Group B streptococcal infection

Group B Streptococcal infection
Other names: Group B streptococcal disease
Streptococcus agalactiae- Gram stain

Group B streptococcal infection, also known as Group B strep (GBS), is an infection caused by the bacteria Streptococcus agalactiae.[1][2] It may result in cellulitis, sepsis and meningitis, particularly in newborns.[1]

GBS infection can cause serious illness and sometimes death, especially in newborns, the elderly, and people with compromised immune systems.[3]

As other virulent bacteria, GBS harbours an important number of virulence factors,[4][5] The most important are the capsular polysaccharide (rich in sialic acid), and a pore-forming toxin, β-haemolysin.[5][6][7] The GBS capsule is probably the key virulence factor because it helps GBS escape from the host defence mechanisms interfering with phagocytic killing of GBS by human phagocytes.[6][8] The GBS β-haemolysin is considered almost identical to the GBS pigment (granadaene).[9][10][11][12][13]

GBS was recognized as a pathogen in cattle by Edmond Nocard and Mollereau in the late 1880s. It can cause bovine mastitis (inflammation of the udder) in dairy cows. The species name "agalactiae" meaning "no milk", alludes to this.[14]

Its significance as a human pathogen was first described in 1938, when Fry reported three fatal cases of puerperal infections caused by GBS.[15] In the early 1960s, GBS was recognized as a main cause of infections in newborns.[16]

In general, GBS is a harmless commensal bacterium being part of the human microbiota colonizing the gastrointestinal and genitourinary tracts of up to 30% of healthy human adults (asymptomatic carriers).[8][17][18]

Laboratory identification

β-haemolytic colonies of Streptococcus agalactiae, blood agar 18h at 36 °C
Positive CAMP test indicated by the formation of an arrowhead where S. agalactiae meets Staphylococcus aureus (white middle streak)
Red colonies of S. agalactiae in granada agar, vagino-rectal culture 18h incubation 36 °C anaerobiosis

As mentioned, S. agalactiae is a Gram-positive coccus with a tendency to form chains, beta-haemolytic, catalase-negative, and facultative anaerobe. GBS grows readily on blood agar plates as microbial colonies surrounded by a narrow zone of β-haemolysis. GBS is characterized by the presence in the cell wall of the group B antigen of the Lancefield classification (Lancefield grouping) that can be detected directly in intact bacteria using latex agglutination tests.[19][20][21]

The CAMP test is also another important test for the identification of GBS. The CAMP factor acts synergistically with the staphylococcal β-haemolysin inducing enhanced haemolysis of sheep or bovine erythrocytes.[19] GBS is also able to hydrolyse hippurate, and this test can also be used to identify GBS.

Haemolytic GBS strains produce an orange-brick-red nonisoprenoid polyene pigment (ornythinrhamnododecaene) (granadaene) when cultivated on granada medium that allows its straightforward identification.[22]

Identification of GBS could also be carried out easily using modern methods as matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry.[23][24] and Nucleic Acid Amplification Techniques (NAATs).[20]

Additionally GBS colonies can be tentatively identified after their appearance in chromogenic agar media.[20][25][26] Nevertheless, GBS-like colonies that develop in chromogenic media should be confirmed as GBS using additional reliable tests (e.g.latex agglutination or the CAMP test) to avoid potential mis-identification.[20][21]

A summary of the laboratory techniques for GBS identification is depicted in Ref 18.[20]

Colonization versus infection

GBS is found in the gastrointestinal and genitourinary tract of humans and is normal component of the intestinal and vaginal microbiota in some women.[17][27] In different studies, GBS vaginal colonization rate ranges from 4 to 36%, with most studies reporting rates over 20%.[28]

Vaginal or rectal colonization may be intermittent, transitory, or persistent.[27] These variations in the reported prevalence of asymptomatic (presenting no symptoms of disease) colonization could be related to the different detection methods used, and differences in populations studied.[29][25][30] Though GBS is an asymptomatic and harmless colonizer of the gastrointestinal human tract in up to 30% of otherwise healthy adults, including pregnant women,[8][29] this opportunistic harmless bacterium can, in some circumstances, cause severe invasive infections.[17]

Pregnancy

Though GBS colonization is asymptomatic and, in general, does not cause problems, it can sometimes cause serious illness for the mother and the baby during gestation and after delivery. GBS infections in the mother can cause chorioamnionitis (intra-amniotic infection or severe infection of the placental tissues) infrequently, postpartum infections (after birth) and it had been related with prematurity and fetal death.[31]

GBS urinary tract infections, more than 100.000 CFU (colony forming units) /mL, may induce labour in pregnant women and cause premature delivery (preterm birth) and miscarriage and requires antibiotic treatment. The presence of GBS in the urine of a pregnant woman, in any colony count, should be considered a marker of heavy GBS colonization and an indication for intra partum antibiotic prophylaxis (IAP).[8][27] [32]

Newborns

In the western world, GBS (in the absence of effective prevention measures) is the main cause of bacterial infections in newborns, such as sepsis, pneumonia, and meningitis, which can lead to death or long-term after effects.[8][33][34]

GBS infections in newborns are separated into two clinical types, early-onset disease (GBS-EOD) and late-onset disease (GBS-LOD). GBS-EOD manifests from 0 to 7 living days in the newborn, most of the cases of EOD being apparent within 24 h from birth. GBS-LOD starts between 7 and 90 days after birth.[8][25][27][34]

Roughly 50% of newborns of GBS colonized mothers are also GBS colonized and (without prevention measures) 1-2% of these newborns will develop GBS-EOD.[27][35]

The most common clinical syndromes of GBS-EOD are sepsis without apparent location, pneumonia, and less frequently meningitis. Bacteremia without a focus occurs in 80-85%, pneumonia in 10-15%, and meningitis in 5-10% of cases. The initial clinical findings are respiratory signs in more than 80% of cases. Neonates with meningitis often have an initial clinical presentation identical to presentation in those without meningeal affectation. An exam of the cerebrospinal fluid is often necessary to rule out meningitis.[8][34][36][37]

Colonization with GBS during labour is the primary risk factor for the development of GBS-EOD. GBS-EOD is acquired vertically (vertical transmission), through exposure of the fetus or the baby to GBS from the vagina of a colonized woman, either in utero (because of ascending infection) or during birth, after rupture of membranes. Infants can also be infected during passage through the birth canal; however, newborns who acquire GBS through this route can only become colonized, and these colonized infants usually do not develop GBS-EOD.[27][38]

Though maternal GBS colonization is the key determinant for GBS-EOD, other factors also increase the risk. These factors are:[8][25][27]

  • Onset of labour before 37 weeks of gestation (premature birth)
  • Prolonged rupture of membranes (longer duration of membrane rupture) (≥18 h before delivery)
  • GBS bacteriuria during pregnancy
  • Intrapartum (during childbirth) fever (>38 °C, >100.4 °F)
  • Amniotic infections (chorioamnionitis)
  • Young maternal age
  • Maternal HIV-infection [39]

Nevertheless, most babies who develop GBS-EOD are born to colonized mothers without any of these risk factors.[25]

Heavy GBS vaginal colonization may be associated with a higher risk for GBS-EOD. Women who had one of these risk factors but who are not GBS colonized at labour are at low risk for GBS-EOD compared to women who were colonized prenatally, but had none of the aforementioned risk factors.[35]

Presence of low levels of anticapsular antibodies against GBS in the mother are also of great importance for the development of GBS-EOD.[40][41]

Because of that, a previous sibling with GBS-EOD is also an important risk factor for the development of the infection in subsequent deliveries, probably reflecting the lack of protective antibodies in the mother. [25][34]

Overall, the case fatality rates from GBS-EOD have declined, from 50% observed in studies from the 1970s to between 2 and 10% in recent years, mainly as a consequence of improvements in therapy and management. Fatal neonatal infections by GBS are more frequent among premature infants.[8][25][42] Today, the mortality associated with GBS EOD in the US is 2.1% among term newborns and 19.2% among preterm newborns.[34][43] GBS-LOD affects infants from 7 days to 3 months of age and has a lower case fatality rate (1%-6%) than GBS-EOD. Clinical syndromes of GBS-LOD are bacteremia without a focus (65%), meningitis (25%), cellulitis, osteoarthritis, and pneumonia. Prematurity has been reported to be the main risk factor. Each week of decreasing gestation increases the risk by a factor of 1.34 for developing GBS-LOD. [44]

GBS-LOD can not only be acquired through vertical transmission during delivery; it can also be acquired later from the mother from breast milk or from environmental and community sources. GBS-LOD commonly shows nonspecific signs, and diagnosis should be made obtaining blood cultures in febrile newborns. S.agalactiae neonatal meningitis does not present with the hallmark sign of adult meningitis, a stiff neck; rather, it presents with nonspecific symptoms, such as fever, vomiting and irritability, and can consequently lead to a late diagnosis. Hearing loss and mental impairment can be a long-term consequence of GBS meningitis.[8][33]

In contrast with GBS-EOD, the incidence of GBS-LOD has remained stable in the US at 0.31 per 1000 live births from 2006 to 2015.[43]

Prevention of neonatal infection

Currently, the only reliable way to prevent GBS-EOD is administration of intrapartum antibiotics before delivery, that is to say, intrapartum antibiotic prophylaxis (IAP). IAP interrupts vertical transmission of GBS from the mother to the newborn and decreases the incidence of GBS-EOD.[45]

Administration of intravenous (IV) antibiotics during labour. Intravenous penicillin or ampicillin given at the onset of labour and then again every four hours until delivery to GBS colonized women have been proven to be very effective at preventing vertical transmission of GBS from mother to baby and GBS-EOD (penicillin G, 5 million units IV initial dose, then 3 million units[27] every 4 hours until delivery or ampicillin, 2 g IV initial dose, then 1 g IV every 4 hours until delivery).[8][25][27]

Penicillin-allergic women without a history of anaphylaxis (angioedema, respiratory distress, or urticaria) following administration of a penicillin or a cephalosporin (low risk of anaphylaxis) could receive cefazolin (2 g IV initial dose, then 1 g IV every 8 hours until delivery) instead of penicillin or ampicillin.[25] If the woman has a severe allergy to beta-lactams then intravenous vancomycin (1 g every 12 hours) is recommended.[46] Neither Clindamycin nor Erythromycin are recommended today because the high proportion of GBS resistance to erythromycin (up to 44.8%),[25][27] Testing for penicillin allergy and can be helpful for all GBS carrying pregnant women and will cancel the frequent use of other antibiotics for GBS-EOD IAP.[27] Neither oral nor intramuscular antibiotics are effective in reducing the risk GBS-EOD.[27]

Antibiotic susceptibility testing of GBS isolates is crucial for appropriate antibiotic selection for IAP in penicillin-allergic women, because resistance to clindamycin, the most common agent used (in penicillin-allergic women), is increasing among GBS isolates. Appropriate methodologies (including inducible clindamycin resistance) for testing are important, because resistance to clyndamicin (antimicrobial resistance) can occur in some GBS strains that appear susceptible (antibiotic sensitivity) in certain susceptibility tests.[21][25]

For women who are at risk of anaphylaxis after exposure to penicillin, the laboratory requisitions should indicate clearly the presence of penicillin allergy to ensure that the laboratory is aware for the need of testing GBS isolates for clindamycin susceptibility. Vancomycin (20 mg/Kg every 8 hours until delivery)[27] is used to prevent GBS-EOD in infants born to penicillin-allergic mothers.[25][27]

If appropriate IAP in GBS colonized women starts as soon as possible once labour starts or waters have broken. When the first dose is given at least 4 hours before delivery, the risk of neonatal infection is reduced; when given between 2–4 hours before delivery the risk is partially reduced.[47][48][49]

True penicillin allergy is rare with an estimated frequency of anaphylaxis of one to five episodes per 10,000 cases of penicillin therapy.[50][51] Penicillin administered to a woman with no history of β-lactam allergy has a risk of anaphylaxis of 0.04 to 4 per 100,000. Maternal anaphylaxis associated with GBS IAP occurs, but any morbidity associated with anaphylaxis is offset greatly by reductions in the incidence of GBS-EOD. [25]

