCD-100 | human | PD-1 | melanoma | |||
Bebtelovimab[32] | mab | human | spike protein receptor binding domain (RBD) of SARS-CoV-2 | Emergency Use Authorization (EUA)[33] | COVID-19 | |
Bectumomab[31] | LymphoScan | Fab' | mouse | CD22 | non-Hodgkin's lymphoma (detection) | |
Bedinvetmab[34] | Librela[35] | mab | veterinary | nerve growth factor (NGF)[35] | Y | pain associated with osteoarthritis in dogs[35] |
Begelomab[6] | mab | mouse | DPP4 | |||
Belantamab mafodotin[5] | Blenrep | mab | humanized | B-cell maturation antigen (BCMA) | Y | relapsed or refractory multiple myeloma |
Belimumab[36] | Benlysta | mab | human | B-cell activating factor (BAFF) | Y | systemic lupus erythematosus without renal or CNS involvement |
Bemarituzumab[26] | mab | humanized | FGFR2 | gastric cancer or gastroesophageal junction adenocarcinoma | ||
Benralizumab[37] | Fasenra | mab | humanized | CD125 | Y | asthma |
Berlimatoxumab[26] | mab | human | Staphylococcus aureus bi-component leukocidin | |||
Bermekimab[31] | Xilonix | mab | human | IL-1α | colorectal cancer | |
Bersanlimab[5] | mab | human | ICAM-1 | |||
Bertilimumab[24] | mab | human | CCL11 (eotaxin-1) | severe allergic disorders | ||
Besilesomab[38] | Scintimun | mab | mouse | Carcinoembryonic antigen (CEA)-related antigen | inflammatory lesions and metastases (detection) | |
Bevacizumab[14] | Avastin | mab | humanized | VEGF-A | Y | metastatic cancer, retinopathy of prematurity |
Bezlotoxumab[31] | Zinplava | mab | human | Clostridium difficile | Y | Clostridium difficile colitis |
Biciromab[31] | FibriScint | Fab' | mouse | fibrin II, beta chain | thromboembolism (diagnosis) | |
Bimagrumab[39] | mab | human | ACVR2B | myostatin inhibitor | ||
Bimekizumab[10] | Bimzelx | mab | humanized | IL-17A, IL-17F, IL-17AF | Y | psoriasis |
Birtamimab | mab | chimeric | serum amyloid A protein | amyloidosis | ||
Bivatuzumab[31] | mab | humanized | CD44 v6 | squamous cell carcinoma | ||
Bleselumab[12] | mab | human | CD40 | organ transplant rejection | ||
Blinatumomab[31] | Blincyto | BiTE | mouse | CD19 | Y | pre-B Acute lymphoblastic leukemia (ALL) (CD19+) |
Blontuvetmab[40] | Blontress | mab | veterinary | CD20 | ||
Blosozumab[41] | mab | humanized | SOST | osteoporosis | ||
Bococizumab[31] | mab | humanized | PCSK9 | dyslipidemia | ||
Brazikumab[18] | mab | human | IL-23 | Crohn's disease | ||
Brentuximab vedotin[31] | Adcentris | mab | chimeric | CD30 (TNFRSF8) | Y | Hodgkin's lymphoma, anaplastic large-cell lymphoma |
Briakinumab[31] | mab | human | IL-12, IL-23 | psoriasis, rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis | ||
Brodalumab[41] | Siliq | mab | human | IL-17 | Y | Plaque psoriasis |
Brolucizumab[25] | Beovu | scFv | humanized | vascular endothelial growth factor A (VEGFA) | Y | wet age-related macular degeneration |
Brontictuzumab[6] | mab | humanized | Notch 1 | cancer | ||
Burosumab[18] | Crysvita | mab | human | FGF 23 | Y | X-linked hypophosphatemia |
Cabiralizumab[40] | mab | humanized | CSF1R | metastatic pancreatic cancer | ||
Camidanlumab tesirine[26] | mab | human | CD25 (α chain of IL-2 receptor) | B-cell Hodgkin's lymphoma, non-Hodgkin lymphoma, acute lymphoblastic leukemia, acute myeloid leukemia | ||
Camrelizumab[22] | mab | humanized | PD-1 | hepatocellular carcinoma | ||
Canakinumab[42] | Ilaris | mab | human | IL-1 | Y | cryopyrin-associated periodic syndrome |
Cantuzumab mertansine[41] | mab | humanized | CanAg (a glycoform of MUC1) | colorectal cancer etc. | ||
Cantuzumab ravtansine[41] | mab | humanized | CanAg (a glycoform of MUC1) | cancers | ||
Caplacizumab[43] | Cablivi | sdAb | humanized | VWF | Y | thrombotic thrombocytopenic purpura, thrombosis |
Casirivimab[28] | mab | human | spike protein receptor binding domain (RBD) of SARS-CoV-2 | Yes when used with imdevimab[44][45] | COVID-19 | |
Capromab[31] | Prostascint | mab | mouse | Glutamate carboxypeptidase II | Y | prostate cancer (detection) |
Carlumab[16] | mab | human | MCP-1 | oncology/immune indications | ||
Carotuximab[40] | mab | chimeric | endoglin | angiosarcoma | ||
Catumaxomab[30] | Removab | 3funct | rat/mouse hybrid | EpCAM, CD3 | Y | ovarian cancer, malignant ascites, gastric cancer |
cBR96-doxorubicin immunoconjugate | mab | humanized | Lewis-Y antigen | cancer | ||
Cedelizumab[46] | mab | humanized | CD4 | prevention of organ transplant rejections, treatment of autoimmune diseases | ||
Cemiplimab[31] | Libtayo | mab | human | PD-1 | Y | cutaneous squamous cell carcinoma |
Cergutuzumab amunaleukin[12] | mab | humanized | IL-2 | cancer | ||
Certolizumab pegol[42] | Cimzia | Fab' | humanized | TNF-α | Y | Crohn's disease, rheumatoid arthritis, axial spondyloarthritis, psoriasis arthritis |
Cetrelimab[5] | mab | human | PD-1 | cancer | ||
Cetuximab[31] | Erbitux | mab | chimeric | Epidermal growth factor receptor (EGFR) | Y | metastatic colorectal cancer and head and neck cancer |
Cibisatamab[5] | mab | humanized | CEACAM5 | cancer | ||
Cilgavimab[28] | mab | human | spike protein receptor binding domain (RBD) of SARS-CoV-2 | Emergency Use Authorization (EUA) when used with tixagevimab[47] | COVID-19 | |
Cirmtuzumab[31] | humanized | ROR1 | chronic lymphocytic leukemia | |||
