Bamipine

Bamipine (trade name Soventol)[1] is a pharmaceutical drug acting as an H1 antihistamine with anticholinergic properties.[2] It is used as an antipruritic ointment.[3] No oral use is known.[4]

Bamipine
Clinical data
Trade namesSoventol
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral?, topical
ATC code
Identifiers
IUPAC name
  • N-benzyl-1-methyl-N-phenyl-piperidin-4-amine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.023.261
Chemical and physical data
FormulaC19H24N2
Molar mass280.415 g·mol−1
3D model (JSmol)
SMILES
  • N(c1ccccc1)(Cc2ccccc2)C3CCN(C)CC3
InChI
  • InChI=1S/C19H24N2/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-11,19H,12-16H2,1H3 Y
  • Key:VZSXTYKGYWISGQ-UHFFFAOYSA-N Y
  (verify)

Adverse effects

Side effects are typical of an old (first-generation) antihistamine: tiredness in adults, agitation in children, mydriasis (dilation of the pupils). These effects are rare when bamipine is applied topically as an ointment. Allergic and hypersensitivity reactions are also rare. Acute eczema can be worsened by bamipine ointment.[5]

Contraindications and interactions

No clinically relevant contraindications or interactions with other drugs are known.[5]

Pharmacology

Pharmacokinetics

When applied topically, the maximal effect is reached after 20 to 60 minutes and lasts up to 48 hours. Bamipine is not absorbed through intact skin in relevant doses.[5]

References
  1. Publishing, William Andrew (2013-10-22). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. p. 523. ISBN 978-0-8155-1856-3.
  2. Vardanyan RS (2017). "Chapter 5: 4-Substituted and 1,4-Disubstituted Piperidines". Piperidine-based drug discovery. Amsterdam, Netherlands. p. 191. ISBN 978-0-12-813428-3.
  3. WO 0236163, Pairet M, Pieper MP, Meade CJ, Schmelzer C, "Pharmaceutical compositions containing tiotropium salts and antihistamines and their use", published 10 May 2002, assigned to Boehringer Ingelheim
  4. International Drug Names: Bamipine.
  5. Haberfeld H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Soventol-Gel.
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