IAPs have been considered to be associated with the emergence of resistant bacterial strains and with an increase in the incidence of early-onset infections caused by other pathogens, mainly Gram-negative bacteria such as Escherichia coli. Nevertheless, most studies have not found an increased rate of non-GBS early-onset sepsis related to the widespread use of IAP. [25][52][53][54]

Other strategies to prevent GBS-EOD have been studied, and chlorhexidine intrapartum vaginal cleansing has been proposed to help preventing GBS-EOD, nevertheless no evidence has been shown for the effectiveness of this approach.[25][27][55][56]

Identifying candidates to receive IAP

Two ways are used to select female candidates to IAP: the culture-based screening approach and the risk-based approach.[57] The culture-based screening approach identifies candidates using lower vaginal and rectal cultures obtained between 35 and 37 weeks of gestation (or 36-37[27]), and IAP is administered to all GBS colonized women. The risk-based strategy identifies candidates to receive IAP by the aforementioned risk factors known to increase the probability of GBS-EOD without considering if the mother is or is not a GBS carrier.[8][25][58]

IAP is also recommended for women with intrapartum risk factors if their GBS carrier status is not known at the time of delivery, and for women with GBS bacteriuria (in any colony count) during their pregnancy, and for women who have had an infant with GBS-EOD previously. The risk-based approach is, in general, less effective than the culture-based approach,[59] because in most cases, GBS-EOD develops among newborns who have been born to mothers without risk factors.[25][35][60]

IAP is not required for women undergoing planned caesarean section in the absence of labour and with intact membranes, irrespective of the known GBS carriage status.[25][27]

Routine screening of pregnant women is performed in most developed countries such as the United States, France, Spain, Belgium, Canada, and Australia, and data have shown falling incidences of GBS-EOD following the introduction of screening-based measures to prevent GBS-EOD.[30][60] [61]

The risk-based strategy is advocated, among other counties, in the United Kingdom, the Netherlands, New Zealand, and Argentina.[30]

The issue of cost-effectiveness of both strategies for identifying candidates for IAP is less clear-cut, and some studies have indicated that testing low risk women, plus IAP administered to high-risk women, and to those found to carry GBS is more cost-effective than the current UK practice.[62] Other evaluations have also found the culture-based approach to be more cost-effective than the risk-based approach for the prevention of GBS-EOD.[63][64]

Testing pregnant women to detect GBS carriers and giving IAP to those carrying GBS and to high-risk women has also been proposed and this approach is significantly more cost-effective than the use of the risk-factor approach. One research paper calculated an expected net benefit to the UK government of such an approach of around £37 million a year, compared with the current RCOG approach.[62][63]

It has been reported that IAP does to not prevent all cases of GBS-EOD; its efficacy is estimated at 80%. The risk-based prevention strategy does not prevent about 33% of cases with no risk factors.[65]

Up to 90% of cases of GBS-EOD would be preventable if IAP were offered to all GBS carriers identified by universal screening late in pregnancy, plus to the mothers in higher risk situations.[66]

Where insufficient intravenous antibiotics are given before delivery, the baby may be given antibiotics immediately after birth, although evidence is inconclusive as to whether this practice is effective or not.[25][67][68][69]

Falling incidence of EOD and LOD GBS disease in US-CDC

Home births and water birth

Home births are becoming increasingly popular in the UK. Recommendations for preventing GBS infections in newborns are the same for home births as for hospital births. Around 25% of women having home births probably carry GBS in their vaginas at delivery without knowing, and it could be difficult to follow correctly the recommendations of IAP and to deal with the risk of a severe allergic reaction to the antibiotics outside of a hospital setting.[70]

The RCOG and the ACOG guidelines suggest that birth in a pool is not contraindicated for GBS carriers who have been offered the appropriate IAP if no other contraindications to water immersion are present[27][71]

Screening for colonization

Approximately 10–30% of women are colonized with GBS during pregnancy. Nevertheless, during pregnancy, colonization can be temporary, intermittent, or continual.[25] Because the GBS colonization status of women can change during pregnancy, only cultures carried out ≤5 weeks before delivery predict quite accurately the GBS carrier status at delivery.[72] In contrast, if the prenatal culture is carried out more than 5 weeks before delivery, it is unreliable for accurately predicting the GBS carrier status at delivery. Because of that, testing for GBS colonization in pregnant women is recommended by the CDC at 36–37 weeks of gestation.[25][73]

It is important to note that the ACOG now recommends performing universal GBS screening between 36 and 37 weeks of gestation. This new recommendation provides a 5-week window for valid culture results that includes births that occur up to a gestational age of at least 41 weeks.[27]

The clinical samples recommended for culture of GBS are swabs collected from the lower vagina and rectum through the external anal sphincter.Vaginal-rectal samples should be collected using a flocked swab preferably. Compared with fiber swab, these swabs releases samples and microorganisms more efficiently than conventional fiber swabs.[21]

The sample should be collected swabbing the lower vagina (vaginal introitus) followed by the rectum (i.e., inserting the swab through the anal sphincter) using the same swab or two different swabs. Cervical, perianal, perirectal, or perineal specimens are not acceptable, and a speculum should not be used for sample collection.[25] Samples can be taken by healthcare professionals, or by the mother herself with appropriate instruction.[74][75][76]

Instructions for the collection of a genital swab for the detection of GBS

Following the recommendations of the CDC, these swabs should be placed into a non-nutritive transport medium. When feasible, specimens should be refrigerated and sent to the laboratory as soon as possible.[21][25] Appropriate transport systems are commercially available, and in these transport media, GBS can remain viable for several days at room temperature. However, the recovery of GBS declines over one to four days, especially at elevated temperatures, which can lead to false-negative results.[21][25][77]

Culture methods

Samples (vaginal, rectal, or vaginorectal swabs) should be inoculated into a selective enrichment broth, (Todd Hewitt broth with selective antibiotics, enrichment culture). This involves growing the samples in a selective enriched broth medium to improve the viability of the GBS and simultaneously impairing the growth of other naturally occurring bacteria.Appropriate enrichment broths, commercially available, are Todd-Hewitt with gentamicin and nalidixic acid, or with colistin and nalidixic acid (Lim broth).[21]

After incubation (18–24 hours, 35-37 °C), the enrichment broth is subcultured overnight in blood agar plates and GBS-like colonies (big colonies, 3-4 millimeters diameter, surrounded by narrow zone of hemolysis) [20][21] are identified by the CAMP test or using latex agglutination with GBS antiserum or MALDI-TOF.[21][25][27]

In the UK, this is the method described by the Public Health England's UK Standards for Microbiology Investigations[78] After incubation, the enrichment broth can also be subcultured to granada medium agar where GBS grows as pinkish-red colonies [20][22][79] [80] or to chromogenic agars, where GBS grows as coloured colonies.[25] Nevertheless, GBS-like colonies that develop in chromogenic media should be confirmed as GBS using additional reliable tests to avoid mis-identification.[20]

Inoculating directly the vaginal and rectal swabs or the vaginorectal swab in a plate of an appropriate culture medium (blood agar, granada medium or chromogenic media) is also possible. However, this method (bypassing the selective enrichment broth step) can lead to some false-negative results, and this approach should be taken only in addition to, and not instead of, inoculation into selective broth.[25]

Today, in the UK, the detection of GBS colonization using the enrichment broth technique is not offered from most laboratories serving the NHS. However, the implementation of this test seems to be a viable option. At present, culture for GBS (using enriched culture medium) at 35–37 weeks to define an at-risk group of women appears to be the most cost-effective strategy.[63][64]

The charitable organization Group B Strep Support have published a list of hospitals in the UK that offer the detection of GBS using the enrichment broth culture method (enrichment culture medium, ECM).[81] This test is also available privately from around £35 per test for a home-testing pack, and it is offered by private clinics.[81] The test is also available privately, for a UK-wide postal service.[82][83]

Point-of-care testing, POCT

No current culture-based test is both accurate enough and fast enough to be recommended for detecting GBS once labour starts. Plating of swab samples requires time for the bacteria to grow, meaning that this is unsuitable to be used as an intrapartum point-of-care test (POCT or bedside testing).[27]

Alternative methods to detect GBS in clinical samples (as vaginorectal swabs) rapidly have been developed, such are the methods based on nucleic acid amplification tests, such as polymerase chain reaction (PCR) tests, and DNA hybridization probes. These tests can also be used to detect GBS directly from broth media, after the enrichment step, avoiding the subculture of the incubated enrichment broth to an appropriate agar plate.[20][25][84]

Testing women for GBS colonization using vaginal or rectal swabs at 35–37 weeks of gestation and culturing them in an enriched media is not as rapid as a PCR test that would check whether the pregnant woman is carrying GBS at delivery. PCR tests would allow starting IAP on admission to the labour ward in those women for whom it is not known if they are GBS carriers.[25] PCR testing for GBS carriage could, in the future, be sufficiently accurate to guide IAP. However, the PCR technology to detect GBS must be improved and simplified to make the method cost-effective and fully useful as a point-of-care test. These tests still cannot replace antenatal culture for the accurate detection of GBS.[25][27][85] POCT for detection of GBS carriers requires additionally that maternity units should provide 24/7 laboratory means required to perform rapid testing. Nevertheless, point-of-care testing may be used for women who present in labor with an unknown GBS status and without risk factors for ascertaining the use of IAP.[27]

Missed opportunities of prevention

The important factors for successful prevention of GBS-EOD using IAP and the universal screening approach are:

  • Reach most pregnant women for antenatal screens
  • Proper sample collection
  • Using an appropriate procedure for detecting GBS
  • Administering a correct IAP to GBS carriers

Most cases of GBS-EOD occur in term infants born to mothers who screened negative for GBS colonization and in preterm infants born to mothers who were not screened, though some false-negative results observed in the GBS screening tests can be due to the test limitations and to the acquisition of GBS between the time of screening and delivery. These data show that improvements in specimen collection and processing methods for detecting GBS are still necessary in some settings. False-negative screening test, along with failure to receive IAP in women delivering preterm with unknown GBS colonization status, and the administration of inappropriate IAP agents to penicillin-allergic women account for most missed opportunities for prevention of cases of GBS-EOD.[86]

GBS-EOD infections presented in infants whose mothers had been screened as GBS culture-negative are particularly worrying, and may be caused by incorrect sample collection, delay in processing the samples, incorrect laboratory techniques, recent antibiotic use, or GBS colonization after the screening was carried out.[60][86][87][88][89]

Epidemiology

In 2000–2001, the reported overall incidence of GBS infection in newborn babies in the UK was 0.72 per 1,000 live births, 0.47 per 1,000 for GBS-EOD and 0.25 per 1,000 for GBS-LOD. Very marked variations were observed, the incidence in Scotland was 0.42 per 1,000, whilst in Northern Ireland, it was 0.9 per 1,000 live births. [90][91]

Nevertheless, it may be a serious underestimation of the real incidence of GBS infections in newborns. A plausible explanation of this is that a considerable number of infants with probable GBS-EOD had negative cultures as a result of a previous maternal antibiotic treatment that inhibits the growth of GBS in blood and cerebrospinal fluid cultures, but does not mask clinical symptoms.[92][93] Data collected prospectively for neonates that required a septic screen in the first 72 hrs of life in the UK, indicated a combined rate of definite and probable GBS-EOD infection of 3.6 per 1,000 live births.[94] Another study on the epidemiology of invasive GBS infections in England and Wales, reported a rise in the incidence of GBS-EOD between 2000 and 2010 from 0.28 to 0.41 per 1,000 live births. Rates of GBS-LOD also increased between 1991 and 2010 from 0.11 to 0.29 per 1,000 live births in England and Wales.[95]