Citatuzumab bogatox[48] | Fab | humanized | EpCAM | ovarian cancer and other solid tumors | ||
Cixutumumab[31] | mab | human | IGF-1 receptor (CD221) | solid tumors | ||
Clazakizumab[49] | mab | humanized | IL-6 | rheumatoid arthritis | ||
Clenoliximab[31] | mab | chimeric | CD4 | rheumatoid arthritis | ||
Clivatuzumab tetraxetan[31] | hPAM4-Cide | mab | humanized | MUC1 | pancreatic cancer | |
Codrituzumab[4] | mab | humanized | glypican 3 | cancer | ||
Cofetuzumab pelidotin[26] | mab | humanized | PTK7 | cancer | ||
Coltuximab ravtansine[4] | mab | chimeric | CD19 | cancer | ||
Conatumumab[48] | mab | human | TRAIL-R2 | cancer | ||
Concizumab[50] | Alhemo | mab | humanized | tissue factor pathway inhibitor (TFPI) | Y | bleeding with hemophilia |
Cosfroviximab[27] | ZMapp | mab | chimeric | ebolavirus glycoprotein | Ebola virus | |
Crenezumab[31] | mab | humanized | β-amyloid (1-40 and 1-42) | Alzheimer's disease | ||
Crizanlizumab[22] | Adakveo | mab | humanized | selectin P | Y | sickle-cell disease |
Crotedumab[40] | mab | human | glucagon receptor (GCGR) | diabetes | ||
CR6261 | mab | human | Hemagglutinin (influenza) | infectious disease/influenza A | ||
Cusatuzumab[5] | mab | humanized | CD70 | cancer | ||
Dacetuzumab[13] | mab | humanized | CD40 | hematologic cancers | ||
Daclizumab[51] | Zenapax | mab | humanized | CD25 (α chain of IL-2 receptor) | Y | prevention of organ transplant rejections, multiple sclerosis |
Dalotuzumab | mab | humanized | IGF-1 receptor (CD221) | cancer etc. | ||
Dapirolizumab pegol[52] | mab | humanized | CD154 (CD40L) | |||
Daratumumab[53] | Darzalex | mab | human | CD38 | Y[54] | multiple myeloma |
Dectrekumab[25] | mab | human | IL-13 | |||
Demcizumab | mab | humanized | DLL4 | cancer | ||
Denintuzumab mafodotin[6] | mab | humanized | CD19 | cancer | ||
Denosumab[55] | Prolia | mab | human | RANKL | Y | osteoporosis, bone metastases etc. |
Depatuxizumab mafodotin[22] | mab | chimeric/ humanized | EGFR | glioblastoma | ||
Derlotuximab biotin | mab | chimeric | histone complex | recurrent glioblastoma multiforme | ||
Detumomab | mab | mouse | B-lymphoma cell | lymphoma | ||
Dezamizumab[22] | mab | humanized | serum amyloid P component | |||
Dinutuximab | Unituxin | mab | chimeric | GD2 ganglioside | Y | neuroblastoma |
Dinutuximab beta | Qarziba | mab | chimeric | GD2 ganglioside | Y | neuroblastoma |
Diridavumab | mab | human | Hemagglutinin (influenza) | influenza A | ||
Domagrozumab[40] | mab | humanized | GDF-8 | Duchenne muscular dystrophy | ||
Donanemab | mab | humanized | Amyloid beta | Alzheimer's disease | ||
Dorlimomab aritox[56] | F(ab')2 | mouse | ||||
Dostarlimab[57] | Jemperli | mab | humanized | PCDP1 | Y | endometrial cancer |
Drozitumab | mab | human | DR5 | cancer etc. | ||
DS-8201 | humanized | HER2 | gastric or gastroesophageal junction adenocarcinoma | |||
Duligotuzumab[15] | mab | humanized | ERBB3 (HER3) | testicular cancer | ||
Dupilumab[39] | Dupixent | mab | human | IL-4Rα | Y | atopic dermatitis, asthma, nasal polyps |
Durvalumab[25] | Imfinzi | mab | human | PD-L1 | Y | cancer |
Dusigitumab | mab | human | IGF-2 | B-cell malignancies | ||
Duvortuxizumab[27] | scFv | chimeric/ humanized | CD19, CD3E | cancer | ||
Ecromeximab[21] | mab | chimeric | GD3 ganglioside | malignant melanoma | ||
Eculizumab[21] | Soliris | mab | humanized | C5 | Y | paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome |
Edobacomab | mab | mouse | endotoxin | sepsis caused by Gram-negative bacteria | ||
Edrecolomab | Panorex | mab | mouse | EpCAM | colorectal carcinoma | |
Efalizumab[7] | Raptiva | mab | humanized | LFA-1 (CD11a) | psoriasis (blocks T-cell migration) | |
Efungumab[1] | Mycograb | scFv | human | Hsp90 | invasive Candida infection | |
Eldelumab[4] | mab | human | CXCL10 (IP-10) | Crohn's disease, ulcerative colitis | ||
Elezanumab[22] | mab | human | repulsive guidance molecule A (RGMA) | spinal cord injury and multiple sclerosis | ||
Elgemtumab[25] | mab | human | ERBB3 (HER3) | cancer | ||
Elotuzumab | Empliciti | mab | humanized | SLAMF7 | Y | multiple myeloma |
Elsilimomab | mab | mouse | IL-6 | |||
Emactuzumab[6] | mab | humanized | CSF1R | cancer | ||
Emapalumab[22] | Gamifant | mab | human | IFN-γ | Y | hemophagocytic lymphohistiocytosis |
Emibetuzumab | mab | humanized | HGFR | cancer | ||
Emicizumab[12] | Hemlibra | BsAb | humanized | activated F9, F10 | Y | haemophilia A |
Enapotamab vedotin[5] | mab | human | AXL | cancer | ||
Enavatuzumab | mab | humanized | TWEAK receptor | cancer etc. | ||
Enfortumab vedotin[4] | Padcev | mab | human | nectin-4 | Y[58] | urothelial cancer |
Enlimomab pegol[59] | mab | mouse | ICAM-1 (CD54) | |||
Enoblituzumab[22] | mab | humanized | CD276 | cancer | ||
Enokizumab | mab | humanized | IL-9 | asthma | ||
Enoticumab[15] | mab | human | DLL4 | |||
Ensituximab | mab | chimeric | MUC5AC | cancer | ||
Epcoritamab | Epkinly[60][61] | BiTE | humanized | CD3, CD20 | Y | diffuse large B-cell lymphoma |
Epitumomab cituxetan[62] | mab | mouse | episialin | |||
Epratuzumab | mab | humanized | CD22 | cancer, systemic lupus erythematosus (SLE) | ||
