Cafaminol

Cafaminol
Clinical data
Trade names	Rhinetten, Rhinoptil
Other names	Methylcoffanolamine; 8-[(2-Hydroxyethyl)(methyl)amino]caffeine
ATC code	None;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 8-[(2-hydroxyethyl)(methyl)amino]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione;
CAS Number	30924-31-3;
PubChem CID	35685;
ChemSpider	32824;
UNII	0L1S25NC1L;
ChEMBL	ChEMBL2104570;
CompTox Dashboard (EPA)	DTXSID60184916 ;
ECHA InfoCard	100.045.795
Chemical and physical data
Formula	C11H17N5O3
Molar mass	267.289 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N(c1nc(n(c1C(=O)N2C)C)N(CCO)C)C;
	InChI InChI=1S/C11H17N5O3/c1-13(5-6-17)10-12-8-7(14(10)2)9(18)16(4)11(19)15(8)3/h17H,5-6H2,1-4H3; Key:ZGNRRVAPHPANFI-UHFFFAOYSA-N;

Cafaminol (brand names Rhinetten, Rhinoptil), also known as methylcoffanolamine, is a vasoconstrictor and anticatarrhal of the methylxanthine family related to caffeine which is used as a nasal decongestant in Germany.[1][2][3][4][5][6] It was introduced in 1974 and was still in use as of 2000.[3][2]

References

J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 205–. ISBN 978-1-4757-2085-3.
Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 157–. ISBN 978-3-88763-075-1.
William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia. Elsevier. pp. 784–. ISBN 978-0-8155-1856-3.
Szirmai E (1969). "[A new treatment for colds using a new caffeine derivative, methylcoffanolamine]". Praxis (in German). 58 (13): 412–4. PMID 5818666.
Walther H, Köhler E (1979). "[Human pharmacologic studies on the biologic availability and resorption of cafaminol (AWD) (proceedings)]". Pharmazie (in German). 34 (5–6): 375–6. PMID 515164.
Rogowski M, Chodynicki S (1985). "[Use of the preparation Cafaminol in the treatment of acute rhinitis]". Wiad. Lek. (in Polish). 38 (20): 1437–40. PMID 3913153.

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[Elks2014-1] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 205–. ISBN 978-1-4757-2085-3.

[IndexNominum2000-2] Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 157–. ISBN 978-3-88763-075-1.

[Publishing2013-3] William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia. Elsevier. pp. 784–. ISBN 978-0-8155-1856-3.

[pmid5818666-4] Szirmai E (1969). "[A new treatment for colds using a new caffeine derivative, methylcoffanolamine]". Praxis (in German). 58 (13): 412–4. PMID 5818666.

[pmid515164-5] Walther H, Köhler E (1979). "[Human pharmacologic studies on the biologic availability and resorption of cafaminol (AWD) (proceedings)]". Pharmazie (in German). 34 (5–6): 375–6. PMID 515164.

[pmid3913153-6] Rogowski M, Chodynicki S (1985). "[Use of the preparation Cafaminol in the treatment of acute rhinitis]". Wiad. Lek. (in Polish). 38 (20): 1437–40. PMID 3913153.