In the past, the incidence of GBS-EOD ranged from 0.7 to 3.7 per thousand live births in the US,[8] and from 0.2 to 3.25 per thousand in Europe.[30] In 2008, after widespread use of antenatal screening and intrapartum antibiotic prophylaxis, the Centers for Disease Control and Prevention in the United States reported an incidence of 0.28 cases of GBS-EOD per thousand live births in the US.[96] From 2006 to 2015 the incidence of GBS EOD decreased to 0.37 to 0.23 per thousand live births in the US.[43] In contrast, the incidence of GBS-LOD has remained unchanged at 0.26-0.31 per 1,000 live births in the US.[43][97]

Falling incidence of GBS-EOD in Spain (Castrillo Group of Hospitals)

In Spain, the incidence of GBS vertical sepsis declined by 73.6%, from 1.25/1,000 live births in 1996 to 0.33/1,000 in 2008.[98] The "Grupo de Hospitales Fundación Castrillo"[99] has also reported in 2018 an incidence of GBS EOD of 0.17/1000 live births and 0,05/1000 GBS LOD. In the Barcelona area between 2004 and 2010, the incidence of GBS-EOD was 0.29 per thousand living newborns, with no significant differences along the years. The mortality rate was 8.16%.[60][100]

In France since 2001, a rapid decrease in the incidence of the neonatal GBS infections has also been reported after widespread use of IAP, from 0.7 to 0.2 per 1,000 births between 1997 and 2006.[101]

Since 2012 the incidence of neonatal GBS infection has been estimated as 0.53 per 1,000 births in the European region, 0.67 in America, and 0.15 in Australasia. Countries reporting no use of IAP had a 2.2-fold higher incidence of GBS-EOD compared with those reporting any use of IAP.[42][91] Estimates of the incidence of GBS EOD per 1,000 births differs among countries, Japan 0.09, Panama 0,58, Hong Kong 0,76, and 2.35 in the Dominican Republic. Overall, rates are highest in Africa and lowest in Asia. The estimate of the global incidence of GBS LOD is 0.26 cases per 1,000 live births.[102]

It has been appraised that GBS infections cause at least 409.000 maternal/fetal/infant cases and 147.000 stillbirths and infant deaths worldwide annually.[103]

The following are estimates of the chances that a baby will be infected with a GBS neonatal infection if no preventive measures are taken and no other risk factors are present:[104]

  • One in 1,000 where the woman is not a known GBS carrier
  • One in 400 where the woman carries GBS during the pregnancy
  • One in 300 where the woman carries GBS at delivery
  • One in 100 where the woman had a previous baby infected with GBS

If a woman who carries GBS is given IAP during labour, the baby's risk is reduced significantly:

  • One in 8,000 where the mother carries GBS during pregnancy;
  • One in 6,000 where the mother carries GBS at delivery; and
  • One in 2,200 where the mother has previously had a baby infected with GBS

Guidelines

United Kingdom

Royal College of Obstetricians and Gynaecologists (RCOG)

The Royal College of Obstetricians and Gynaecologists (RCOG) first issued their Green Top Guideline No 36 "Prevention of early onset neonatal Group B streptococcal disease" in 2003.[105] This guideline clearly stated: "Routine bacteriological screening of all pregnant women for antenatal GBS carriage is not recommended, and vaginal swabs should not be taken during pregnancy unless there is a clinical indication to do so." But, "Intrapartum antibiotic prophylaxis should be offered if GBS is detected on a vaginal swab in the current pregnancy."

Nevertheless, this guideline uses minimum incidence figures from a study undertaken in 2000–2001,[106] so it could not only have underestimated the true incidence of GBS infection, but it could also have underestimated the risks to babies from GBS infection. GBS infection in babies has increased in England, Wales, and Northern Ireland since 2003 (when the guideline was introduced). Voluntarily reported cases from the Communicable Disease Report/Health Protection Agency show 0.48 cases per 1,000 live births in 2003, and this figure increased to 0.64 per 1,000 in 2009.[107]

In 2007, the RCOG published the findings of their audit to evaluate practice in the UK obstetric units against their recommendations.[108]

The audit started out by comparing international guidelines for prevention of GBS-EOD: highlighting the fact that, in contrast to the UK and New Zealand guidelines, most of the other countries recommended identifying women for IAP by offering effective tests to all pregnant women. The audit reviewed hospitals' protocols against GBS infection in newborns. Of the 161 UK units, which submitted their protocol, four units did not even have a protocol for GBS, of those that did, 35% did not mention the 2003 RCOG guideline, and only a minority of units had protocols entirely consistent with the guideline.

Further UK research published in 2010 looked at the opportunities for prevention of GBS-EOD following the introduction of the RCOG guideline. They found that, in the 48 cases of GBS during 2004 to 2007 (0.52/1,000 live births), only 19% of the mothers in whom risk factors were present were given adequate IAP. The researchers stated: "if all women with risk factors received prophylaxis, 23 cases (48%) may have been prevented."[65]

The 2003 RCOG guideline was reviewed in July 2012 and again in September 2017 with substantial changes.[46]

The second and final audit report into GBS (Audit of current practice in preventing GBS EOD in the UK) has been published. As a result of the audit, the RCOG have recommended that the national guidelines for preventing GBS infection in newborns should be updated.[109]

In the UK, the RCOG still does not recommend bacteriological screening of all pregnant women for antenatal GBS carriage in its 2017 guidelines, although it does state that women who tested positive in a previous pregnancy and the baby was well should be offered the option of testing and being offered intrapartum antimicrobial prophylaxis or having the IAP without testing[71] Nevertheless, it is stated that if GBS carriage is detected incidentally or by intentional testing, women should be offered IAP. And that all pregnant women should be provided with an appropriate information leaflet about GBS and pregnancy (published in December 2017).[110] Instead, women are treated according to their risk in labour. IAP is offered to women in labout where GBS has been found from their urine or vaginal/rectal swabs taken during the pregnancy, and to women who have previously had a baby with GBS disease. Immediate induction of labour and IAP should be offered to all women with prelabour rupture of membranes at 37 weeks of gestation or more, to women whose membranes are ruptured more than 18 hours and to those who have fever in labour.

Women who are pyrexial in labour should be offered broad-spectrum antibiotics including an antibiotic appropriate for preventing EOD-GBS.[71]

NICE guidelines

The UK's National Institute for Health and Care Excellence (NICE) does not recommend routine testing for GBS, stating: "Pregnant women should not be offered routine antenatal screening for group B streptococcus because evidence of its clinical and cost effectiveness remains uncertain."[111] However, the guideline states that "At the first antenatal (booking) appointment (and later if appropriate), discuss and give information on .... infections that can impact on the baby in pregnancy or during birth (such as group B streptococcus, herpes simplex and cytomegalovirus)"[112]

Nevertheless, the NICE Neonatal Infection guideline states: "Offer antibiotics during labour to women who:

  • are in pre-term labour or
  • have group B streptococcal colonisation, bacteriuria or infection during the current pregnancy or
  • have had group B streptococcal colonisation, bacteriuria or infection in a previous pregnancy, and have not had a negative test for group B streptococcus by enrichment culture or PCR on a rectovaginal swab samples collected between 35 and 37 weeks' gestation or 3-5 weeks before the anticipated delivery date in the current pregnancy or
  • have had a previous baby with an invasive group B streptococcal infection or
  • have a clinical diagnosis of chorioamnionitis. [2021]".[113]
National Screening Committee

The UK National Screening Committee's current policy position on GBS is: "screening should not be offered to all pregnant women. This policy was reviewed in 2012, and despite receiving 212 responses, of which 93% advocated screening, the NSC has decided to not recommend antenatal screening.[114]

This decision was strongly criticized by the charity Group B Strep Support as ignoring both the wishes of the public and the rising incidence rates of GBS infection in the UK.[115]

United States

Recommendations for IAP to prevent perinatal GBS disease were issued in 1996 by the CDC. In these guidelines, the use of one of two prevention methods was recommended: either a risk-based approach or a culture-based screening approach.[57] The CDC issued updated guidelines in 2002; these guidelines recommended the universal culture-based screening of all pregnant women at 35–37 weeks' gestation to optimize the identification of women who must receive IAP. CDC also recommended that women with unknown GBS colonization status at the time of delivery be managed according to the presence of intrapartum risk factors. Because of this strategy, the US has seen a major reduction in the incidence of GBS-EOD.[116]

The CDC issued updated guidelines again in 2010, however, the foundations of prevention in the CDC's 2010 guidelines remained unchanged.[25] The following were the main additions in the 2010 guidelines:

  • Expanded options for laboratory detection of GBS include the use of pigmented media and PCR assays.
  • A revised colony count threshold was set for laboratories to report GBS in the urine of pregnant women.
  • Revised algorithms for GBS screening and use of IAP for women with threatened preterm delivery include one algorithm for preterm labor and one for preterm premature rupture of membranes.
  • Recommendations for IAP agents are presented in an algorithm format in an effort to promote the use of the most appropriate antibiotic for penicillin-allergic women.
  • A minor change has been made to penicillin dosing to facilitate implementation in facilities with different packaged penicillin products.
  • The neonatal management algorithm's scope was expanded to apply to all newborns.
  • Management recommendations depend upon clinical appearance of the neonate and other risk factors such as maternal chorioamnionitis, adequacy of IAP if indicated for the mother, gestational age, and duration of membrane rupture.
  • Changes were made to the algorithm to reduce unnecessary evaluations in well-appearing newborns at relatively low risk for GBS-EOD.

In 2018, the task of revising and updating the GBS prophylaxis guidelines were transferred from the CDC to ACOG, to the American Academy of Pediatrics, AAP and to the American Society for Microbiology, ASM.[27][117]

The ACOG committee issued an updated document on Prevention of Group B Streptococcal Early-Onset Disease in Newborns in 2019.[27] ACOG's guidance replaced the 2010 guidelines published by CDC.

This document does not introduce important changes from the CDC guidelines. The key measures necessary for preventing neonatal GBS early onset disease continue to be universal prenatal screening by culture of GBS from swabs collected from the lower vagina and rectum, correct collection and microbiological processing of the samples, and proper implementation of intrapartum antibiotic prophylaxis. It is also important to note that the ACOG recommended performing universal GBS screening between 36 and 37 weeks of gestation. This new recommendation provides a 5-week window[72] for valid culture results that includes births that occur up to a gestational age of at least 41 weeks.

In 2019, American Academy of Pediatrics (AAP) published a new clinical report—Management of Infants at Risk for GBS neonatal disease.[34] This AAP's Clinical Report replaces the 2010 guidelines published by CDC.

Following the CDC commission the American Society for Microbiology (ASM) published in 2020 Guidelines for the Detection and Identification of Group B Streptococcus.[21][118] In this guidelines it is said that "laboratory practices for GBS screening have not changed substantially since 2010" and culture is still the main technique for GBS detection and direct detection of GBS from vagino-rectal samples using NAATs is not recommended.

