CAR-301,060

CAR-301,060 (also known as cis-2-Methyl-3-quinuclidinylphenylcyclopentylglycolate or just by its code number 301060) is a potent and long lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.

CAR-301,060
Identifiers
IUPAC name
  • [(7R,8R)-7-methyl-1-azabicyclo[2.2.2]octan-8-yl]2-cyclopentyl-2-hydroxy-2-phenylacetate
PubChem CID
Chemical and physical data
FormulaC21H29NO3
Molar mass343.467 g·mol−1
3D model (JSmol)
SMILES
  • C[C@@H]1[C@@H](C2CCN1CC2)OC(=O)C(C3CCCC3)(C4=CC=CC=C4)O
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CAR-301,060 was found to be slightly less potent than QNB, and with around the same duration of action, but with a very high central to peripheral effects ratio.[1][2]

See also

References
  1. Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. Commission on Life Sciences. Vol. 1. The National Academies Press. 1982. pp. 199–200.
  2. Ketchum JS (2006). Chemical Warfare Secrets Almost Forgotten. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War. ChemBooks Inc. ISBN 978-1-4243-0080-8.


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