EA-3834

EA-3834 is a potent anticholinergic deliriant drug with a fairly long duration of action, related to the chemical warfare agent 3-quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.

EA-3834
Identifiers
IUPAC name
  • (1-methylpiperidin-4-yl) 2-hydroxy-3-methyl-2-phenylbutanoate
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC17H25NO3
Molar mass291.391 g·mol−1
3D model (JSmol)
SMILES
  • C1CN(C)CCC1OC(=O)C(O)(C(C)C)c2ccccc2
InChI
  • InChI=1S/C17H25NO3/c1-13(2)17(20,14-7-5-4-6-8-14)16(19)21-15-9-11-18(3)12-10-15/h4-8,13,15,20H,9-12H2,1-3H3
  • Key:IFXNWEDGILPSBA-UHFFFAOYSA-N
  (verify)

EA-3834 has a potency and central to peripheral effects ratio only slightly less than that of related compounds such as EA-3443, and is faster acting and shorter lasting, although not as much as other compounds such as 302196.[1][2]

EA-3834 appears to cause renal problems, among them, microhematuria.[3]

See also

References
  1. Commission on Life Sciences (1982). "N-Methyl-4-piperidinyl-(phenylisopropyl)-glycolate (EA 3834)". Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. Vol. 1. The National Academies Press. pp. 200–204.
  2. Ketchum JS (2006). Chemical Warfare Secrets Almost Forgotten. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War. ChemBooks Inc. ISBN 978-1-4243-0080-8.
  3. Khatchadourian, Raffi (December 9, 2012). "Operation Delirium". newyorker.com. Retrieved May 18, 2021. Another version [of BZ], called EA 3834, appeared to cause microscopic hematuria—tiny amounts of blood in urine—and other renal problems.


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