Eptinezumab[22] | Vyepti | mab | humanized | calcitonin gene-related peptide | Y[63] | migraine |
Erenumab[22] | Aimovig | mab | human | calcitonin gene-related peptide receptor (CGRP) | Y | migraine |
Erlizumab[64] | F(ab')2 | humanized | ITGB2 (CD18) | heart attack, stroke, traumatic shock | ||
Ertumaxomab[30] | Rexomun | 3funct | rat/mouse hybrid | HER2/neu, CD3 | Y | breast cancer etc. |
Etaracizumab | Abegrin | mab | humanized | integrin αvβ3 | Y | melanoma, prostate cancer, ovarian cancer etc. |
Etesevimab[28] | mab | human | spike protein receptor binding domain (RBD) of SARS-CoV-2 | Emergency Use Authorization (EUA) when used with bamlanivimab[29] | COVID-19 | |
Etigilimab[5] | mab | humanized | TIGIT | |||
Etrolizumab[16] | mab | humanized | integrin β7 | inflammatory bowel disease | ||
Evinacumab | Evkeeza | mab | human | angiopoietin 3 | Y | dyslipidemia |
Evolocumab[39] | Repatha | mab | human | PCSK9 | Y | hypercholesterolemia |
Exbivirumab[65] | mab | human | hepatitis B surface antigen | hepatitis B | ||
Fanolesomab[17] | NeutroSpec | mab | mouse | CD15 | appendicitis (diagnosis) | |
Faralimomab | mab | mouse | IFN receptor | |||
Faricimab[66] | Vabysmo | mab | humanized | VEGF-A and Ang-2 | Y | angiogenesis, ocular vascular diseases |
Farletuzumab | mab | humanized | folate receptor 1 | ovarian cancer | ||
Fasinumab | mab | human | nerve growth factor (NGF) | acute sciatic pain | ||
FBTA05[67][68] | Lymphomun | 3funct | rat/mouse hybrid | CD20 | chronic lymphocytic leukaemia | |
Felvizumab | mab | humanized | respiratory syncytial virus | respiratory syncytial virus infection | ||
Fezakinumab[69][70] | mab | human | IL-22 | rheumatoid arthritis, psoriasis | ||
Fibatuzumab[71] | mab | humanized | ephrin receptor A3 | |||
Ficlatuzumab | mab | humanized | Hepatocyte growth factor (HGF) | cancer etc. | ||
Figitumumab | mab | human | IGF-1 receptor (CD221) | adrenocortical carcinoma, non-small cell lung carcinoma etc. | ||
Firivumab[6] | mab | human | Hemagglutinin (influenza) | |||
Flanvotumab | mab | human | TYRP1 (glycoprotein 75) | melanoma | ||
Fletikumab | mab | human | IL-20 | rheumatoid arthritis | ||
Flotetuzumab[5] | di-scFv | humanized | IL-3 receptor | hematological malignancies | ||
Fontolizumab[21] | HuZAF | mab | humanized | IFN-γ | Crohn's disease etc. | |
Foralumab[72] | mab | human | CD3E | |||
Foravirumab[48] | mab | human | rabies virus glycoprotein | rabies (prophylaxis) | ||
Fremanezumab[22] | Ajovy | mab | humanized | calcitonin gene-related peptide alpha and beta | Y | migraine |
Fresolimumab[53] | mab | human | TGF-β | idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, cancer | ||
Frovocimab[57] | mab | humanized | PCSK9 | hypercholesterolemia | ||
Frunevetmab[73] | Solensia[74] | mab | veterinary | nerve growth factor (NGF)[74] | Y | pain associated with osteoarthritis in cats[74] |
Fulranumab | mab | human | nerve growth factor (NGF) | pain | ||
Futuximab[15] | mab | chimeric | Epidermal growth factor receptor (EGFR) | cancer | ||
Galcanezumab[40] | Emgality | mab | humanized | calcitonin | Y | migraine |
Galiximab | mab | chimeric | CD80 | B-cell lymphoma | ||
Gancotamab | scFv | human | HER2/neu | cancer | ||
Ganitumab | mab | human | IGF-1 receptor (CD221) | cancer | ||
Gantenerumab[42] | mab | human | β-amyloid (1-40 and 1-42) | Alzheimer's disease | ||
Gatipotuzumab[27] | mab | humanized | MUC1 | cancer | ||
Gavilimomab[64] | mab | mouse | CD147 (basigin) | graft versus host disease | ||
Gedivumab[27] | mab | human | Hemagglutinin (influenza) | |||
Gemtuzumab ozogamicin[22] | Mylotarg | mab | humanized | CD33 | Y | acute myelogenous leukemia |
Gevokizumab | mab | humanized | IL-1β | diabetes etc. | ||
Gilvetmab[27] | mab | veterinary | PCDC1 | |||
Gimsilumab[26] | mab | human | CSF2 | rheumatoid arthritis | ||
Girentuximab[53] | Rencarex | mab | chimeric | carbonic anhydrase 9 (CA-IX) | clear cell renal cell carcinoma[75] | |
Glembatumumab vedotin[37][76] | mab | human | GPNMB | melanoma, breast cancer | ||
Glofitamab[60] | Columvi[77] | BsAb | humanized | CD20, CD3 | Y[77] | diffuse large B-cell lymphoma[77] |
Golimumab[65] | Simponi | mab | human | TNF-α | Y | rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis |
Gomiliximab | mab | chimeric | CD23 (IgE receptor) | allergic asthma | ||
Gosuranemab | mab | humanized | tau protein | progressive supranuclear palsy | ||
Guselkumab | Tremfya | mab | human | IL-23 | Y | psoriasis |
Ianalumab[26] | mab | human | BAFF-R | autoimmune hepatitis | ||
Ibalizumab[42] | Trogarzo | mab | humanized | CD4 | Y | HIV infection |
Sintilimab | human | PD-1 | squamous cell non-small cell lung cancer | |||
Ibritumomab tiuxetan | Zevalin | mab | mouse | CD20 | Y | non-Hodgkin's lymphoma |
Icrucumab | mab | human | VEGFR-1 | cancer etc. | ||
Idarucizumab[4] | Praxbind | mab | humanized | dabigatran | Y | reversal of anticoagulant effects of dabigatran |
Ifabotuzumab[22] | mab | humanized | EPHA3 | glioblastoma multiforme[78] | ||
Igovomab | Indimacis-125 | F(ab')2 | mouse | CA-125 | ovarian cancer (diagnosis) | |
Iladatuzumab vedotin[26] | mab | humanized | CD79B | cancer | ||
Imalumab[6] | mab | human | macrophage migration inhibitory factor (MIF) | cancer | ||
