Propiverine

Propiverine is an anticholinergic drug used for the treatment of urinary urgency, frequency and urge incontinence, all symptoms of overactive bladder syndrome.[1][2] It is a muscarinic antagonist.[3] A modified release preparation is also available, taken once daily.

Propiverine
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Pharmacokinetic data
Elimination half-life20.1 h
Identifiers
IUPAC name
  • 1-methylpiperidin-4-yl diphenyl(propoxy)acetate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC23H29NO3
Molar mass367.489 g·mol−1
3D model (JSmol)
SMILES
  • CCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OC3CCN(CC3)C
InChI
  • InChI=1S/C23H29NO3/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21/h4-13,21H,3,14-18H2,1-2H3 N
  • Key:QPCVHQBVMYCJOM-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

References
  1. McKeage K (January 2013). "Propiverine: a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity, and in men with lower urinary tract symptoms". Clinical Drug Investigation. 33 (1): 71–91. doi:10.1007/s40261-012-0046-9. PMID 23288694.
  2. Huang W, Zong H, Zhou X, Wang T, Zhang Y (December 2015). "Efficacy and Safety of Propiverine Hydrochloride for Overactive Bladder in Adult: a Systematic Review and Meta-analysis". The Indian Journal of Surgery. 77 (Suppl 3): 1369–1377. doi:10.1007/s12262-015-1264-1. PMC 4775592. PMID 27011567.
  3. BNF 61. London: British Medical Journal Group and Pharmaceutical Press. March 2011. p. 511. ISBN 978-0-85369-962-0.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.