Olokizumab

Olokizumab is an immunomodulator. It binds to interleukin 6.[1] Hence acting as an Anti-IL-6 therapeutic aimed at inflammatory disease e.g. rheumatoid arthritis (RA).

Olokizumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized
TargetIL6
Clinical data
ATC code
  • None
Identifiers
CAS Number
ChemSpider
  • none
UNII
 NY (what is this?)  (verify)

It had promising results in a phase II trial against placebo or tocilizumab for patients with moderate to severe whan.[2][3]

Olokizumab was approved for medical use in Russia. On May 21, 2020, the Russian Health Ministry approved brand name Artlegia (olokizumab).

Olokizumab (64 mg once) is used as emergence experimental cytokine storm COVID-19 complications treatment.[4]

In a 24-week, Phase 3, multicenter, placebo- and active-controlled trial, olokizumab (at a dose of 64 mg every 2 or 4 weeks) was superior to placebo and noninferior to adalimumab in producing a response at 12 weeks.[5]

References
  1. World Health Organization (2010). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 103" (PDF). WHO Drug Information.
  2. Walsh N (6 August 2014). "RheumShorts: IL-6 and RA, Life and Death, Surgery in Lupus".
  3. Genovese MC, Fleischmann R, Furst D, Janssen N, Carter J, Dasgupta B, et al. (September 2014). "Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study". Annals of the Rheumatic Diseases. 73 (9): 1607–15. doi:10.1136/annrheumdis-2013-204760. PMC 4145439. PMID 24641941.
  4. Marrow, Alexander (8 October 2020). "Russia's R-Pharm retools arthritis drug for COVID-19 patients in clinical trial". Reuters.
  5. Smolen, Josef S.; Feist, Eugen; Fatenejad, Saeed; Grishin, Sergey A.; Korneva, Elena V.; Nasonov, Evgeniy L.; Samsonov, Mikhail Y.; Fleischmann, Roy M. (2022-08-24). "Olokizumab versus Placebo or Adalimumab in Rheumatoid Arthritis". New England Journal of Medicine. doi:10.1056/NEJMoa2201302.
  • "Olokizumab". Drug Information Portal. U.S. National Library of Medicine.


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