Imaprelimab[5] | mab | humanized | melanoma cell adhesion molecule (MCAM) | |||
Imciromab | Myoscint | mab | mouse | cardiac myosin | Y | cardiac imaging |
Imdevimab[28] | mab | human | spike protein receptor binding domain (RBD) of SARS-CoV-2 | Yes when used with casirivimab[44][45] | COVID-19 | |
Imgatuzumab[15] | mab | humanized | Epidermal growth factor receptor (EGFR) | cancer | ||
Inclacumab[43] | mab | human | selectin P | cardiovascular disease | ||
Indatuximab ravtansine[41] | mab | chimeric | SDC1 | cancer | ||
Indusatumab vedotin[25] | mab | human | GUCY2C | cancer | ||
Inebilizumab[12] | Uplizna | mab | humanized | CD19 | Y[79] | cancer, systemic sclerosis, multiple sclerosis |
Infliximab | Remicade | mab | chimeric | TNF-α | Y | rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis, Crohn's disease, ulcerative colitis |
Intetumumab[80][81] | mab | human | CD51 | solid tumors (prostate cancer, melanoma) | ||
Inolimomab | mab | mouse | CD25 (α chain of IL-2 receptor) | graft versus host disease | ||
Inotuzumab ozogamicin[38] | Besponsa | mab | humanized | CD22 | Y | Acute lymphoblastic leukemia (ALL) |
Ipilimumab[55] | Yervoy | mab | human | CD152 | Y | melanoma |
Iomab-B | mouse | CD45 | ablation of bone marrow | |||
Iratumumab[55] | mab | human | CD30 (TNFRSF8) | Hodgkin's lymphoma | ||
Isatuximab | Sarclisa | mab | chimeric | CD38 | Y | multiple myeloma |
Iscalimab[5] | mab | human | CD40 | |||
Istiratumab[26] | mab | human | IGF-1 receptor (CD221) | advanced solid tumors | ||
Itolizumab[72] | Alzumab | mab | humanized | CD6 | Y | psoriasis |
Ixekizumab | Taltz | mab | humanized | IL-17A | Y | autoimmune diseases |
Keliximab | mab | chimeric | CD4 | chronic asthma | ||
Labetuzumab[7] | CEA-Cide | mab | humanized | Carcinoembryonic antigen (CEA) | colorectal cancer | |
Lacnotuzumab[27] | mab | humanized | CSF1, macrophage colony stimulating factor (MCSF) | cancer | ||
Ladiratuzumab vedotin[26] | mab | humanized | LIV-1 | cancer | ||
Lampalizumab[15] | Fab | humanized | Complement factor D (CFD) | geographic atrophy secondary to age-related macular degeneration | ||
Lanadelumab[40] | Takhzyro | mab | human | kallikrein | Y | angioedema |
Landogrozumab[12] | mab | humanized | GDF-8 | muscle wasting disorders | ||
Laprituximab emtansine[40] | mab | chimeric | epidermal growth factor receptor (EGFR) | |||
Larcaviximab[27] | mab | chimeric | ebolavirus glycoprotein | Ebola virus | ||
Lebrikizumab | mab | humanized | IL-13 | asthma | ||
Lecanemab[82] | Leqembi | mab | humanized | β-amyloid | Y[83] | Alzheimer's disease |
Lemalesomab[64] | mab | mouse | NCA-90 (granulocyte antigen) | diagnostic agent | ||
Lendalizumab[40] | mab | humanized | C5 | |||
Lenvervimab[5] | mab | humanized | hepatitis B surfage antigen | hepatitis B | ||
Lenzilumab[6] | mab | human | CSF2 | chronic myelomonocytic leukemia and juvenile myelomonocytic leukemia | ||
Lerdelimumab[17] | mab | human | TGF-β2 | reduction of scarring after glaucoma surgery | ||
Leronlimab[5] | mab | humanized | CCR5 | breast cancer, HIV | ||
Lesofavumab[27] | mab | human | Hemagglutinin (influenza) | |||
Letolizumab[27] | scFv | humanized | tumor necrosis factor related activation protein (TRAP) | inflammatory diseases | ||
Lexatumumab[1] | mab | human | TRAIL-R2 | cancer | ||
Libivirumab[65] | mab | human | hepatitis B surface antigen | hepatitis B | ||
Lifastuzumab vedotin | mab | humanized | phosphate-sodium co-transporter | cancer | ||
Ligelizumab[15] | mab | humanized | IGHE | severe asthma, chronic spontaneous urticaria | ||
Loncastuximab tesirine[84][71] | Zynlonta | mab | chimeric | CD19 | Y | relapsed or refractory large B-cell lymphoma |
Losatuxizumab vedotin[27] | mab | chimeric/ humanized | epidermal growth receptor factor (EGRF), ERBB1 HER1 | cancer | ||
Lilotomab satetraxetan[25] | mab | mouse | CD37 | cancer | ||
Lintuzumab | mab | humanized | CD33 | cancer | ||
Lirilumab[15] | mab | human | KIR2D | solid and hematological cancers | ||
Lodelcizumab[39] | mab | humanized | PCSK9 | hypercholesterolemia | ||
Lokivetmab[25] | Cytopoint[85] | mab | veterinary | Canis lupus familiaris IL31 | Y | clinical signs of atopic dermatitis in dogs[85] |
Lorvotuzumab mertansine | mab | humanized | CD56 | cancer | ||
Lucatumumab[13] | mab | human | CD40 | multiple myeloma, non-Hodgkin's lymphoma, Hodgkin's lymphoma | ||
Lulizumab pegol[6] | mab | humanized | CD28 | autoimmune diseases | ||
Lumiliximab[9] | mab | chimeric | CD23 (IgE receptor) | chronic lymphocytic leukemia | ||
Lumretuzumab[6] | mab | humanized | ERBB3 (HER3) | cancer | ||
Lupartumab[22] | mab | human | ||||
Lupartumab amadotin[22] | mab | human | LYPD3 | |||
Lutikizumab[22] | mab | humanized | IL-1α | |||
Maftivimab | mab | human | part of Atoltivimab/maftivimab/odesivimab for treatment of Zaire ebolavirus (Ebola virus) | |||
Mapatumumab[30] | mab | human | TRAIL-R1 | cancer | ||
Margetuximab | Margenza[86] | mab | humanized | HER2 | Y | breast cancer |
Marstacimab | mab | human | tissue factor pathway inhibitor (TFPI) | bleeding with hemophilia | ||
Maslimomab | mouse | T-cell receptor | ||||
