3,4-Dihydroxystyrene
3,4-Dihydroxystyrene (DHS) is a centrally-acting inhibitor of the enzyme phenylalanine hydroxylase (PH).[1] It is likely that DHS and other PH inhibitors will never have clinical applications on account of their capacity for inducing hyperphenylalaninemia and phenylketonuria.
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Formula | C8H8O2 |
Molar mass | 136.150 g·mol−1 |
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References
- Koizumi S, Matsushima Y, Nagatsu T, Iinuma H, Takeuchi T, Umezawa H (September 1984). "3,4-dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 789 (2): 111–8. doi:10.1016/0167-4838(84)90194-8. PMID 6148105.
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