3,4-Dihydroxystyrene

3,4-Dihydroxystyrene
Clinical data
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 4-Ethenylbenzene-1,2-diol;
CAS Number	6053-02-7 ;
PubChem CID	151398;
ChemSpider	133430 ;
UNII	28C0I29E70;
KEGG	C06224 ;
CompTox Dashboard (EPA)	DTXSID20209275 ;
Chemical and physical data
Formula	C8H8O2
Molar mass	136.150 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1ccc(\C=C)cc1O;
	InChI InChI=1S/C8H8O2/c1-2-6-3-4-7(9)8(10)5-6/h2-5,9-10H,1H2 ; Key:FBTSUTGMWBDAAC-UHFFFAOYSA-N ;
	(what is this?) (verify)

3,4-Dihydroxystyrene (DHS) is a centrally-acting inhibitor of the enzyme phenylalanine hydroxylase (PH).[1] It is likely that DHS and other PH inhibitors will never have clinical applications on account of their capacity for inducing hyperphenylalaninemia and phenylketonuria.

References

Koizumi S, Matsushima Y, Nagatsu T, Iinuma H, Takeuchi T, Umezawa H (September 1984). "3,4-dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 789 (2): 111–8. doi:10.1016/0167-4838(84)90194-8. PMID 6148105.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.