SNAP-94847

SNAP-94847 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has been shown to produce both anxiolytic and antidepressant effects,[1][2] and also reduces food consumption suggesting a possible anorectic effect.[3]

SNAP-94847
Identifiers
IUPAC name
  • N-(3-[1-([4-(3,4-difluorophenoxy)phenyl]methyl)(4-piperidyl)]-4-methylphenyl)-2-methylpropanamide
ChemSpider
ECHA InfoCard100.230.605
Chemical and physical data
FormulaC29H32F2N2O2
Molar mass478.572 g·mol−1
3D model (JSmol)
SMILES
  • Fc1ccc(cc1F)Oc(cc4)ccc4CN(CC3)CCC3c2cc(NC(=O)C(C)C)ccc2C
InChI
  • InChI=1S/C29H32F2N2O2/c1-19(2)29(34)32-23-7-4-20(3)26(16-23)22-12-14-33(15-13-22)18-21-5-8-24(9-6-21)35-25-10-11-27(30)28(31)17-25/h4-11,16-17,19,22H,12-15,18H2,1-3H3,(H,32,34)
  • Key:VMLZFUVIKCGATC-UHFFFAOYSA-N
  (verify)

References
  1. David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R (April 2007). "Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis". The Journal of Pharmacology and Experimental Therapeutics. 321 (1): 237–48. doi:10.1124/jpet.106.109678. PMID 17237257. S2CID 717425.
  2. Smith DG, Hegde LG, Wolinsky TD, Miller S, Papp M, Ping X, Edwards T, Gerald CP, Craig DA (February 2009). "The effects of stressful stimuli and hypothalamic-pituitary-adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP 94847 in rodents". Behavioural Brain Research. 197 (2): 284–91. doi:10.1016/j.bbr.2008.08.026. PMID 18793675. S2CID 205878561.
  3. Nair SG, Adams-Deutsch T, Pickens CL, Smith DG, Shaham Y (July 2009). "Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats". Psychopharmacology. 205 (1): 129–40. doi:10.1007/s00213-009-1523-6. PMC 3143407. PMID 19340414.


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