Mavrilimumab[37] | mab | human | GMCSF receptor α-chain | rheumatoid arthritis | ||
Matuzumab[24] | mab | humanized | Epidermal growth factor receptor (EGFR) | colorectal, lung and stomach cancer | ||
Mepolizumab[46] | Bosatria | mab | humanized | IL-5 | Y | asthma and white blood cell diseases |
Metelimumab[24] | mab | human | TGF-β1 | systemic scleroderma | ||
Milatuzumab[13] | mab | humanized | CD74 | multiple myeloma and other hematological malignancies | ||
Minretumomab | mab | mouse | TAG-72 | tumor detection (and therapy?) | ||
Mirikizumab[84] | Omvoh | mab | humanized | IL-23 | Y | ulcerative colitis |
Mirvetuximab soravtansine[12] | Elahere | mab | chimeric | folate receptor alpha | Y[87] | ovarian cancer |
Mitumomab | mab | mouse | GD3 ganglioside | small cell lung carcinoma | ||
Modotuximab | mab | chimeric | EGFR extracellular domain III | cancer | ||
Mogamulizumab[16] | Poteligeo | mab | humanized | CCR4 | Y | adult T-cell leukemia/lymphoma |
Monalizumab[12] | mab | humanized | NKG2A | rheumatoid arthritis, gynecologic malignancies, and other cancers | ||
Morolimumab[88] | mab | human | Rhesus factor | |||
Mosunetuzumab[84] | Lunsumio | BiTE | humanized | CD3E, MS4A1, CD20 | Y[89] | follicular lymphoma |
Motavizumab[1] | Numax | mab | humanized | respiratory syncytial virus | respiratory syncytial virus (prevention) | |
Moxetumomab pasudotox | Lumoxiti | mab | mouse | CD22 | Y | hairy cell leukemia |
Muromonab-CD3[90][91] | Orthoclone OKT3 | mab | mouse | CD3 | prevention of organ transplant rejections | |
Nacolomab tafenatox | Fab | mouse | C242 antigen | colorectal cancer | ||
Namilumab[16] | mab | human | CSF2 | |||
Naptumomab estafenatox[92] | Fab | mouse | 5T4 | non-small cell lung carcinoma, renal cell carcinoma | ||
Naratuximab emtansine[40] | mab | chimeric | CD37 | |||
Narnatumab | mab | human | MST1R (aka RON) | cancer | ||
Natalizumab[88] | Tysabri | mab | humanized | integrin α4 | Y | multiple sclerosis, Crohn's disease |
Navicixizumab[40] | mab | chimeric/ humanized | DLL4 and VEGFA | cancer | ||
Navivumab[12] | mab | human | Hemagglutinin (influenza) | |||
Naxitamab | Danyelza | humanized | c-Met | Y | high-risk neuroblastoma and refractory osteomedullary disease | |
Nebacumab | mab | human | endotoxin | sepsis | ||
Necitumumab[93] | Portrazza | mab | human | Epidermal growth factor receptor (EGFR) | Y | non-small cell lung carcinoma |
Nemolizumab[25] | mab | humanized | IL-31 receptor A | eczema[94] | ||
NEOD001 | humanized | amyloid | primary systemic amyloidosis | |||
Nerelimomab | mab | mouse | TNF-α | |||
Nesvacumab | mab | human | angiopoietin 2 | cancer | ||
Netakimab[5] | Efleira | mab | chimeric | IL-17A | plaque psoriasis | |
Nimotuzumab[55][95] | BioMab-EGFR, Theracim, Theraloc | mab | humanized | epidermal growth factor receptor (EGFR) | Y | squamous cell carcinoma, head and neck cancer, nasopharyngeal cancer, glioma |
Nirsevimab | mab | human | RSV fusion glycoprotein | respiratory syncytial virus | ||
Nivolumab[6] | Opdivo | mab | human | PD-1 | Y | cancer |
Nofetumomab merpentan | Verluma | Fab | mouse | cancer (diagnosis) | ||
Obiltoxaximab | Anthim | mab | chimeric | Bacillus anthracis anthrax | Y | Bacillus anthracis spores |
Obinutuzumab | Gazyva | mab | humanized | CD20 | Y | chronic lymphatic leukemia |
Ocaratuzumab | mab | humanized | CD20 | cancer | ||
Ocrelizumab[96] | Ocrevus | mab | humanized | CD20 | Y | multiple sclerosis |
Odesivimab | mab | human | part of Atoltivimab/maftivimab/odesivimab for treatment of Zaire ebolavirus (Ebola virus) | |||
Odulimomab | mab | mouse | LFA-1 (CD11a) | prevention of organ transplant rejections, immunological diseases | ||
Ofatumumab[30] | Arzerra, Kesimpta[97] | mab | human | CD20 | Y | chronic lymphocytic leukemia, multiple sclerosis[97] |
Olaratumab | Lartruvo | mab | human | PDGFRA | Y | cancer |
Oleclumab[27] | mab | human | 5'-nucleotidase | pancreatic and colorectal cancer | ||
Olendalizumab[27] | mab | humanized | complement C5a | systemic lupus erythematosus, lupus nephritis, acute graft-versus-hose disease | ||
Olokizumab[72] | mab | humanized | IL-6 | rheumatoid arthritis | ||
Omalizumab[64] | Xolair | mab | humanized | IgE Fc region | Y | allergic asthma, chronic spontaneous urticaria |
Omburtamab[57] | mab | mouse | CD276 | cancer | ||
OMS721 | human | MASP-2 | atypical hemolytic uremic syndrome | |||
Onartuzumab | Fab | humanized | human scatter factor receptor kinase | cancer | ||
Ontuxizumab | mab | chimeric/ humanized | TEM1 | cancer | ||
Onvatilimab[5] | mab | human | VISTA (protein) (VSIR) | |||
Opicinumab | mab | human | LINGO-1 | multiple sclerosis | ||
Oportuzumab monatox[93] | Vicinium | scFv | humanized | EpCAM | bladder cancer | |
Oregovomab[17] | OvaRex | mab | mouse | CA-125 | ovarian cancer | |
Orticumab[15] | mab | human | oxLDL | |||
Otelixizumab[13] | mab | chimeric/ humanized | CD3 | diabetes mellitus type 1 | ||
Otilimab | mab | human | GMCSF | osteoarthritis, rheumatoid arthritis | ||
Otlertuzumab | mab | humanized | CD37 | cancer | ||
Oxelumab[41] | mab | human | OX-40 | asthma | ||
Ozanezumab | mab | humanized | NOGO-A | ALS and multiple sclerosis | ||
Ozoralizumab[41] | mab | humanized | TNF-α | inflammation | ||
