AM-2232

AM-2232 (1-(4-cyanobutyl)-3-(naphthalen-1-oyl)indole) is a drug that acts as a potent but unselective agonist for the cannabinoid receptors, with a Ki of 0.28 nM at CB1 and 1.48 nM at CB2.[1]

AM-2232
Legal status
Legal status
  • CA: Schedule II
  • DE: Anlage II (Authorized trade only, not prescriptible)
  • NZ: Temporary Class
  • UK: Class B
  • US: Schedule I
Identifiers
IUPAC name
  • 5-(3-(1-Naphthoyl)-1H-indol-1-yl)pentanenitrile
CAS Number
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H20N2O
Molar mass352.437 g·mol−1
3D model (JSmol)
SMILES
  • c1ccc2c(c1)cccc2C(=O)c3cn(c4c3cccc4)CCCCC#N
InChI
  • InChI=1S/C24H20N2O/c25-15-6-1-7-16-26-17-22(20-12-4-5-14-23(20)26)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17H,1,6-7,16H2 N
  • Key:VWVAIBKHFCUSMD-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as AM-2232 are Schedule I Controlled Substances.[2]

See also

References
  1. US patent 7241799, Makriyannis A, Deng H, "Cannabimimetic indole derivatives", granted 2007-07-10
  2. 21 U.S.C. § 812: Schedules of controlled substances


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