Other guidelines

National guidelines in most developed countries advocate the use of universal screening of pregnant women late in pregnancy to detect GBS carriage and use of IAP in all colonized mothers. e.g. Canada,[119] Spain,[120] Switzerland,[121] Germany,[122] Poland,[123] Czech Republic,[124] France,[125] and Belgium.[126]

In contrast, risk factor-based guidelines were issued (in addition to the UK) in the Netherlands,[127]

The Royal Australian and New Zealand College of Obstetricians and Gynaecologists does not recommend clearly one of both prevention strategies -either the risk-based or the culture-based approach to identify pregnant women for IAP, and allow practitioners to choose according jurisdictional guidelines.[128]

Adults

GBS is also an important infectious agent able to cause invasive infections in adults. Serious life-threatening invasive GBS infections are increasingly recognized in the elderly and in individuals compromised by underlying diseases such as diabetes, cirrhosis and cancer.[102][129] GBS infections in adults include urinary tract infection, skin and soft-tissue infection (skin and skin structure infection) bacteremia without focus, osteomyelitis, meningitis and endocarditis.[17] GBS infection in adults can be serious, and mortality is higher among adults than among neonates.[102]

In general, penicillin is the antibiotic of choice for treatment of GBS infections. Erythromycin or clindamycin should not be used for treatment in penicillin-allergic patients unless susceptibility of the infecting GBS isolate to these agents is documented. Gentamicin plus penicillin (for antibiotic synergy) in patients with life-threatening GBS infections may be used.[129][130][131]

Invasive GBS infections in non-pregnant adults convey a rising hardship in most developed countries. Vaccination to prevent GBS infection could be a crucial approach to prevent GBS disease in adults.[132][133]

Toxic shock syndrome (TSS) is an acute multisystem life-threatening disease resulting in multiple organ failure. The severity of this disease frequently warrants immediate medical treatment. TSS is caused primarily by some strains of Staphylococcus aureus and Streptococcus pyogenes that produce exotoxins. Nevertheless, invasive GBS infection can be complicated, though quite infrequently, by streptococcal toxic shock-like syndrome (STLS)[134]

Society and culture

July has been recognised as Group B Strep Awareness Month,[135] a time when information about group B Strep aimed at families and health professionals is shared, predominantly in the UK and the US. In the UK, this is led by Group B Strep Support[136]

Vaccine

Though the introduction of national guidelines to screen pregnant women for GBS carriage and the use of IAP has significantly reduced the burden of GBS-EOD disease, it has had no effect on preventing either GBS-LOD in infants or GBS infections in adults.[137] Because of this, if an effective vaccine against GBS were available, it would be an effective means of controlling not only GBS disease in infants, but also infections in adults.[133]

There are a number of problems with giving antibiotics to women in labor. Such antibiotic exposure risks included severe allergic reactions and difficulties screening pregnant women for GBS. If pregnant women could be given a vaccine against GBS, this could potentially prevent most cases of GBS without the need for antibiotics or screening. Vaccination is considered an ideal solution to prevent not only early- and late-onset disease but also GBS infections in adults at risk.[138]

Development of GBS vaccines for maternal immunization has been identified as a priority by the World Health Organization on the basis of high unmet need.[139] It has been estimated that such a vaccine could potentially prevent 231,000 infant and maternal GBS cases.[140]

As early as 1976,[40] low levels of maternal antibodies against the GBS capsular polysaccharide were shown to be correlated with susceptibility to GBS-EOD and GBS-LOD. Maternal-specific antibodies, transferred from the mother to the newborn, were able to confer protection to babies against GBS infection.[141]

The capsular polysaccharide of GBS, which is an important virulence factor, is also an excellent candidate for the development of an effective vaccine.[141][142][143][144]

GBS protein-based vaccines are also in development and are greatly promising as they will be able to protect against GBS infection of any serotype.[133][145][146][147][148]

At present, the licensing of GBS vaccines is difficult because of the challenge in conducting clinical trials in humans due to the low incidence of GBS neonatal diseases.[30][143][149]

Nevertheless, though research and clinical trials for the development of an effective vaccine to prevent GBS infections are underway, no vaccine is available as of 2021.[145][148][150]

Nonhuman infections

GBS has been found in many mammals and other animals such as camels, dogs, cats, seals, dolphins, and crocodiles.[151]

Cattle

In cattle, GBS causes mastitis, an infection of the udder. It can produce an acute febrile disease or a subacute, more chronic disease. Both lead to diminishing milk production (hence its name: agalactiae meaning "no milk"). Mastitis associated with GBS can have an important effect on the quantity and quality of milk produced, and is also associated with elevated somatic cell count and total bacteria count in the milk.[152]

Outbreaks in herds are common, and as this is of major significance for the dairy industry, programs to reduce the impact of GBS have been enforced in many countries[153]

Fish

GBS it is also an important pathogen in a diversity of fish species, leading to serious economic losses in many species of fish worldwide. GBS causes severe epidemics in farmed fish, causing sepsis and external and internal hemorrhages. GBS infection has been reported from wild and captive fish and has been involved in epizootics in many countries.[154][155] Vaccines to protect fish against GBS infections are under development.[156][157]

