Activated protein C–protein C inhibitor

Activated protein C–protein C inhibitor (APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI).[1][2][3] It has been measured in coagulation testing to evaluate coagulation, thrombosis, and other cardiovascular complications.[2][3][4] It is a marker of thrombin generation and indicates hypercoagulability.[1][5] The half-life of APC-PCI is either 40 minutes or 140 minutes.[1]

Ethinylestradiol-containing birth control pills have been found to increase levels of APC-PCI to a similar degree as thrombin–antithrombin complex (TAT) and to a greater extent than D-dimer.[5] However, only APC-PCI was able to differentiate between a second- and third-generation birth control pill.[5]

Another complex related to APC-PCI is the activated protein C–α1-antitrypsin (APCAT) complex.[1]

References

  1. 1 2 3 4 Merlini PA, Ardissino D (1995). "Laboratory Measurement of Thrombin Activity--What Every Clinician Scientist Needs to Know". J Thromb Thrombolysis. 2 (2): 85–92. doi:10.1007/BF01064374. PMID 10608009. S2CID 28203940.
  2. 1 2 Lippi G, Cervellin G, Franchini M, Favaloro EJ (November 2010). "Biochemical markers for the diagnosis of venous thromboembolism: the past, present and future". J Thromb Thrombolysis. 30 (4): 459–71. doi:10.1007/s11239-010-0460-x. PMID 20213258. S2CID 23806848.
  3. 1 2 Davies RS, Abdelhamid M, Wall ML, Vohra RK, Bradbury AW, Adam DJ (September 2011). "Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm". J Vasc Surg. 54 (3): 865–78. doi:10.1016/j.jvs.2011.04.010. PMID 21684711.
  4. ↑ Misra S, Kumar A, Kumar P, Yadav AK, Mohania D, Pandit AK, Prasad K, Vibha D (September 2017). "Blood-based protein biomarkers for stroke differentiation: A systematic review". Proteomics Clin Appl. 11 (9–10). doi:10.1002/prca.201700007. PMID 28452132. S2CID 13676815.
  5. 1 2 3 Bremme K, Hamad RR, Berg E, Strandberg K, Stenflo J (October 2012). "The APC-PCI concentration as an early marker of activation of blood coagulation: a study of women on combined oral contraceptives". Thromb Res. 130 (4): 636–9. doi:10.1016/j.thromres.2011.11.006. PMID 22154243.



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