Denileukin diftitox
Denileukin diftitox (trade name Ontak) was an antineoplastic agent, an engineered protein combining interleukin-2 and diphtheria toxin. Denileukin diftitox could bind to interleukin-2 receptors[1] and introduce the diphtheria toxin into cells that express those receptors, killing the cells. In some leukemias and lymphomas, malignant cells express these receptors, so denileukin diftitox can target these.
| Clinical data | |
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| Trade names | Ontak |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a611024 |
| Routes of administration | Intravenous |
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| Pharmacokinetic data | |
| Elimination half-life | 70-80 min |
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| Formula | C2560H4042N678O799S17 |
| Molar mass | 57647.46 g·mol−1 |
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In 1999, Ontak was approved by the U.S. Food and Drug Administration (FDA) for treatment of Cutaneous T-cell lymphoma (CTCL).[2]
There is some evidence tying it to vision loss, and in 2006 the FDA added a black box warning to the drug's label.[3]
In 2014, marketing of Ontak was discontinued in the US.[4]
References
- Turturro F (January 2007). "Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders". Expert Review of Anticancer Therapy. 7 (1): 11–7. doi:10.1586/14737140.7.1.11. PMID 17187516. S2CID 9028829.
- Manoukian G, Hagemeister F (November 2009). "Denileukin diftitox: a novel immunotoxin". Expert Opinion on Biological Therapy. 9 (11): 1445–51. doi:10.1517/14712590903348135. PMID 19817678. S2CID 23956460.
- Lansigan F, Stearns DM, Foss F (February 2010). "Role of denileukin diftitox in the treatment of persistent or recurrent cutaneous T-cell lymphoma". Cancer Management and Research. 2: 53–9. doi:10.2147/cmar.s5009. PMC 3004568. PMID 21188096.
- "FDA Drug Shortages". U.S. Food and Drug Administration. 31 January 2014. Retrieved 3 July 2017.
External links
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