References

  1. 1 2 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "14. Bacterial infections". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 263. ISBN 978-0-323-54753-6. Archived from the original on 13 December 2022. Retrieved 13 December 2022.
  2. ↑ "Group B strep". nhs.uk. March 2021. Archived from the original on 27 May 2021. Retrieved 13 December 2022.
  3. ↑ Healy, Brendan (18 November 2022). "Group B streptococcal infection - Symptoms, diagnosis and treatment | BMJ Best Practice". bestpractice.bmj.com. Archived from the original on 13 August 2022. Retrieved 13 December 2022.
  4. ↑ Maisey HC, Doran KS, Nizet V (2009). "Recent advances in understanding the molecular basis of group B Streptococcus virulence". Expert Reviews in Molecular Medicine. 10: e27. doi:10.1017/S1462399408000811. PMC 2676346. PMID 18803886.
  5. 1 2 B Armistead, E Oler, K Adams Waldorf, L Rajagopal (2019). "The double life of Group B Streptococcus: Asymptomatic colonizer and potent pathogen". Journal of Molecular Biology. 43 (16): 2914–2931. doi:10.1016/j.jmb.2019.01.035. PMC 6646060. PMID 30711542.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. 1 2 Rajagopal L. (2009). "Understanding the regulation of Group B Streptococcal virulence factors". Future Microbiology. 4 (2): 201–221. doi:10.2217/17460913.4.2.201. PMC 2691590. PMID 19257847.
  7. ↑ Leclercq SY, Sullivan MJ, Ipe DS, Smith JP, Cripps AW, Ulett GC (2016). "Pathogenesis of Streptococcus urinary tract infection depends on bacterial strain and β-hemolysin/cytolysin that mediates cytotoxicity, cytokine synthesis, inflammation and virulence". Scientific Reports. 6: 29000. Bibcode:2016NatSR...629000L. doi:10.1038/srep29000. PMC 4935997. PMID 27383371.
  8. 1 2 3 4 5 6 7 8 9 10 11 12 13 Edwards MS, Nizet V (2011). Group B streptococcal infections. Infectious Diseases of the Fetus and Newborn Infant (7th. ed.). Elsevier. pp. 419–469. ISBN 978-0-443-06839-3.
  9. ↑ Whidbey C, Harrell MI, Burnside K, Ngo L, Becraft AK, Iyer LM, Aravind L, Hitti J, Waldorf KM, Rajagopal L (2013). "A hemolytic pigment of Group B Streptococcus allows bacterial penetration of human placenta". The Journal of Experimental Medicine. 210 (6): 1265–1281. doi:10.1084/jem.20122753. PMC 3674703. PMID 23712433.
  10. ↑ Rosa-Fraile M, Dramsi S, Spellerberg B (2014). "Group B streptococcal haemolysin and pigment, a tale of twins". FEMS Microbiology Reviews. 38 (5): 932–946. doi:10.1111/1574-6976.12071. PMC 4315905. PMID 24617549.
  11. ↑ Whidbey C, Vornhagen J, Gendrin C, Boldenow E, Samson JM, Doering K, Ngo L, Ezekwe EA Jr, Gundlach JH, Elovitz MA, Liggitt D, Duncan JA, Adams Waldorf KM, Rajagopal L (2015). "A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury". EMBO Molecular Medicine. 7 (4): 488–505. doi:10.15252/emmm.201404883. PMC 4403049. PMID 25750210.
  12. ↑ Christopher-Mychael Whidbey (2015). Characterization of the Group B Streptococcus Hemolysin and its Role in Intrauterine Infection (PDF). University of Washington. Archived (PDF) from the original on 12 January 2021. Retrieved 3 October 2022.
  13. ↑ B Armistead, P Quach, J M Snyder, V Santana-Ufret, A Furuta, A Brokaw, Rajagopal (2020). "Hemolytic Membrane Vesicles of Group B Streptococcus Promote Infection". The Journal of Infectious Diseases. 223 (iaa548): 1488–1496. doi:10.1093/infdis/jiaa548. PMC 8064051. PMID 32861213.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  14. ↑ Keefe GP. (1997). "Streptococcus agalactiae mastitis: A review". The Canadian Veterinary Journal. 38 (7): 199–204. PMC 1576741. PMID 9220132.
  15. ↑ Fry RM. (1938). "Fatal infections by haemolytic streptococcus group B.". The Lancet. 231 (5969): 199–201. doi:10.1016/S0140-6736(00)93202-1.
  16. ↑ Eickhoff TC; Klein JO; Kathleen Daly A; David Ingall; Finland M. (1964). "Neonatal Sepsis and Other Infections Due to Group B Beta-Hemolytic Streptococci". New England Journal of Medicine. 271 (24): 1221–1228. doi:10.1056/NEJM196412102712401. PMID 14234266.
  17. 1 2 3 4 Edwards MS, Baker CJ (2010). Streptococcus agalactiae (group B streptococcus). Mandell GL, Bennett JE, Dolin R (eds) Principles and practice of infectious diseases. Vol 2 (7th. ed.). Elsevier. pp. Chapter 202. ISBN 978-0-443-06839-3.
  18. ↑ "Group B Strep Infection". MedicineNet.com. Archived from the original on 17 April 2021. Retrieved 22 February 2021.
  19. 1 2 Tille P. (2014). Bailey & Scott's Diagnostic Microbiology (13th. ed.). Elsevier. ISBN 978-0-323-08330-0.
  20. 1 2 3 4 5 6 7 8 9 Rosa-Fraile M.,Spellerberg B. (2017). "Reliable Detection of Group B Streptococcus in the Clinical Laboratory". Journal of Clinical Microbiology. 55 (9): 2590–2598. doi:10.1128/JCM.00582-17. PMC 5648696. PMID 28659318.
  21. 1 2 3 4 5 6 7 8 9 10 Filkins L, Hauser J, Robinson-Dunn B, Tibbetts R, Boyanton B, Revell P. "Guidelines for the Detection and Identification of Group B Streptococcus March 10, 2020 American Society for Microbiology" (PDF). Archived from the original (PDF) on 27 June 2021. Retrieved 22 February 2021.{{cite web}}: CS1 maint: multiple names: authors list (link)
  22. 1 2 Rosa-Fraile M, Rodriguez-Granger J, Cueto-Lopez M, Sampedro A, Biel Gaye E, Haro M, Andreu A (1999). "Use of Granada medium to detect group B streptococcal colonization in pregnant women". Journal of Clinical Microbiology. 37 (8): 2674–2677. doi:10.1128/JCM.37.8.2674-2677.1999. PMC 85311. PMID 10405420.
  23. ↑ Binghuai L, Yanli S, Shuchen Z, Fengxia Z, Dong L, Yanchao C (2014). "Use of MALDI-TOF mass spectrometry for rapid identification of group B Streptococcus on chromID Strepto B agar". International Journal of Infectious Diseases. 27: 44–48. doi:10.1016/j.ijid.2014.06.023. PMID 25220051. Archived from the original on 13 December 2022. Retrieved 3 October 2022.
  24. ↑ To KN, Cornwell E, Daniel R, Goonesekera S, Jauneikaite E, Chalker V, Le Doare K. (2019). "Evaluation of matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) for the Identification of Group B Streptococcus". BMC Research Notes. 12 (1): 85. doi:10.1186/s13104-019-4119-1. PMC 6376729. PMID 30764872.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  25. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Verani JR, McGee L, Schrag SJ (2010). "Prevention of perinatal group B streptococcal disease: revised guidelines from CDC" (PDF). MMWR Recomm. Rep. 59 ((RR-10)): 1–32. Archived (PDF) from the original on 27 June 2021. Retrieved 3 October 2022.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  26. ↑ El Aila NA, Tency I, Claeys G, Saerens B, Cools P, Verstraelen H, Temmerman M, Verhelst R, Vaneechoutte M (2010). "Comparison of different sampling techniques and of different culture methods for detection of group B streptococcus carriage in pregnant women". BMC Infectious Diseases. 10: 285. doi:10.1186/1471-2334-10-285. PMC 2956727. PMID 20920213.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  27. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 "Prevention of Group B Streptococcal Early-Onset Disease in Newborns ACOG COMMITTEE OPINION Number 797". Obstetrics & Gynecology. 135 (2): e51-72. 2020. doi:10.1097/AOG.0000000000003668. PMID 31977795. S2CID 210891255. Archived from the original on 20 January 2021. Retrieved 22 February 2021.
  28. ↑ Russell NJ, Seale AC, O'Driscoll M, O'Sullivan C, Bianchi-Jassir F, Gonzalez-Guarin J, Lawn JE, Baker CJ, Bartlett L, Cutland C, Gravett MG, Heath PT, Le Doare K, Madhi SA, Rubens CE, Schrag S, Sobanjo-Ter Meulen A, Vekemans J, Saha SK, Ip M (2017). "Maternal Colonization With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses". Clinical Infectious Diseases. 65 (Suppl 2) (Suppl 2): S100-111. doi:10.1093/cid/cix658. PMC 5848259. PMID 29117327.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  29. 1 2 Barcaite E, Bartusevicius A, Tameliene R, Kliucinskas M, Maleckiene L, Nadisauskiene R (2008). "Prevalence of maternal group B streptococcal colonisation in European countries". Acta Obstetricia et Gynecologica Scandinavica. 87 (3): 260–271. doi:10.1080/00016340801908759. PMID 18307064. S2CID 25897076.{{cite journal}}: CS1 maint: url-status (link)
  30. 1 2 3 4 5 Rodriguez-Granger J, Alvargonzalez JC, Berardi A, Berner R, Kunze M, Hufnagel M, Melin P, Decheva A, Orefici G, Poyart C, Telford J, Efstratiou A, Killian M, Krizova P, Baldassarri L, Spellerberg B, Puertas A, Rosa-Fraile M (2012). "Prevention of group B streptococcal neonatal disease revisited. The DEVANI European project". European Journal of Clinical Microbiology & Infectious Diseases. 31 (9): 2097–2114. doi:10.1007/s10096-012-1559-0. PMID 22314410. S2CID 15588906.
  31. ↑ Muller AE, Oostvogel PM, Steegers EA, Dörr PJ. (2016). "Morbidity related to maternal group B streptococcal infections". Acta Obstetricia et Gynecologica Scandinavica. 85 (9): 1027–37. doi:10.1080/00016340600780508. PMID 16929406. S2CID 11745321. Archived from the original on 14 January 2021. Retrieved 3 October 2022.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  32. ↑ Cunnimgham, Keveno, Bloom, Spong, Dashe, Hoffman, Casey, Sheffield (2014). Willians Obstetrics (PDF) (24th ed.). McGrawHill. ISBN 978-0-07-179894-5.{{cite book}}: CS1 maint: multiple names: authors list (link)
  33. 1 2 Libster R, Edwards KM, Levent F, Edwards MS, Rench MA, Castagnini LA, Cooper T, Sparks RC, Baker CJ, Shah PE (2012). "Long-term outcomes of group B streptococcal meningitis" (PDF). Pediatrics. 130 (1): e8–15. doi:10.1542/peds.2011-3453. PMID 22689869. S2CID 1013682. Archived (PDF) from the original on 9 September 2016. Retrieved 3 October 2022.
  34. 1 2 3 4 5 6 Puopolo KM, Lynfield R, Cummings JJ; AMERICAN ACADEMY OF PEDIATRICS. COMMITTEE ON FETUS AND NEWBORN; COMMITTEE ON INFECTIOUS DISEASES. (2019). "Management of Infants at Risk for Group B Streptococcal Disease" (PDF). Pediatrics. 144 (2): e20191881. doi:10.1542/peds.2019-1881. PMID 31285392. S2CID 195843897. Archived (PDF) from the original on 27 June 2021. Retrieved 25 November 2019.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  35. 1 2 3 Boyer KM, Gotoff SP (1985). "Strategies for Chemoprophylaxis of GBS Early-Onset Infections1". Strategies for chemoprophylaxis of GBS early-onset infections. Antibiotics and Chemotherapy. Vol. 35. pp. 267–280. doi:10.1159/000410380. ISBN 978-3-8055-3953-1. PMID 3931544.
  36. ↑ Polin RA. (2012). "Management of Neonates With Suspected or Proven Early-Onset Bacterial Sepsis" (PDF). Pediatrics. 129 (5): 1006–1015. doi:10.1542/peds.2012-0541. PMID 22547779. S2CID 230591. Archived (PDF) from the original on 13 January 2021. Retrieved 3 October 2022.
  37. ↑ Martinez E, Mintegi S, Vilar B, Martinez MJ, Lopez A, Catediano E, Gomez B (2015). "Prevalence and predictors of bacterial meningitis in young infants with fever without a source". The Pediatric Infectious Disease Journal. 34 (5): 494–498. doi:10.1097/inf.0000000000000629. PMID 25461476. S2CID 43717212.
  38. ↑ Russell NJ, Seale AC, O'Sullivan C, Le Doare K, Heath PT, Lawn JE, Bartlett L, Cutland C, Gravett M, Ip M, Madhi SA, Rubens CE, Saha SK, Schrag S, Sobanjo-Ter Meulen A, Vekemans J, Baker CJ. (2017). "Risk of Early-Onset Neonatal Group B Streptococcal Disease With Maternal Colonization Worldwide: Systematic Review and Meta-analyses". Clinical Infectious Diseases. 65 (suppl_2): S152-159. doi:10.1093/cid/cix655. PMC 5850448. PMID 29117325.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  39. ↑ Dauby N, Chamekh M, Melin P, Slogrove A, Goetghebuer T (2016). "Increased Risk of Group B Streptococcus Invasive Infection in HIV-Exposed but Uninfected Infants: A Review of the Evidence and Possible Mechanisms". Frontiers in Immunology. 16: 505. doi:10.3389/fimmu.2016.00505. PMC 5110531. PMID 27899925.
  40. 1 2 Baker CJ, Kasper DL (1976). "Correlation of maternal antibody deficiency with susceptibility to neonatal infection with group B Streptococcus". The New England Journal of Medicine. 294 (14): 753–756. doi:10.1056/nejm197604012941404. PMID 768760.
