ATC-0175

ATC-0175 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has been shown to produce both anxiolytic and antidepressant actions, but without sedative or ataxic side effects.[1][2][3]

ATC-0175
Identifiers
IUPAC name
  • N-[cis-4-([4-(dimethylamino)quinazolin-2-yl]amino)cyclohexyl]-3,4-difluorobenzamide
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
Chemical and physical data
FormulaC23H25F2N5O
Molar mass425.473 g·mol−1
3D model (JSmol)
SMILES
  • Fc1ccc(cc1F)C(=O)NC3CCC(CC3)Nc(nc4N(C)C)nc2ccccc24
InChI
  • InChI=1S/C23H25F2N5O/c1-30(2)21-17-5-3-4-6-20(17)28-23(29-21)27-16-10-8-15(9-11-16)26-22(31)14-7-12-18(24)19(25)13-14/h3-7,12-13,15-16H,8-11H2,1-2H3,(H,26,31)(H,27,28,29) Y
  • Key:FAIMGWSOSCFGRU-UHFFFAOYSA-N Y
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References
  1. Chaki S, Funakoshi T, Hirota-Okuno S, Nishiguchi M, Shimazaki T, Iijima M, Grottick AJ, Kanuma K, Omodera K, Sekiguchi Y, Okuyama S, Tran TA, Semple G, Thomsen W (May 2005). "Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists". The Journal of Pharmacology and Experimental Therapeutics. 313 (2): 831–9. doi:10.1124/jpet.104.081711. PMID 15677346. S2CID 23023526.
  2. Kanuma K, Omodera K, Nishiguchi M, Funakoshi T, Chaki S, Semple G, Tran TA, Kramer B, Hsu D, Casper M, Thomsen B, Sekiguchi Y (September 2005). "Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1". Bioorganic & Medicinal Chemistry Letters. 15 (17): 3853–6. doi:10.1016/j.bmcl.2005.05.121. PMID 16002290.
  3. Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y (2005). "ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety". CNS Drug Reviews. 11 (4): 341–52. doi:10.1111/j.1527-3458.2005.tb00052.x. PMC 6741758. PMID 16614734.


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