Phenacemide

Phenacemide
Clinical data
Trade names	Phenurone
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	N03AX07 (WHO) ;
Pharmacokinetic data
Elimination half-life	22–25 hours
Identifiers
	IUPAC name N-Carbamoyl-2-phenyl-acetamide;
CAS Number	63-98-9 ;
PubChem CID	4753;
IUPHAR/BPS	7265;
DrugBank	DB01121 ;
ChemSpider	4589 ;
UNII	PAI7J52V09;
KEGG	D00504 ;
ChEMBL	ChEMBL918 ;
CompTox Dashboard (EPA)	DTXSID6023442 ;
ECHA InfoCard	100.000.519
Chemical and physical data
Formula	C9H10N2O2
Molar mass	178.191 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(NC(=O)N)Cc1ccccc1;
	InChI InChI=1S/C9H10N2O2/c10-9(13)11-8(12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13) ; Key:XPFRXWCVYUEORT-UHFFFAOYSA-N ;
	(verify)

Phenacemide (INN, BAN) (brand name Phenurone), also known as phenylacetylurea, is an anticonvulsant of the ureide (acetylurea) class.[1] It is a congener and ring-opened analogue of phenytoin (a hydantoin),[2][3] and is structurally related to the barbiturates and to other hydantoins.[4] Phenacemide was introduced in 1949 for the treatment of epilepsy, but was eventually withdrawn due to toxicity.[2][3]

References

C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1578–. ISBN 978-0-412-46630-4.
Conceptual Pharmacology. Universities Press. 2010. pp. 236–. ISBN 978-81-7371-679-9.
deStevens, G.; Zingel, V.; Leschke, C.; Hoeprich, P.D.; Schultz, R.M.; Mehrotra, P.K.; Batra, S.; Bhaduri, A.P.; Saxena, A.K.; Saxena, M., eds. (11 November 2013). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques. Basel: Birkhäuser. pp. 217–. ISBN 978-3-0348-7161-7. Retrieved 3 September 2016.
S. S. Kadam (1 July 2007). PRINCIPLES OF MEDICINAL CHEMISTRY Vol. - II. Pragati Books Pvt. Ltd. pp. 147–. ISBN 978-81-85790-03-9.

Diseases Database (DDB): 34078
MedlinePlus DrugInfo uspdi-202454
Coker S (1986). "The use of phenacemide for intractable partial complex epilepsy in children". Pediatr Neurol. 2 (4): 230–2. doi:10.1016/0887-8994(86)90053-6. PMID 3508693.
Coker S, Holmes E, Egel R (1987). "Phenacemide therapy of complex partial epilepsy in children: determination of plasma drug concentrations". Neurology. 37 (12): 1861–6. doi:10.1212/wnl.37.12.1861. PMID 3683877. S2CID 219205208.

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