Pagibaximab[30] | mab | chimeric | lipoteichoic acid | sepsis (Staphylococcus) | ||
Palivizumab | Synagis, Abbosynagis | mab | humanized | F protein of respiratory syncytial virus | Y | respiratory syncytial virus (prevention) |
Pamrevlumab[12] | mab | human | connective tissue growth factor (CTGF) | idiopathic pulmonary fibrosis (IPF), pancreatic cancer | ||
Panitumumab[65] | Vectibix | mab | human | epidermal growth factor receptor (EGFR) | Y | colorectal cancer |
Pankomab | mab | humanized | tumor specific glycosylation of MUC1 | ovarian cancer | ||
Panobacumab[93] | mab | human | Pseudomonas aeruginosa | Pseudomonas aeruginosa infection | ||
Parsatuzumab[15] | mab | humanized | EGFL7 | cancer | ||
Pascolizumab[21] | mab | humanized | IL-4 | asthma | ||
Pasotuxizumab[6] | mab | chimeric/ humanized | folate hydrolase | cancer | ||
Pateclizumab[41] | mab | humanized | lymphotoxin alpha (LTA) | TNF | ||
Patritumab[43] | mab | human | ERBB3 (HER3) | cancer | ||
PDR001 | humanized | PD-1 | melanoma | |||
Pembrolizumab[52] | Keytruda | mab | humanized | PD-1 | Y[98] | melanoma and other cancers |
Pemtumomab | Theragyn | mouse | MUC1 | cancer | ||
Perakizumab[15] | mab | humanized | IL-17A | arthritis | ||
Pertuzumab | Perjeta | mab | humanized | HER2/neu | Y | cancer |
Pexelizumab[17] | scFv | humanized | C5 | reduction of side effects of cardiac surgery | ||
Pidilizumab[39] | mab | humanized | PD-1 | cancer and infectious diseases | ||
Pinatuzumab vedotin[39] | mab | humanized | CD22 | cancer | ||
Pintumomab | mab | mouse | adenocarcinoma antigen | adenocarcinoma (imaging) | ||
Placulumab[15] | mab | human | TNF | pain and inflammatory diseases | ||
Pozelimab[34] | Veopoz | mab | human | C5 | Y | CHAPLE disease |
Prezalumab[40] | mab | human | TNF | |||
Plozalizumab[12] | mab | humanized | CCR2 | diabetic nephropathy and arteriovenous graft patency | ||
Pogalizumab[40] | mab | humanized | tumor necrosis factor receptor (TNFR) superfamily member 4 | |||
Polatuzumab vedotin[50][4] | Polivy | mab | humanized | CD79B | Y | diffuse large B-cell lymphoma |
Ponezumab | mab | humanized | β-amyloid | Alzheimer's disease | ||
Porgaviximab[27] | mab | chimeric | Zaire ebolavirus glycoprotein | Ebola virus disease | ||
Prasinezumab[26] | mab | humanized | Alpha-synuclein | Parkinson's disease | ||
Prezalizumab[40] | mab | humanized | inducible T-cell co-stimulatory ligand (ICOSL) | |||
Priliximab | mab | chimeric | CD4 | Crohn's disease, multiple sclerosis | ||
Pritoxaximab[39] | mab | chimeric | E. coli shiga toxin type-1 | |||
Pritumumab | mab | human | vimentin | brain cancer | ||
PRO 140 | humanized | CCR5 | HIV infection | |||
Quilizumab[43] | mab | humanized | IGHE | asthma | ||
Racotumomab[93] | Vaxira | mab | mouse | NGNA ganglioside | Y | non-small cell lung cancer |
Radretumab[16] | mab | human | fibronectin extra domain-B | cancer | ||
Rafivirumab[48] | mab | human | rabies virus glycoprotein | rabies (prophylaxis) | ||
Ralpancizumab | mab | humanized | PCSK9 | dyslipidemia | ||
Ramucirumab | Cyramza | mab | human | VEGFR2 | Y | solid tumors |
Ranevetmab | mab | veterinary | NGF | osteoarthritis in dogs | ||
Ranibizumab[9] | Lucentis | Fab | humanized | VEGF-A | Y | macular degeneration (wet form) |
Raxibacumab[38] | mab | human | anthrax toxin, protective antigen | Y | anthrax (prophylaxis and treatment) | |
Ravagalimab[5] | mab | humanized | CD40 | Crohn's disease | ||
Ravulizumab[26] | Ultomiris | mab | humanized | C5 | Y | paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome |
Refanezumab | mab | humanized | myelin-associated glycoprotein | recovery of motor function after stroke | ||
Regavirumab | mab | human | cytomegalovirus glycoprotein B | cytomegalovirus infection | ||
Regdanvimab[28] | Regkirona[99] | mab | human | spike protein receptor binding domain (RBD) of SARS-CoV-2 | Y[99] | COVID-19 |
Relatlimab | mab | human | LAG3 | melanoma | ||
Remtolumab[22] | mab | human | IL-17A, TNF | |||
Reslizumab[7] | Cinqair | mab | humanized | IL-5 | Y | inflammations of the airways, skin and gastrointestinal tract |
Retifanlimab[60] | Zynyz[100] | mab | humanized | PD-1 | Y | Merkel cell carcinoma |
Rilotumumab | mab | human | hepatocyte growth factor (HGF) | solid tumors | ||
Rinucumab | mab | human | PDGFRB | neovascular age-related macular degeneration | ||
Risankizumab[12] | Skyrizi | mab | humanized | IL-23A | Y | Crohn's disease, psoriasis, psoriatic arthritis, and asthma |
Rituximab | MabThera, Rituxan | mab | chimeric | CD20 | Y[101] | lymphomas, leukemias, some autoimmune disorders |
Rivabazumab pegol[12] | mab | humanized | Pseudomonas aeruginosa type III secretion system | |||
Robatumumab | mab | human | IGF-1 receptor (CD221) | cancer | ||
Rmab | RabiShield | human | rabies virus G glycoprotein | Y | post-exposure prophylaxis of rabies | |
Roledumab[72] | mab | human | RHD (gene) (RHD) | Rh disease | ||
Romilkimab[5] | mab | chimeric/ humanized | IL-13 | |||
Romosozumab | Evenity | mab | humanized | sclerostin | Y | osteoporosis |
Rontalizumab[53] | mab | humanized | IFN-α | systemic lupus erythematosus | ||
Rosmantuzumab[22] | mab | humanized | root plate-specific spondin 3 | cancer | ||
