Camylofin

Camylofin
Clinical data
Other names	Acamylophenine
AHFS/Drugs.com	International Drug Names
ATC code	A03AA03 (WHO) ;
Identifiers
	IUPAC name Isopentyl 2-[2-(diethylamino)ethylamino]-2-phenylacetate;
CAS Number	54-30-8 ;
PubChem CID	5902;
ChemSpider	5691 ;
UNII	340B6Q764V;
ChEMBL	ChEMBL253592 ;
CompTox Dashboard (EPA)	DTXSID7046415 ;
ECHA InfoCard	100.000.184
Chemical and physical data
Formula	C19H32N2O2
Molar mass	320.477 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCCC(C)C)C(NCCN(CC)CC)c1ccccc1;
	InChI InChI=1S/C19H32N2O2/c1-5-21(6-2)14-13-20-18(17-10-8-7-9-11-17)19(22)23-15-12-16(3)4/h7-11,16,18,20H,5-6,12-15H2,1-4H3 ; Key:RYOOHIUJEJZCFT-UHFFFAOYSA-N ;
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Camylofin is an antimuscarinic drug.[1]

Camylofin is a smooth muscle relaxant with both anticholinergic action as well as direct smooth muscle action. Anticholinergic action is produced by inhibiting the binding of acetylcholine to muscarinic receptors, but the action is less pronounced. Direct smooth muscle relaxation is achieved by inhibiting phosphodiesterase type IV, which leads to increased cyclic AMP and eventually reduced cytosolic calcium. Thus camylofin has a comprehensive action to relieve smooth muscle spasm. It is used to treat stomach ache in infants and children. Usually it is given in combination with paracetamol to treat stomach ache, as well as pyrexia.[2]

References

"Camylofin". PubChem. Retrieved 2019-06-02.
Sarbhjit K, Bajwa SK, Parmjit K, Surinder B (September 2013). "To compare the effect of camylofin dihydrochloride (anafortin) with combination of valethamate bromide (epidosin) and hyoscine butyl-N-bormide (buscopan) on cervical dilation". Journal of Clinical and Diagnostic Research. 7 (9): 1897–9. doi:10.7860/JCDR/2013/6231.3345. PMC 3809631. PMID 24179892.

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[1] "Camylofin". PubChem. Retrieved 2019-06-02.

[2] Sarbhjit K, Bajwa SK, Parmjit K, Surinder B (September 2013). "To compare the effect of camylofin dihydrochloride (anafortin) with combination of valethamate bromide (epidosin) and hyoscine butyl-N-bormide (buscopan) on cervical dilation". Journal of Clinical and Diagnostic Research. 7 (9): 1897–9. doi:10.7860/JCDR/2013/6231.3345. PMC 3809631. PMID 24179892.