  41. ↑ Baker CJ, Edwards MS, Kasper DL (1981). "Role of antibody to native type III polysaccharide of group B Streptococcus in infant infection". Pediatrics. 68 (4): 544–549. doi:10.1542/peds.68.4.544. PMID 7033911. S2CID 38905874.
  42. 1 2 Edmond KM, Kortsalioudaki C, Scott S, Schrag SJ, Zaidi AK, Cousens S, Heath PT (2012). "Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis" (PDF). The Lancet. 379 (9815): 547–556. doi:10.1016/s0140-6736(11)61651-6. PMID 22226047. S2CID 15438484. Archived (PDF) from the original on 6 October 2022. Retrieved 3 October 2022.
  43. 1 2 3 4 Nanduri SA, Petit S, Smelser C, Apostol M, Alden NB, Harrison LH, Lynfield R, Vagnone PS, Burzlaff K, Spina NL, Dufort EM, Schaffner W, Thomas AR, Farley MM, Jain JH, Pondo T, McGee L, Beall BW, Schrag SJ. (2019). "Epidemiology of Invasive Early-Onset and Late-Onset Group B Streptococcal Disease in the United States, 2006 to 2015: Multistate Laboratory and Population-Based Surveillance". JAMA Pediatrics. 173 (3): 224–33. doi:10.1001/jamapediatrics.2018.4826. PMC 6439883. PMID 30640366.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  44. ↑ Lin FY, Weisman LE, Troendle J, Adams K (2003). "Prematurity Is the Major Risk Factor for Late-Onset Group B Streptococcus Disease". The Journal of Infectious Diseases. 188 (2): 267–271. doi:10.1086/376457. PMID 12854082.
  45. ↑ Boyer KM, Gadzala CA, Kelly PD, Gotoff SP. (1983). "Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. III. Interruption of mother-to-infant transmission". Journal of Infectious Diseases. 148 (5): 810–816. doi:10.1093/infdis/148.5.810. PMID 6355318.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  46. 1 2 "Prevention of Early-onset Neonatal Group B Streptococcal Disease: Green-top Guideline No. 36". BJOG: An International Journal of Obstetrics & Gynaecology. 124 (12): e280–e305. November 2017. doi:10.1111/1471-0528.14821.
  47. ↑ Lin, F; Brenner, RA; Johnson, YR; Azimi, PH; Philips Jb, 3rd; Regan, JA; Clark, P; Weisman, LE; et al. (2001). "The effectiveness of risk-based intrapartum chemoprophylaxis for the prevention of early-onset neonatal group B streptococcal disease". American Journal of Obstetrics and Gynecology. 184 (6): 1204–10. doi:10.1067/mob.2001.113875. PMID 11349189.
  48. ↑ de Cueto M, Sanchez MJ, Sampedro A, Miranda JA, Herruzo AJ, Rosa-Fraile M. (1998). "Timing of intrapartum ampicillin and prevention of vertical transmission of group B streptococcus". Obstetrics and Gynecology. 91 (1): 112–4. doi:10.1016/s0029-7844(97)00587-5. PMID 9464732. S2CID 43765652.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  49. ↑ Berardi A, Rossi C, Biasini A, Minniti S, Venturelli C, Ferrari F, Facchinetti F (2011). "Efficacy of intrapartum chemoprophylaxis less than 4 hours duration". The Journal of Maternal-Fetal & Neonatal Medicine. 24 (4): 619–625. doi:10.3109/14767058.2010.511347. PMID 20828241. S2CID 6697604.
  50. ↑ Desai SH, Kaplan MS, Chen Q, Macy EM. (2017). "Morbidity in Pregnant Women Associated with Unverified Penicillin Allergies, Antibiotic Use, and Group B Streptococcus Infections". The Permanente Journal. 21: 16–080. doi:10.7812/TPP/16-080. PMC 5363897. PMID 28333608.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  51. ↑ Bhattacharya S. (2010). "The facts about Penicillin Allergy: A Review". Journal of Advanced Pharmaceutical Technology & Research. 1 (1): 11–17. PMC 3255391. PMID 22247826.
  52. ↑ Baltimore RS, Huie SM, Meek JI, Schuchat A, O'Brien KL (2001). "Early-onset neonatal sepsis in the era of group B streptococcal prevention". Pediatrics. 108 (5): 1094–1098. doi:10.1542/peds.108.5.1094. PMID 11694686.
  53. ↑ Sutkin G, Krohn MA, Heine RP, Sweet RL (2005). "Antibiotic prophylaxis and non-group B streptococcal neonatal sepsis". Obstetrics & Gynecology. 105 (3): 581–586. doi:10.1097/01.aog.0000153492.30757.2f. PMID 15738028. S2CID 22019440.
  54. ↑ Schrag SJ, Hadler JL, Arnold KE, Martell-Cleary P, Reingold A, Schuchat A (2006). "Risk factors for invasive, early-onset Escherichia coli infections in the era of widespread intrapartum antibiotic use". Pediatrics. 118 (2): 560–566. doi:10.1542/peds.2005-3083. PMID 16882809. S2CID 34908773.
  55. ↑ Cutland, Clare L; Madhi, Shabir A; Zell, Elizabeth R; Kuwanda, Locadiah; Laque, Martin; Groome, Michelle; Gorwitz, Rachel; Thigpen, Michael C; et al. (2009). "Chlorhexidine maternal-vaginal and neonate body wipes in sepsis and vertical transmission of pathogenic bacteria in South Africa: A randomised, controlled trial". The Lancet. 374 (9705): 1909–16. doi:10.1016/S0140-6736(09)61339-8. PMID 19846212. S2CID 23418670.
  56. ↑ Ohlsson, A; Shah, VS; Stade, BC (14 December 2014). "Vaginal chlorhexidine during labour to prevent early-onset neonatal group B streptococcal infection". Cochrane Database of Systematic Reviews. 12 (12): CD003520. doi:10.1002/14651858.CD003520.pub3. PMID 25504106.
  57. 1 2 CDC (1996). "Prevention of Perinatal Group B Streptococcal Disease: A Public Health Perspective". MMWR. 45-RR7: 1–24. Archived from the original on 2 August 2022. Retrieved 3 October 2022.
  58. ↑ Clifford V, Garland SM, Grimwood K (2011). "Prevention of neonatal group B streptococcus disease in the 21st century". Journal of Paediatrics and Child Health. 48 (9): 808–815. doi:10.1111/j.1440-1754.2011.02203.x. PMID 22151082. S2CID 36906520.
  59. ↑ Schrag SJ, Zell ER, Lynfield R, Roome A, Arnold KE, Craig AS, Harrison LH, Reingold A, Stefonek K, Smith G, Gamble M, Schuchat A; Active Bacterial Core Surveillance Team. (2002). "A population-based comparison of strategies to prevent early-onset group B streptococcal disease in neonates". New England Journal of Medicine. 347 (4): 233–239. doi:10.1056/nejmoa020205. PMID 12140298. Archived from the original on 13 December 2022. Retrieved 3 October 2022.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  60. 1 2 3 4 Giménez M, Sanfeliu I, Sierra M, Dopico E, Juncosa T, Andreu A, Lite J, Guardià C, Sánchez F, Bosch J., Article in Spanish. (2015). "Evolución de la sepsis neonatal precoz por Streptococcus agalactiae en el área de Barcelona (2004-2010). Análisis de los fallos del cumplimiento del protocolo de prevención. Group B streptococcal early-onset neonatal sepsis in the area of Barcelona (2004-2010). Analysis of missed opportunities for prevention" (PDF). Enfermedades Infecciosas y Microbiologia Clinica. 33 (7): 446–450. doi:10.1016/j.eimc.2014.10.015. PMID 25541009. Archived from the original (PDF) on 23 February 2016. Retrieved 15 January 2016.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  61. ↑ Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, Craig AS, Schaffner W, Zansky SM, Gershman K, Stefonek KR, Albanese BA, Zell ER, Schuchat A, Schrag SJ; Active Bacterial Core surveillance/Emerging Infections Program Network. (2008). "Epidemiology of Invasive Group B Streptococcal Disease in the United States, 1999-2005". JAMA. 299 (17): 2056–2065. doi:10.1001/jama.299.17.2056. PMID 18460666.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  62. 1 2 Colbourn, T; Asseburg, C; Bojke, L; Philips, Z; Claxton, K; Ades, AE; Gilbert, RE (2007). "Prenatal screening and treatment strategies to prevent group B streptococcal and other bacterial infections in early infancy: Cost-effectiveness and expected value of information analyses". Health Technology Assessment. 11 (29): 1–226, iii. doi:10.3310/hta11290. PMID 17651659.
  63. 1 2 3 Colbourn, T. E; Asseburg, C.; Bojke, L.; Philips, Z.; Welton, N. J; Claxton, K.; Ades, A E; Gilbert, R. E (2007). "Preventive strategies for group B streptococcal and other bacterial infections in early infancy: Cost effectiveness and value of information analyses". BMJ. 335 (7621): 655. doi:10.1136/bmj.39325.681806.AD. PMC 1995477. PMID 17848402.
  64. 1 2 Kaambwa B, Bryan S, Gray J, Milner P, Daniels J, Khan KS, Roberts TE (2010). "Cost-effectiveness of rapid tests and other existing strategies for screening and management of early-onset group B streptococcus during labour". BJOG: An International Journal of Obstetrics & Gynaecology. 117 (13): 1616–1627. doi:10.1111/j.1471-0528.2010.02752.x. PMID 21078057. S2CID 25561127.
  65. 1 2 Vergnano S, Embleton N, Collinson A, Menson E, Bedford Russell A, Heath P (2010). "Missed opportunities for preventing group B streptococcus infection". Archives of Disease in Childhood - Fetal and Neonatal Edition. 95 (1): F72–73. doi:10.1136/adc.2009.160333. PMID 19439431. S2CID 38297857.
  66. ↑ Steer, P.J.; Plumb, J. (2011). "Myth: Group B streptococcal infection in pregnancy: Comprehended and conquered". Seminars in Fetal and Neonatal Medicine. 16 (5): 254–8. doi:10.1016/j.siny.2011.03.005. PMID 21493170.
  67. ↑ Siegel JD, Cushion NB (1996). "Prevention of early-onset group B streptococcal disease: another look at single-dose penicillin at birth". Obstetrics & Gynecology. 87 (5 Pt 1): 692–698. doi:10.1016/0029-7844(96)00004-x. PMID 8677068. S2CID 40716699.
  68. ↑ Velaphi S, Siegel JD, Wendel GD Jr, Cushion N, Eid WM, Sanchez PJ (2003). "Early-onset group B streptococcal infection after a combined maternal and neonatal group B streptococcal chemoprophylaxis strategy". Pediatrics. 111 (3): 541–547. doi:10.1542/peds.111.3.541. PMID 12612234.
  69. ↑ Woodgate PG, Flenady V, Steer PA (2004). "Intramuscular penicillin for the prevention of early onset group B streptococcal infection in newborn". The Cochrane Database of Systematic Reviews (3): CD003667. doi:10.1002/14651858.CD003667.pub2. PMC 9029842. PMID 15266494.
  70. ↑ GROUP B STREP SUPPORT. "FAQs35. Carrying GBS and home birth?". Archived from the original on 13 December 2022. Retrieved 4 March 2021.
  71. 1 2 3 Hughes RG, Brocklehurst P, Steer PJ, Heath P, Stenson BM on behalf of the Royal College of Obstetricians and Gynaecologists. (2017). "Prevention of Early-onset Neonatal Group B Streptococcal Disease Green-top Guideline No. 36. September 2017". BJOG: An International Journal of Obstetrics and Gynaecology. 124 (12): e280–e305. doi:10.1111/1471-0528.14821. PMID 28901693.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  72. 1 2 Yancey MK, Schuchat A, Brown LK, Ventura VL, Markenson GR. (1996). "The accuracy of late antenatal screening cultures in predicting genital group B streptococcal colonization at delivery". Obstetrics & Gynecology. 88 (5): 811–815. doi:10.1016/0029-7844(96)00320-1. PMID 8885919.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  73. ↑ Valkenburg-van den Berg AW, Houtman-Roelofsen RL, Oostvogel PM, Dekker FW, Dorr PJ, Sprij AJ (2010). "Timing of group B streptococcus screening in pregnancy: a systematic review". Gynecologic and Obstetric Investigation. 69 (3): 174–183. doi:10.1159/000265942. PMID 20016190. S2CID 26709882.
  74. ↑ Price D, Shaw E, Howard M, Zazulak J, Waters H, Kaczorowski J (2006). "Self-sampling for group B Streptococcus in women 35 to 37 weeks pregnant is accurate and acceptable: a randomized cross-over trial". Journal of Obstetrics and Gynaecology Canada. 28 (12): 1083–8. doi:10.1016/s1701-2163(16)32337-4. PMID 17169231.
  75. ↑ Hicks P, Diaz-Perez MJ (2009). "Patient self-collection of group B streptococcal specimens during pregnancy" (PDF). The Journal of the American Board of Family Medicine. 22 (2): 136–140. doi:10.3122/jabfm.2009.02.080011. PMID 19264936. Archived (PDF) from the original on 16 January 2021. Retrieved 22 February 2021.
  76. ↑ Arya A; Cryan B; O'Sullivan K; Greene RA; Higgins JR. (2008). "Self-collected versus health professional-collected genital swabs to identify the prevalence of group B streptococcus: A comparison of patient preference and efficacy". European Journal of Obstetrics & Gynecology and Reproductive Biology. 139 (1): 32–45. doi:10.1016/j.ejogrb.2007.12.005. PMID 18255214.
