RH-34

RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT2A affinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.[1][2][3]

RH-34
Clinical data
Routes of
administration
?
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
IUPAC name
  • 3-[2-(2-methoxybenzylamino)ethyl]-1H-quinazoline-2,4-dione
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H19N3O3
Molar mass325.368 g·mol−1
3D model (JSmol)
SMILES
  • O=c1[nH]c2ccccc2c(=O)n1CCNCc3ccccc3OC
InChI
  • InChI=1S/C18H19N3O3/c1-24-16-9-5-2-6-13(16)12-19-10-11-21-17(22)14-7-3-4-8-15(14)20-18(21)23/h2-9,19H,10-12H2,1H3,(H,20,23) N
  • Key:NUAJBITWGGTZCM-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

RH-34 is a controlled substance in Hungary[4] and Brazil.[5]

See also

References

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