Rovalpituzumab tesirine[12] | mab | humanized | DLL3 | small cell lung cancer | ||
Rovelizumab[46] | LeukArrest | mab | humanized | CD11, CD18 | Y | haemorrhagic shock etc. |
Rozanolixizumab[22] | Rystiggo | mab | chimeric/ humanized | FCGRT | Y[102] | myasthenia gravis |
Ruplizumab[14] | Antova | mab | humanized | CD154 (CD40L) | Y | rheumatic diseases |
SA237 | humanized | IL-6 receptor | neuromyelitis optica and neuromyelitis optica spectrum disorders | |||
Sacituzumab govitecan[22] | Trodelvy | mab | humanized | TROP-2 | Y[103] | triple-negative breast cancer |
Samalizumab[41] | mab | humanized | CD200 | cancer | ||
Samrotamab vedotin[5] | mab | chimeric/ humanized | LRRC15 | cancer | ||
Sarilumab[43] | Kevzara | mab | human | IL-6 | Y | rheumatoid arthritis, ankylosing spondylitis |
Satralizumab[73] | Enspryng | mab | humanized | IL-6 receptor | Y | neuromyelitis optica |
Satumomab pendetide | mab | mouse | TAG-72 | cancer (diagnosis) | ||
Secukinumab | Cosentyx | mab | human | IL-17A | Y | uveitis, rheumatoid arthritis psoriasis |
Selicrelumab[27] | mab | human | CD40 | |||
Seribantumab[39] | mab | human | ERBB3 (HER3) | cancer | ||
Setoxaximab[39] | mab | chimeric | E. coli shiga toxin type-2 | |||
Setrusumab[26] | mab | human | sclerostin (SOST) | |||
Sevirumab | human | cytomegalovirus | cytomegalovirus infection | |||
Sibrotuzumab | mab | humanized | FAP (gene) (FAP) | cancer | ||
SGN-CD19A | mab | humanized | CD19 | acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma | ||
SHP647 | human | mucosal addressin cell adhesion molecule | Crohn's disease | |||
Sifalimumab[16] | mab | human | IFN-α | systemic lupus erythematosus (SLE), dermatomyositis, polymyositis | ||
Siltuximab | Sylvant | mab | chimeric | IL-6 | Y | cancer |
Simtuzumab[15] | mab | humanized | LOXL2 | fibrosis | ||
Siplizumab[21] | mab | humanized | CD2 | psoriasis, graft-versus-host disease (prevention) | ||
Sirtratumab vedotin[26] | mab | human | SLITRK6 | cancer | ||
Sirukumab | mab | human | IL-6 | rheumatoid arthritis | ||
Sofituzumab vedotin | mab | humanized | CA-125 | ovarian cancer | ||
Solanezumab[93] | mab | humanized | β-amyloid | Alzheimer's disease | ||
Solitomab[43] | BiTE | mouse | EpCAM | gastrointestinal, lung, and other cancers | ||
Sonepcizumab[104] | humanized | sphingosine-1-phosphate | choroidal and retinal neovascularization | |||
Sontuzumab[95] | mab | humanized | episialin | |||
Sotrovimab[28] | Xevudy | mab | human | spike protein receptor binding domain (RBD) of SARS-CoV-2 | Y[105][106] | COVID-19 |
Spartalizumab[26] | mab | humanized | PD-1 | melanoma | ||
Spesolimab[107] | Spevigo | mab | humanized | Interleukin 36 receptor (IL1RL2/IL1RAP) | Y | generalized pustular psoriasis (GPP) |
Stamulumab[96] | mab | human | myostatin | muscular dystrophy | ||
Sulesomab | LeukoScan | Fab' | mouse | NCA-90 (granulocyte antigen) | osteomyelitis (imaging) | |
Suptavumab[22] | mab | human | RSVFR | medically attended lower respiratory disease | ||
Sutimlimab[66] | Enjaymo | mab | chimeric/ humanized | complement component 1s (C1s) | Y | cold agglutinin disease |
Suvizumab[37] | mab | humanized | HIV-1 | viral infections | ||
Suvratoxumab[27] | mab | human | Staphylococcus aureus alpha toxin | nosocomial pneumonia | ||
Tabalumab[41] | mab | human | B-cell activating factor (BAFF) | B-cell cancers | ||
Tacatuzumab tetraxetan | AFP-Cide | mab | humanized | alpha-fetoprotein | cancer | |
Tadocizumab[95] | Fab | humanized | integrin αIIbβ3 | percutaneous coronary intervention | ||
Tafasitamab[46] | Monjuvi | mab | humanized (from mouse) | CD19 | Y | relapsed or refractory diffuse large B-cell lymphoma |
Talacotuzumab[26] | mab | humanized | CD123 | leukemia etc. | ||
Talizumab[36] | mab | humanized | IgE | allergic reaction | ||
Talquetamab | Talvey | BsAb | humanized | GPRC5D, CD3 | Y | relapsed or refractory multiple myeloma |
Tamtuvetmab[40] | Tactress | mab | veterinary | CD52 | ||
Tanezumab[48] | mab | humanized | nerve growth factor (NGF) | pain | ||
Taplitumomab paptox[64] | mab | mouse | CD19 | cancer | ||
Tarextumab | mab | human | Notch receptor | cancer | ||
Tavolimab | mab | chimeric/ humanized | CD134 | cancer | ||
Teclistamab | Tecvayli[34] | BsAb | human | B-cell maturation antigen (BCMA), CD3 | Y[108][109] | relapsed or refractory multiple myeloma |
Tefibazumab[38] | Aurexis | mab | humanized | clumping factor A | Staphylococcus aureus infection | |
Telimomab aritox | Fab | mouse | ||||
Telisotuzumab[22] | mab | humanized | HGFR | cancer | ||
Telisotuzumab vedotin[22] | mab | humanized | HGFR | cancer | ||
Tenatumomab[13] | mab | mouse | tenascin C | cancer | ||
Teneliximab[21] | mab | chimeric | CD40 | autoimmune diseases and prevention of organ transplant rejection | ||
Teplizumab[42] | Tzield | mab | humanized | CD3 | Y | diabetes mellitus type 1 |
Tepoditamab[5] | mab | human | dendritic cell-associated lectin 2 | cancer | ||
Teprotumumab | Tepezza | mab | human | IGF-1 receptor (CD221) | Y | thyroid eye disease |
Tesidolumab[25] | mab | human | C5 | |||
Tetulomab | mab | humanized | CD37 | cancer[110] | ||
