Zanolimumab
Zanolimumab (expected trade name HuMax-CD4[1]) is a human monoclonal antibody and an immunosuppressive drug.[2] It was developed with the goal of treatment of rheumatoid arthritis, psoriasis, melanoma,[3] cutaneous and peripheral T-cell lymphoma.[4][5] Development of the drug was ultimately discontinued with termination of all trials.[6]
| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Human |
| Target | CD4 |
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| Molar mass | 147 kg/mol |
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References
- Genmab initiates Phase II Study with HuMax-CD4 Archived May 16, 2008, at the Wayback Machine
- Mestel DS, Beyer M, Möbs M, Steinhoff M, Sterry W, Assaf C (December 2008). "Zanolimumab, a human monoclonal antibody targeting CD4 in the treatment of mycosis fungoides and Sézary syndrome". Expert Opinion on Biological Therapy. 8 (12): 1929–39. doi:10.1517/14712590802528696. PMID 18990079. S2CID 58115371.
- "TenX BioPharma". Archived from the original on April 11, 2010. Retrieved August 20, 2010.
- Statement On A Nonproprietary Name Adopted By The USAN Council - Zanolimumab, American Medical Association.
- Clinical trial number NCT00042406 for "Trial With HuMax-CD4 in Patients With Rheumatoid Arthritis Failing Treatment With Methotrexate and a TNF-Alpha Blocker" at ClinicalTrials.gov
- "Status of clinical trials for Zanolimumab". Retrieved 6 November 2011.
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