  77. ↑ Rosa-Fraile M, Camacho-Muñoz E, Rodríguez-Granger J, Liébana-Martos C (2005). "Specimen storage in transport medium and detection of group B streptococci by culture". Journal of Clinical Microbiology. 43 (2): 928–930. doi:10.1128/jcm.43.2.928-930.2005. PMC 548104. PMID 15695709.
  78. ↑ UK Gov. "SMI B 58: detection of carriage of group B streptococci. Updated 2018". Archived from the original on 18 January 2021. Retrieved 28 February 2021.
  79. ↑ Gil, EG; Rodríguez, MC; Bartolomé, R; Berjano, B; Cabero, L; Andreu, A (1999). "Evaluation of the Granada agar plate for detection of vaginal and rectal group B streptococci in pregnant women". Journal of Clinical Microbiology. 37 (8): 2648–2651. doi:10.1128/JCM.37.8.2648-2651.1999. PMC 85303. PMID 10405415.
  80. ↑ Claeys, G.; Verschraegen, G.; Temmerman, M. (2001). "Modified Granada Agar Medium for the detection of group B streptococcus carriage in pregnant women". Clinical Microbiology and Infection. 7 (1): 22–24. doi:10.1046/j.1469-0691.2001.00156.x. PMID 11284939. Archived from the original on 13 December 2022. Retrieved 4 March 2021.
  81. 1 2 Where can I get the ECM test?. "ECM Testing". Group B Strep Support. Archived from the original on 21 April 2016. Retrieved 28 February 2021.
  82. ↑ "Group B Streptococcus Screening Test". Medisave UK Ltd. Archived from the original on 3 December 2019. Retrieved 28 February 2021.
  83. ↑ "Testing for Group B Streptococcus". The Doctors Laboratory. Archived from the original on 4 March 2016. Retrieved 28 February 2021.
  84. ↑ Buchan BW, Faron ML, Fuller D, Davis TE, Mayne D, Ledeboer NA (2015). "Multicenter Clinical Evaluation of the Xpert GBS LB Assay for Detection of Group B Streptococcus in Prenatal Screening Specimens". Journal of Clinical Microbiology. 53 (2): 443–448. doi:10.1128/jcm.02598-14. PMC 4298547. PMID 25411176.
  85. ↑ Daniels J, Gray J, Pattison H, Roberts T, Edwards E, Milner P, Spicer L, King E, Hills RK, Gray R, Buckley L, Magill L, Elliman N, Kaambwa B, Bryan S, Howard R, Thompson P, Khan KS (2009). "Rapid testing for group B streptococcus during labour: a test accuracy study with evaluation of acceptability and cost-effectiveness". Health Technology Assessment. 13 (42): 1–154, iii–iv. doi:10.3310/hta13420. PMID 19778493.
  86. 1 2 Pulver LS, Hopfenbeck MM, Young PC, Stoddard GJ, Korgenski K, Daly J, Byington CL (2009). "Continued early onset group B streptococcal infections in the era of intrapartum prophylaxis" (PDF). Journal of Perinatology. 29 (1): 0–25. doi:10.1038/jp.2008.115. PMID 18704032.
  87. ↑ Melin P. (2011). "Neonatal group B streptococcal disease: from pathogenesis to preventive strategies". Clinical Microbiology and Infection. 17 (9): 1294–1303. doi:10.1111/j.1469-0691.2011.03576.x. PMID 21672083. Archived from the original on 13 December 2022. Retrieved 3 October 2022.
  88. ↑ Berardi A, Lugli L, Baronciani D, Rossi C, Ciccia M, Creti R, Gambini L, Mariani S, Papa I, Tridapalli E, Vagnarelli F, Ferrari F; GBS Prevention Working Group of Emilia-Romagna. (2010). "Group B Streptococcus early-onset disease in Emilia-romagna: review after introduction of a screening-based approach". The Pediatric Infectious Disease Journal. 29 (2): 115–121. doi:10.1097/inf.0b013e3181b83cd9. PMID 19915512. S2CID 31548613.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  89. ↑ Schrag SJ, Verani JR (2013). "Intrapartum antibiotic prophylaxis for the prevention of perinatal group B streptococcal disease: Experience in the United States and implications for a potential group B streptococcal vaccine". Vaccine. 31S: D20–26. doi:10.1016/j.vaccine.2012.11.056. PMID 23219695. Archived from the original on 13 December 2022. Retrieved 3 October 2022.
  90. ↑ Heath PT, Balfour G, Weisner AM, Efstratiou A, Lamagni TL, Tighe H, O'Connell LA, Cafferkey M, Verlander NQ, Nicoll A, McCartney AC; PHLS Group B Streptococcus Working Group. (2004). "Group B streptococcal disease in UK and Irish infants younger than 90 days". The Lancet. 363 (9405): 292–294. doi:10.1016/s0140-6736(03)15389-5. PMID 14751704. S2CID 22371160.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  91. 1 2 Doare K, Heath PT (2013). "An overview of global GBS epidemiology". Vaccine. 31 Suppl 4: D7–12. doi:10.1016/j.vaccine.2013.01.009. PMID 23973349.
  92. ↑ Brigtsen A.K.; Jacobsen A.F.; Dedi L.; Melby K.K.; Fugelseth D.; Whitelaw A. (2015). "Maternal colonization with Group B Streptococcus Is associated with an increased rate of infants transferred to the neonatal intensive care unit". Neonatology. 108 (3): 157–163. doi:10.1159/000434716. PMID 26182960. S2CID 24711146.
  93. ↑ Carbonell-Estrany X, Figueras-Aloy J, Salcedo-Abizanda S, de la Rosa-Fraile M, Castrillo Study Group (2008). "Probable early-onset group B streptococcal neonatal sepsis: a serious clinical condition related to intrauterine infection". Archives of Disease in Childhood - Fetal and Neonatal Edition. 93 (2): F85–89. doi:10.1136/adc.2007.119958. PMID 17704105. S2CID 10300571.
  94. ↑ Luck, Suzanne; Torny, Michael; d'Agapeyeff, Katrina; Pitt, Alison; Heath, Paul; Breathnach, Aoadhan; Russell, Alison Bedford (2003). "Estimated early-onset group B streptococcal neonatal disease". The Lancet. 361 (9373): 1953–1954. doi:10.1016/S0140-6736(03)13553-2. PMID 12801740. S2CID 33025300.
  95. ↑ Lamagni TL, Keshishian C, Efstratiou A, Guy R, Henderson KL, Broughton K, Sheridan E (2013). "Emerging Trends in the Epidemiology of Invasive Group B Streptococcal Disease in England and Wales, 1991–2010". Clinical Infectious Diseases. 57 (5): 682–688. doi:10.1093/cid/cit337. PMID 23845950.
  96. ↑ CDC. "Group B Strep (GBS)-Clinical Overview". Archived from the original on 21 December 2015. Retrieved 10 January 2016.
  97. ↑ Baker CJ. (2013). "The spectrum of perinatal group B streptococcal disease". Vaccine. 31s: D3–6. doi:10.1016/j.vaccine.2013.02.030. PMID 23973344.
  98. ↑ Lopez Sastre J, Fernandez Colomer B, Coto Cotallo Gil D, Members of "Grupo de Hospitales Castrillo" (2009). "Neonatal Sepsis of Vertical Transmission. An epidemiological study from the "Grupo de Hospitales Castrillo"". Early Human Development. 85 (10): S100. doi:10.1016/j.earlhumdev.2009.08.049.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  99. ↑ Sociedad Española Neonatología. "Grupo Castrillo". Archived from the original on 29 November 2021. Retrieved 1 March 2021.
  100. ↑ Antonia Andreu , Isabel Sanfeliu, Lluis Viñas, Margarita Barranco, Jordi Bosch, Eva Dopico, Celia Guardia, Teresa Juncosa, Josep Lite, Lurdes Matas, Ferrán Sánchez, Montse Sierr (2003). "Declive de la incidencia de la sepsis perinatal por estreptococo del grupo B (Barcelona 1994-2001).Relación con las políticas profilácticas". Enfermedades Infecciosas y Microbiología Clínica. 21 (4): 174–9. doi:10.1016/s0213-005x(03)72913-9. PMID 12681128. Archived from the original on 13 December 2022. Retrieved 5 March 2021.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  101. ↑ Albouy-Llaty, Marion; Nadeau, Cédric; Descombes, Emmanuelle; Pierre, Fabrice; Migeot, Virginie (2011). "Improving perinatal Group B streptococcus screening with process indicators". Journal of Evaluation in Clinical Practice. 18 (4): 727–733. doi:10.1111/j.1365-2753.2011.01658.x. PMID 21414110.
  102. 1 2 3 VN Raabe and AL Shane (2019). "Group B Streptococcus (Streptococcus agalactiae)". Microbiology Spectrum. 7 (2). doi:10.1128/microbiolspec.GPP3-0007-2018. PMC 6432937. PMID 30900541.
  103. ↑ Seale AC, Bianchi-Jassir F, Russell NJ, Kohli-Lynch M, Tann CJ, Hall J, Madrid L, Blencowe H, Cousens S, Baker CJ, Bartlett L, Cutland C, Gravett MG, Heath PT, Ip M, Le Doare K, Madhi SA, Rubens CE, Saha SK, Schrag SJ, Sobanjo-Ter Meulen A, Vekemans J, Lawn JE. (2017). "Estimates of the Burden of Group B Streptococcal Disease Worldwide for Pregnant Women, Stillbirths, and Children". Clinical Infectious Diseases. 65 (Suppl 2): S200-209. doi:10.1093/cid/cix664. PMC 5849940. PMID 29117332.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  104. ↑ Benitz WE, Gould JB, Druzin ML (1999). "Risk factors for early-onset group B streptococcal sepsis: estimation of odds ratios by critical literature review" (PDF). Pediatrics. 103 (6): e77. doi:10.1542/peds.103.6.e77. PMID 10353974. Archived (PDF) from the original on 13 December 2022. Retrieved 3 October 2022.
  105. ↑ Royal College of Obstetricians and GynaecologistsGuideline No. 36 November 2003. "PREVENTION OF EARLY ONSET NEONATAL GROUP B STREPTOCOCCAL DISEASE" (PDF). Archived (PDF) from the original on 13 December 2022. Retrieved 2 March 2021.
  106. ↑ Heath, Paul T; Balfour, Gail; Weisner, Abbie M; Efstratiou, Androulla; Lamagni, Theresa L; Tighe, Helen; O'Connell, Liam AF; Cafferkey, Mary; et al. (2004). "Group B streptococcal disease in UK and Irish infants younger than 90 days". The Lancet. 363 (9405): 292–294. doi:10.1016/S0140-6736(03)15389-5. PMID 14751704. S2CID 22371160.
  107. ↑ Health Protection Report Vol. 5 No. 46 – 18 November 2011 ·. "Pyogenic and non-pyogenic streptococcal bacteraemia, England, Wales and Northern Ireland: 2010". Health Protection Report. Archived from the original on 14 July 2014. Retrieved 11 January 2016.
  108. ↑ Cromwell D, Joffe T, van der Meulen J, Dhillon C, Hughes R, Murphy D (2007). The Prevention of Early-onset Neonatal Group B Streptococcal Disease in UK Obstetric Units (PDF). Royal College of Obstetricians and Gynaecologists and London School of Hygiene and Tropical Medicine. ISBN 978-1-904752-37-0. Archived (PDF) from the original on 23 June 2015. Retrieved 11 January 2016.
  109. ↑ RCOG. "Audit of current practice in preventing early-onset neonatal group B streptococcal disease in the UK" (PDF). Archived (PDF) from the original on 6 May 2017. Retrieved 2 February 2016.
  110. ↑ GBS Support UK & RCOG (Diciembre de 2017). "Group B Streptococcus (GBS) in pregnancy and newborn babies" (PDF). Archived from the original (PDF) on 22 December 2017. Retrieved 25 November 2019.
  111. ↑ Screening for infections.1.8.9 Group B streptococcus. "Antenatal care for uncomplicated pregnancies.NICE guidelines [CG62] : March 2008". NICE National Institute for Health and Care Excellence. Archived from the original on 13 December 2022. Retrieved 27 November 2019.
  112. ↑ "Recommendations | Antenatal care | Guidance | NICE". www.nice.org.uk. Archived from the original on 13 December 2022. Retrieved 21 May 2022.
  113. ↑ "Recommendations | Neonatal infection: antibiotics for prevention and treatment | Guidance | NICE". www.nice.org.uk. Archived from the original on 13 December 2022. Retrieved 21 May 2022.
  114. ↑ UK National Screening Committee. "Current UK NSC from the UK National Screening Committee (UK NSC)". Archived from the original on 17 March 2021. Retrieved 4 March 2021.
  115. ↑ "Leading baby charity devastated by decision not to introduce life saving screening of pregnant women.2012". campaign-archive2.com. Archived from the original on 13 December 2022. Retrieved 4 March 2021.
  116. ↑ Centers for Disease Control and Prevention- CDC, MMWR (2002). "Prevention of Perinatal Group B Streptococcal Disease Revised Guidelines from CDC. 2002". Morbidity and Mortality Weekly Report. 51-RR11: 1–22. Archived from the original on 18 October 2010. Retrieved 4 March 2021.
  117. ↑ CDC. "Prevention Guidelines. 2019 Guidelines Update". Archived from the original on 18 March 2021. Retrieved 4 March 2021.
  118. ↑ Laura Filkins; Jocelyn R. Hauser; Barbara Robinson-Dunn; Robert Tibbetts; Bobby L. Boyanton; Paula Revell (2020). Sandra S. Richter (ed.). "American Society for Microbiology Provides 2020 Guidelines for Detection and Identification of Group B Streptococcus". Journal of Clinical Microbiology. 59 (1): e01230. doi:10.1128/JCM.01230-20. PMC 7771461. PMID 33115849. S2CID 226049927.
