Ligelizumab

Ligelizumab
Monoclonal antibody
Type	Whole antibody
Source	Humanized (from mouse)
Target	IGHE
Clinical data
Other names	QGE031
ATC code	none;
Identifiers
CAS Number	1322627-61-1;
ChemSpider	none;
UNII	L8LE0L691T;
KEGG	D11761;
Chemical and physical data
Formula	C6534H10000N1716O2038S44
Molar mass	146612.49 g·mol−1

Ligelizumab (INN; development code QGE031) is a humanized IgG1 monoclonal antibody designed for the treatment of severe asthma and chronic spontaneous urticaria.[1] It is an anti-IgE that binds to IGHE an acts as an immunomodulator.[2][3]

This drug was developed by Novartis Pharma AG. Research funded by Novartis Pharma[4] concluded that Ligelizumab was more effective in treating chronic spontaneous urticaria than omalizumab or placebo.[5]

References

Statement On A Nonproprietary Name Adopted By The USAN Council - Ligelizumab, American Medical Association.
"International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 107" (PDF). WHO Drug Information. 26 (2). 2012.
Kocatürk, Emek; Maurer, Marcus; Metz, Martin; Grattan, Clive (2017-01-10). "Looking forward to new targeted treatments for chronic spontaneous urticaria". Clinical and Translational Allergy. 7: 1. doi:10.1186/s13601-016-0139-2. ISSN 2045-7022. PMC 5223554. PMID 28078079.
Novartis Pharmaceuticals (2018-10-02). "A Multi-center, Randomized, Double-blind, Placebo, and Active-controlled Phase 2b Dose-finding Study of QGE031 as add-on Therapy to Investigate the Efficacy and Safety in Patients With Chronic Spontaneous Urticaria (CSU)". {{cite journal}}: Cite journal requires |journal= (help)
Maurer M, Giménez-Arnau AM, Sussman G, Metz M, Baker DR, Bauer A, et al. (October 2019). "Ligelizumab for Chronic Spontaneous Urticaria". The New England Journal of Medicine. 381 (14): 1321–1332. doi:10.1056/NEJMoa1900408. PMID 31577874.

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[1] Statement On A Nonproprietary Name Adopted By The USAN Council - Ligelizumab, American Medical Association.

[2] "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 107" (PDF). WHO Drug Information. 26 (2). 2012.

[3] Kocatürk, Emek; Maurer, Marcus; Metz, Martin; Grattan, Clive (2017-01-10). "Looking forward to new targeted treatments for chronic spontaneous urticaria". Clinical and Translational Allergy. 7: 1. doi:10.1186/s13601-016-0139-2. ISSN 2045-7022. PMC 5223554. PMID 28078079.

[4] Novartis Pharmaceuticals (2018-10-02). "A Multi-center, Randomized, Double-blind, Placebo, and Active-controlled Phase 2b Dose-finding Study of QGE031 as add-on Therapy to Investigate the Efficacy and Safety in Patients With Chronic Spontaneous Urticaria (CSU)". {{cite journal}}: Cite journal requires |journal= (help)

[5] Maurer M, Giménez-Arnau AM, Sussman G, Metz M, Baker DR, Bauer A, et al. (October 2019). "Ligelizumab for Chronic Spontaneous Urticaria". The New England Journal of Medicine. 381 (14): 1321–1332. doi:10.1056/NEJMoa1900408. PMID 31577874.