Cimoxatone

Cimoxatone (MD 780515) is a reversible inhibitor of MAO-A (RIMA).[1] It has a significant food interaction–related adverse effect in combination with tyramine.[2] It was never marketed.

Cimoxatone
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • 3-[[4-[5-(methoxymethyl)-2-oxo-oxazolidin-3-yl]phenoxy]methyl]benzonitrile
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard100.070.537
Chemical and physical data
FormulaC19H18N2O4
Molar mass338.363 g·mol−1
InChI
  • InChI=1S/C19H18N2O4/c1-23-13-18-11-21(19(22)25-18)16-5-7-17(8-6-16)24-12-15-4-2-3-14(9-15)10-20/h2-9,18H,11-13H2,1H3 Y
  • Key:MVVJINIUPYKZHR-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

See also

References
  1. Nair NP, Ahmed SK, Kin NM, West TE (1995). "Reversible and selective inhibitors of monoamine oxidase A in the treatment of depressed elderly patients". Acta Psychiatr Scand Suppl. 386: 28–35. doi:10.1111/j.1600-0447.1995.tb05921.x. PMID 7717092. S2CID 9100689.
  2. Nair NP, Ahmed SK, Kin NM (November 1993). "Biochemistry and pharmacology of reversible inhibitors of MAO-A agents: focus on moclobemide". J Psychiatry Neurosci. 18 (5): 214–25. PMC 1188542. PMID 7905288.
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