N,N-Didesmethyltamoxifen

N,N-Desmethyltamoxifen is a metabolite of tamoxifen, a selective estrogen receptor modulator (SERM).[1] It is formed from N-desmethyltamoxifen and is an intermediate in the conversion of tamoxifen and N-desmethyltamoxifen into norendoxifen (4-hydroxy-N,N-desmethyltamoxifen), an active metabolite of tamoxifen.[1]

N,N-Didesmethyltamoxifen
Clinical data
Other namesDinortamoxifen
Identifiers
  • 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]ethanamine
CAS Number
PubChem CID
ChemSpider
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC24H25NO
Molar mass343.470 g·mol−1
3D model (JSmol)
  • CC/C(=C(\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN)/C3=CC=CC=C3
  • InChI=1S/C24H25NO/c1-2-23(19-9-5-3-6-10-19)24(20-11-7-4-8-12-20)21-13-15-22(16-14-21)26-18-17-25/h3-16H,2,17-18,25H2,1H3/b24-23-
  • Key:MCJKBWHDNUSJLW-VHXPQNKSSA-N

References
  1. Sanchez-Spitman AB, Swen JJ, Dezentje VO, Moes DJ, Gelderblom H, Guchelaar HJ (June 2019). "Clinical pharmacokinetics and pharmacogenetics of tamoxifen and endoxifen". Expert Review of Clinical Pharmacology. 12 (6): 523–536. doi:10.1080/17512433.2019.1610390. PMID 31008668.



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