  119. ↑ Money D, Allen VM. (2018). "No 298 - Prévention de l'infection néonatale à streptocoques du groupe B d'apparition précoce". Journal of Obstetrics and Gynaecology Canada. 40 (8): e675–e686. doi:10.1016/j.jogc.2018.05.033. PMID 30103892. S2CID 51980587.
  120. ↑ Alós Cortés JI, Andreu Domingo A, Arribas Mir L, Cabero Roura L, Cueto Lopez M, López Sastre J, Melchor Marcos JC, Puertas Prieto A, de la Rosa Fraile M, Salcedo Abizanda S, Sánchez Luna M, Sánchez Pérez MJ, Torrejón Cardoso R. (2012). "Prevención de la infección perinatal por estreptococo del grupo B. Recomendaciones españolas revisadas 2012" (PDF). Revista Espanola de Quimioterapia. 25 (1): 79–88. PMID 22488547. Archived (PDF) from the original on 13 December 2022. Retrieved 25 November 2019.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  121. ↑ Surbek D.Kommission für Qualitätssicherung der SGGG/gynécologie suisse (2007). "Prophylaxe der frühen Neugeborenensepsis durch Streptokokken der Gruppe B-Prevention of early neonatal sepsis by GBS". Gynäkologisch-geburtshilfliche Rundschau. 47 (2): 103–104. doi:10.1159/000100342. PMID 17440274. S2CID 77887846. Archived from the original on 13 January 2021. Retrieved 3 October 2022.
  122. ↑ Leitlinien der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI) Deutschen Gesellschaft für Gynäkologie und Geburtshilfe, Deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI), und Deutsche Gesellschaft für Perinatale Medizin (DGPM). "Prophylaxe der Neugeborensepsis - frühe Form - durch Streptokokken der Gruppe B - Prevention of neonatal sepsis - early form - by GBS" (PDF). Archived (PDF) from the original on 6 July 2016. Retrieved 2 March 2021.{{cite web}}: CS1 maint: multiple names: authors list (link)
  123. ↑ Kotarski J, Heczko PB, Lauterbach R, Niemiec T, Leszczyńska- Gorzelak B (2008). "Rekomendacje polskiego towarzystwa ginekologicznego dotyczące wykrywania nosicielstwa paciorkowców grupy B (GBS) u kobiet w ciąży i zapobiegania zakażeniom u noworodków--Recommendations Polish Gynecological Society for the detection of carriers of GBS in pregnant women and prevent infections in newborns" (PDF). Ginekol Pol. 79: 221–223. Archived (PDF) from the original on 20 September 2021. Retrieved 3 October 2022.
  124. ↑ A. Měchurová; V. Unzeitig; J. Mašata; P. Švihovec (2013). "Diagnostika a léčba streptokoků skupiny B v těhotenství a za porodu – doporučený postup---Diagnosis and treatment of GBS in pregnancy and during birth - Recommendations" (PDF). Klin Mikrobiol Infekc Lek. 12: 11–14.{{cite journal}}: CS1 maint: url-status (link)
  125. ↑ Agence Nationale d'Accreditation et d'Evaluation en Santé (2001). "Prévention anténatale du risque infectieux bactérien néonatal précoce.2001" (PDF). Archived (PDF) from the original on 13 December 2022. Retrieved 2 March 2021.
  126. ↑ Belgian Health Council. "Prevention of perinatal group B streptococcal infections. Guidelines. 2003" (PDF). Archived from the original (PDF) on 4 March 2016. Retrieved 25 November 2019.
  127. ↑ Nederlandse Vereniging voor Obstetrie en Gynaecologie. "2008. PREVENTIE VAN NEONATALE GROEP-B-STREPTOKOKKENZIEKTE (GBS-ZIEKTE) Versie 2.0" (PDF). Archived (PDF) from the original on 18 August 2019. Retrieved 25 November 2019.
  128. ↑ Royal Australian and New Zealand College of Obstetricians and Gynaecologists. RANZCOG. "Streptococcus (GBS) in Pregnancy: Screening and Management. July 2019.»" (PDF). Archived (PDF) from the original on 13 December 2022. Retrieved 25 November 2019.
  129. 1 2 Skoff TH, Farley MM, Petit S, Craig AS, Schaffner W, Gershman K, Harrison LH, Lynfield R, Mohle-Boetani J, Zansky S, Albanese BA, Stefonek K, Zell ER, Jackson D, Thompson T, Schrag SJ (2009). "Increasing Burden of Invasive Group B Streptococcal Disease in Nonpregnant Adults, 1990–2007". Clinical Infectious Diseases. 49 (1): 85–92. doi:10.1086/599369. PMID 19480572.
  130. ↑ Farley MM. (2001). "Group B Streptococcal Disease in Nonpregnant Adults". Clinical Infectious Diseases. 33 (4): 556–561. doi:10.1086/322696. PMID 11462195.
  131. ↑ Edwards MS,. Baker CJ. (2005). "Group B streptococcal infections in elderly adults". Clinical Infectious Diseases. 41 (6): 839–847. doi:10.1086/432804. PMID 16107984.
  132. ↑ Collin SM, Shetty N, Lamagni T (2020). "Invasive Group B Streptococcus Infections in Adults, England, 2015–2016". Emerg Infect Dis. 26 (6): 1174–1181. doi:10.3201/eid2606.191141. PMC 7258460. PMID 32441619.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  133. 1 2 3 Graux, E; Hites, M; Martiny, D; Maillar, E; Delforge, M; Melin; P; Dauby, N (2020). "Invasive group B Streptococcus among non-pregnant adults in Brussels-Capital Region, 2005–2019". European Journal of Clinical Microbiology and Infectious Diseases. 40 (3): 515–523. doi:10.1007/s10096-020-04041-0. PMC 7498195. PMID 32944894.
  134. ↑ Al Akhrass F, Abdallah L, Berger S, Hanna R, Reynolds N, Thompson S, Hallit R, Schlievert PM. (2013). "Streptococcus agalactiae toxic shock-like syndrome: two case reports and review of the literature". Medicine. 92 (1): 10–14. doi:10.1097/MD.0b013e31827dea11. PMC 5370747. PMID 23263717.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  135. ↑ Group B Strep Support (GBSS) (24 June 2019). "Home»Get Involved»Campaign»Group B Strep Awareness Month Group B Strep Awareness Month". Archived from the original on 6 July 2021. Retrieved 3 March 2021.
  136. ↑ "Welcome". Archived from the original on 2 October 2022. Retrieved 3 October 2022.
  137. ↑ Jordan HT, Farley MM, Craig A, Mohle-Boetani J, Harrison LH, Petit S, Lynfield R, Thomas A, Zansky S, Gershman K, Albanese BA, Schaffner W, Schrag SJ; Active Bacterial Core Surveillance (ABCs)/Emerging Infections Program Network, CDC (2008). "Revisiting the need for vaccine prevention of late-onset neonatal group B streptococcal disease: a multistate, population-based analysis". The Pediatric Infectious Disease Journal. 27 (12): 1057–1064. doi:10.1097/inf.0b013e318180b3b9. PMID 18989238. S2CID 1533957. Archived from the original on 13 December 2022. Retrieved 3 October 2022.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  138. ↑ Edwards MS, Rench MA, Rinaudo CD, Fabbrini M, Tuscano G, Buffi G, Bartolini E, Bonacci S, Baker CJ, Margarit I (2016). "Immune Responses to Invasive Group B Streptococcal Disease in Adults". Emerging Infectious Diseases. 22 (11): 1877–1883. doi:10.3201/eid2211.160914. PMC 5088039. PMID 27767008.
  139. ↑ "GBS vaccine research and development technical roadmap and WHO Preferred Product Characteristics". World Health Organization. Archived from the original on 22 April 2017. Retrieved 30 November 2019.
  140. ↑ "Group B Streptococcus infection causes an estimated 150,000 preventable stillbirths and infant deaths every year". World Health Organization. 6 November 2017. Archived from the original on 9 November 2017. Retrieved 4 March 2021.
  141. 1 2 Baker CJ, Carey VJ, Rench MA, Edwards MS, Hillier SH, Kasper DL, Platt R (2014). "Maternal Antibody at Delivery Protects Neonates From Early Onset Group B Streptococcal Disease". Journal of Infectious Diseases. 209 (5): 781–788. doi:10.1093/infdis/jit549. PMC 3923540. PMID 24133184.
  142. ↑ Madhi, Shabir A; Cutland, Clare L; Jose, Lisa; Koen, Anthonet; Govender, Niresha; Wittke, Frederick; Olugbosi, Morounfolu; Meulen, Ajoke Sobanjo-ter; Baker, Sherryl; Dull, Peter M; Narasimhan, Vas; Slobod, Karen (2016). "Safety and immunogenicity of an investigational maternal trivalent group B streptococcus vaccine in healthy women and their infants: a randomised phase 1b/2 trial". The Lancet Infectious Diseases. 16 (8): 923–934. doi:10.1016/S1473-3099(16)00152-3. PMID 27139805.
  143. 1 2 Edwards MS, Gonik B (2013). "Preventing the broad spectrum of perinatal morbidity and mortality throughgh group B streptococcal vaccination". Vaccine. 31S: D66–71. doi:10.1016/j.vaccine.2012.11.046. PMID 23200934.
  144. ↑ Rodriguez-Granger J, Alvargonzalez JC, Berardi A, Berner R, Kunze M, Hufnagel M, Melin P, Decheva A, Orefici G, Poyart C, Telford J, Efstratiou A, Killian M, Krizova P, Baldassarri L, Spellerberg B, Puertas A, Rosa-Fraile M (2012). "Prevention of group B streptococcal neonatal disease revisited. The DEVANI European project". European Journal of Clinical Microbiology & Infectious Diseases. 31 (9): 2097–2114. doi:10.1007/s10096-012-1559-0. PMID 22314410. S2CID 15588906.{{cite journal}}: CS1 maint: url-status (link)
  145. 1 2 Heath PT. (2016). "Status of vaccine research and development of vaccines for GBS". Vaccine. 34 (26): 2876–2879. doi:10.1016/j.vaccine.2015.12.072. PMID 26988258.
  146. ↑ Song JY, Lim JH, Lim S, Yong Z, Seo HS (2018). "Progress toward a group B streptococcal vaccine". Human Vaccines & Immunotherapeutics. 14 (11): 2669–2681. doi:10.1080/21645515.2018.1493326. PMC 6314413. PMID 29995578.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  147. ↑ Ria, Francesco; Gupalova, T.; Leontieva, G.; Kramskaya, T.; Grabovskaya, K.; Bormotova, E.; Korjevski, D.; Suvorov, A. (2018). "Development of experimental GBS vaccine for mucosal immunization". PLOS ONE. 13 (5): e0196564. Bibcode:2018PLoSO..1396564G. doi:10.1371/journal.pone.0196564. ISSN 1932-6203. PMC 5935385. PMID 29727446.
  148. 1 2 Carreras-Abad C, Ramkhelawon L, Heath PT, Le Doare K. (2020). "A Vaccine Against Group B Streptococcus: Recent Advances". Infection and Drug Resistance. 13: 1263–1272. doi:10.2147/IDR.S203454. PMC 7196769. PMID 32425562.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  149. ↑ Nuccitelli A, Rinaudo CD, Maione D (2015). "Group B Streptococcus vaccine: state of the art". Therapeutic Advances in Vaccines. 3 (3): 76–90. doi:10.1177/2051013615579869. PMC 4530403. PMID 26288735.
  150. ↑ Davies HG, Carreras-Abad C, Le Doare K, Heath PT. (2019). "Group B Streptococcus: Trials and Tribulations" (PDF). The Pediatric Infectious Disease Journal. 38(6S Suppl 1.) (6S Suppl 1): S72-76. doi:10.1097/INF.0000000000002328. PMID 31205250.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  151. ↑ Delannoy CM, Crumlish M, Fontaine MC, Pollock J, Foster G, Dagleish MP, Turnbull JF, Zadoks RN (2013). "Human Streptococcus agalactiae strains in aquatic mammal and fish". BMC Microbiology. 13: 41. doi:10.1186/1471-2180-13-41. PMC 3585737. PMID 23419028.
  152. ↑ Ruegg PL (2017). "A 100-Year Review: Mastitis detection, management, and prevention". Journal of Dairy Science. 100 (12): 10381–10397. doi:10.3168/jds.2017-13023. PMID 29153171. Archived from the original on 13 December 2022. Retrieved 29 November 2019.
  153. ↑ Keefe GP (1997). "Streptococcus agalactiae mastitis: a review". The Canadian Veterinary Journal. 38 (7): 429–37. PMC 1576741. PMID 9220132.
  154. ↑ Evans JJ, Klesius PH, Pasnik DJ, Bohnsack JF (2009). "Human Streptococcus agalactiae isolate in Nile tilapia (Oreochromis niloticus)". Emerging Infectious Diseases. 15 (5): 774–776. doi:10.3201/eid1505.080222. PMC 2687030. PMID 19402966.
  155. ↑ Liu G, Zhang W, Lu C (2013). "Comparative genomics analysis of Streptococcus". BMC Genomics. 14: 775. doi:10.1186/1471-2164-14-775. PMC 3831827. PMID 24215651.
  156. ↑ Li LP, Wang R, Liang WW1, Huang T1, Huang Y2, Luo FG, Lei AY, Chen M, Gan X (2015). "Development of live attenuated Streptococcus agalactiae vaccine for tilapia via continuous passage in vitro". Fish & Shellfish Immunology. 45 (2): 955–963. doi:10.1016/j.fsi.2015.06.014. PMID 26087276.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  157. ↑ Zhang D, Gao Y, Li Q, Ke X, Liu Z, Lu M, Shi C. (2019). "An effective live attenuated vaccine against Streptococcus agalactiae infection in farmed Nile tilapia (Oreochromis niloticus)". Fish & Shellfish Immunology. S1050-4648: 31087–3. doi:10.1016/j.fsi.2019.11.044. PMID 31751658. S2CID 208226408.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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