Tezepelumab[12] | Tezspire | mab | human | thymic stromal lymphopoietin (TSLP) | Y[111] | asthma |
TGN1412 | humanized | CD28 | chronic lymphocytic leukemia, rheumatoid arthritis | |||
Tibulizumab[26] | mab | humanized | B-cell activating factor (BAFF) | autoimmune disorders | ||
Tildrakizumab | Ilumya | mab | humanized | IL-23 | Y | immunologically mediated inflammatory disorders |
Tigatuzumab[13] | mab | humanized | TRAIL-R2 | cancer | ||
Timigutuzumab[27] | mab | humanized | HER2 | cancer | ||
Timolumab[40] | mab | human | AOC3 | |||
tiragolumab[26] | mab | human | ||||
Tiragotumab[26] | mab | human | TIGIT | cancer | ||
Tislelizumab[26] | mab | humanized | PCDC1, CD279 | non-small cell lung cancer | ||
Tisotumab vedotin[12] | Tivdak | mab | human | coagulation factor III | Y | relapsed or refractory cervical cancer[112][113] |
Tixagevimab[28] | mab | human | spike protein receptor binding domain (RBD) of SARS-CoV-2 | Emergency Use Authorization (EUA) when used with cilgavimab[47] | COVID-19 | |
TNX-650 | humanized | IL-13 | Hodgkin's lymphoma | |||
Tocilizumab[9] | Actemra, RoActemra | mab | humanized | IL-6 receptor | Y[114] | rheumatoid arthritis |
Tomuzotuximab[27] | mab | humanized | Epidermal growth factor receptor (EGFR), HER1 | cancer | ||
Toralizumab[21] | mab | humanized | CD154 (CD40L) | rheumatoid arthritis, lupus nephritis etc. | ||
Tosatoxumab[4] | mab | human | Staphylococcus aureus | |||
Tositumomab | Bexxar | mouse | CD20 | Y | follicular lymphoma | |
Tovetumab | mab | human | PDGFRA | cancer | ||
Tralokinumab[115] | Adtralza, Adbry[116] | mab | human | IL-13 | Y[116] | atopic dermatitis |
Trastuzumab | Herceptin | mab | humanized | HER2/neu | Y | breast cancer |
Trastuzumab duocarmazine[22] | Kadcyla | mab | humanized | HER2/neu | Y | breast cancer |
Trastuzumab emtansine | Kadcyla | mab | humanized | HER2/neu | Y | breast cancer |
TRBS07[117] | Ektomab | 3funct | GD2 ganglioside | melanoma | ||
Tregalizumab[16] | mab | humanized | CD4 | |||
Tremelimumab[118] | Imjudo | mab | human | CTLA-4 | Y[119] | hepatocellular carcinoma |
Trevogrumab | mab | human | growth differentiation factor 8 | muscle atrophy due to orthopedic disuse and sarcopenia | ||
Tucotuzumab celmoleukin[55][95] | mab | humanized | EpCAM | cancer | ||
Tuvirumab | human | hepatitis B virus | chronic hepatitis B | |||
Ublituximab[120] | Briumvi | mab | chimeric | CD20 | Y | multiple sclerosis, chronic lymphocytic leukemia |
Ulocuplumab[52] | mab | human | CXCR4 (CD184) | hematologic malignancies | ||
Urelumab[16] | mab | human | 4-1BB (CD137) | cancer etc. | ||
Urtoxazumab[9] | mab | humanized | Escherichia coli | diarrhoea caused by E. coli | ||
Ustekinumab[48] | Stelara | mab | human | IL-12, IL-23 | Y | multiple sclerosis, psoriasis, psoriatic arthritis |
Utomilumab[22] | mab | human | 4-1BB (CD137) | diffuse large B-cell lymphoma | ||
Vadastuximab talirine[12] | mab | chimeric | CD33 | Acute myeloid leukemia | ||
Vanalimab[5] | mab | humanized | CD40 | |||
Vandortuzumab vedotin[25] | mab | humanized | STEAP1 | cancer | ||
Vantictumab | mab | human | Frizzled receptor | cancer | ||
Vanucizumab[6] | mab | humanized | angiopoietin 2 | cancer | ||
Vapaliximab[21] | mab | chimeric | AOC3 (VAP-1) | |||
Varisacumab[27] | mab | human | VEGF-A | angiogenesis | ||
Varlilumab[6] | mab | human | CD27 | solid tumors and hematologic malignancies | ||
Vatelizumab[41] | mab | humanized | ITGA2 (CD49b) | |||
Vedolizumab[93] | Entyvio | mab | humanized | integrin α4 β7 | Y[121] | Crohn's disease, ulcerative colitis |
Veltuzumab[13] | mab | humanized | CD20 | non-Hodgkin's lymphoma | ||
Vepalimomab | mab | mouse | AOC3 (VAP-1) | inflammation | ||
Vesencumab[16] | mab | human | NRP1 | solid malignancies | ||
Vilobelimab[82] | Gohibic | mab | chimeric | C5a receptor (C5a) | Emergency Use Authorization (EUA)[122] | COVID-19 |
Visilizumab[64] | Nuvion | mab | humanized | CD3 | Crohn's disease, ulcerative colitis | |
Vobarilizumab[40] | scFv | humanized | IL-6 receptor | inflammatory autoimmune diseases | ||
Volociximab[30] | mab | chimeric | integrin α5β1 | solid tumors | ||
Vonlerolizumab[27] | mab | humanized | CD134 | cancer | ||
Vopratelimab[5] | mab | humanized | CD278, aka ICOS | |||
Vorsetuzumab mafodotin | mab | humanized | CD70 | cancer | ||
Votumumab | HumaSPECT | mab | human | tumor antigen CTAA16.88 | colorectal tumors | |
Vunakizumab[22] | mab | humanized | IL-17A | |||
Xentuzumab[40] | mab | humanized | IGF-1, IGF-2 | ? | ||
XMAB-5574 | humanized | CD19 | diffuse large B-cell lymphoma | |||
Zalutumumab[30] | mab | human | Epidermal growth factor receptor (EGFR) | squamous cell carcinoma of the head and neck | ||
Zanolimumab[38] | mab | human | CD4 | rheumatoid arthritis, psoriasis, T-cell lymphoma | ||
Zatuximab[15] | mab | chimeric | HER1 | cancer | ||
Zenocutuzumab[26] | mab | humanized | ERBB3 (HER3) | cancer | ||
Ziralimumab[64] | mab | human | CD147 (basigin) | |||
Zolbetuximab[26] | mab | chimeric | Claudin 18 Isoform 2 | gastric cancer, gastrointestinal adenocarcinoma and pancreatic cancer | ||
Zolimomab aritox | mab | mouse | CD5 | systemic lupus erythematosus, graft-versus-host disease |
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