Thonzylamine

Thonzylamine (or neohetramine)[1] is an antihistamine and anticholinergic used as an antipruritic.

Thonzylamine
Clinical data
Other namesNeohetramine
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyrimidin-2-ylethane-1,2-diamine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.001.913
Chemical and physical data
FormulaC16H22N4O
Molar mass286.379 g·mol−1
3D model (JSmol)
SMILES
  • n1cccnc1N(CCN(C)C)Cc2ccc(OC)cc2
InChI
  • InChI=1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3 Y
  • Key:GULNIHOSWFYMRN-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

Synthesis
Thonzylamine synthesis: H. L. Friedman and A, V. Tolstouhov, U.S. Patent 2,465,865 (1949).

See also

References
  1. Arminio JJ, Sweet CC (December 1949). "The prophylaxis and treatment of the common cold with neohetramine (thonzylamine hydrochloride)". Industrial Medicine & Surgery. 18 (12): 509–11. PMID 15393969.
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