Gem-associated protein 2

Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that in humans is encoded by the GEMIN2 gene.[5][6][7]

GEMIN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGEMIN2, SIP1, SIP1-delta, Survival of motor neuron protein-interacting protein 1, gem nuclear organelle associated protein 2
External IDsOMIM: 602595 MGI: 1913853 HomoloGene: 37827 GeneCards: GEMIN2
Orthologs
SpeciesHumanMouse
Entrez

8487

66603

Ensembl

ENSG00000092208

ENSMUSG00000060121

UniProt

O14893

Q9CQQ4

RefSeq (mRNA)

NM_001009182
NM_001009183
NM_003616

NM_025656

RefSeq (protein)

NP_001009182
NP_001009183
NP_003607

NP_079932

Location (UCSC)Chr 14: 39.11 – 39.14 MbChr 12: 59.06 – 59.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

Gem-associated protein 2 has been shown to interact with DDX20[8][9] and SMN1.[6][10][11]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000092208 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000060121 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fischer U, Liu Q, Dreyfuss G (September 1997). "The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis". Cell. 90 (6): 1023–1029. doi:10.1016/S0092-8674(00)80368-2. PMID 9323130.
  6. Liu Q, Fischer U, Wang F, Dreyfuss G (September 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–1021. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129.
  7. "Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1".
  8. Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, et al. (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes & Development. 16 (6): 720–728. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.
  9. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–1194. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
  10. Carnegie GK, Sleeman JE, Morrice N, Hastie CJ, Peggie MW, Philp A, et al. (May 2003). "Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs". Journal of Cell Science. 116 (Pt 10): 1905–1913. doi:10.1242/jcs.00409. PMID 12668731.
  11. Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Human Molecular Genetics. 9 (13): 1977–1986. doi:10.1093/hmg/9.13.1977. PMID 10942426.

Further reading

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