Ipratropium bromide/salbutamol

Ipratropium bromide/salbutamol, sold under the brand name Duoneb among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD).[3][4][5] It contains ipratropium (an anticholinergic) and salbutamol (albuterol, a β2-adrenergic agonist).[3]

Ipratropium bromide/salbutamol
Combination of
Ipratropium bromideMuscarinic antagonist
SalbutamolShort-acting β2-adrenergic agonist
Clinical data
Trade namesCombivent, Duoneb, Breva, others
AHFS/Drugs.comProfessional Drug Facts
MedlinePlusa601063
License data
Routes of
administration		Inhalation
ATC code
Legal status
Legal status
Identifiers
CAS Number
  (verify)

Common side effects include sore throat, muscle cramps, and nausea.[3] Other side effects may include bronchospasm, allergic reactions, and upper respiratory tract infections.[3] Safety in pregnancy is unclear.[6][3]

The combination was approved for medical use in the United States in 1996.[7] It is available as a generic medication.[4] In 2020, it was the 150th most commonly prescribed medication in the United States, with more than 3 million prescriptions.[8][9]

Society and culture

Since Combivent contains a chlorofluorocarbon-based propellant, its use was discontinued in 2013 in the United States and other countries. This was because Chlorofluorocarbons (CFC) are attributed to depletion of the ozone layer.[10]

References
  1. "DuoNeb". DailyMed. Retrieved 30 October 2022.
  2. "Combivent (ipratropium bromide and albuterol sulfate) Inhalation Aerosol". DailyMed. Retrieved 30 October 2022.
  3. "Combivent Respimat- ipratropium bromide and albuterol spray, metered". DailyMed. 24 January 2022. Retrieved 30 October 2022.
  4. British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 247. ISBN 9780857113382.
  5. Gordon J, Panos RJ (March 2010). "Inhaled albuterol/salbutamol and ipratropium bromide and their combination in the treatment of chronic obstructive pulmonary disease". Expert Opinion on Drug Metabolism & Toxicology. 6 (3): 381–92. doi:10.1517/17425251003649549. PMID 20163324. S2CID 31806856.
  6. "Albuterol / ipratropium Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
  7. "Ipratropium and Albuterol - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 18 April 2019.
  8. "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
  9. "Albuterol; Ipratropium - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
  10. Research, Center for Drug Evaluation and (3 November 2018). "Phase Out of Combivent Inhalation Aerosol - Questions and Answers". FDA.


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