Avitriptan

Avitriptan (INN) (code name BMS-180,048) is an antimigraine drug of the triptan family which was never marketed.[1] It acts as a 5-HT1B and 5-HT1D receptor agonist.[1]

Avitriptan
Clinical data
ATC code
  • none
Legal status
Legal status
  • Never marketed
Identifiers
IUPAC name
  • 1-[3-[3-[4-(5-methoxypyrimidin-4-yl)piperazin-1-yl]propyl]-1H-indol-5-yl]-N-methyl-methanesulfonamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H30N6O3S
Molar mass458.58 g·mol−1
3D model (JSmol)
SMILES
  • O=S(=O)(NC)Cc1ccc2c(c1)c(c[nH]2)CCCN4CCN(c3ncncc3OC)CC4
InChI
  • InChI=1S/C22H30N6O3S/c1-23-32(29,30)15-17-5-6-20-19(12-17)18(13-25-20)4-3-7-27-8-10-28(11-9-27)22-21(31-2)14-24-16-26-22/h5-6,12-14,16,23,25H,3-4,7-11,15H2,1-2H3 Y
  • Key:WRZVGHXUPBWIOO-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

See also

References
  1. Saxena PR, De Vries P, Wang W, et al. (February 1997). "Effects of avitriptan, a new 5-HT 1B/1D receptor agonist, in experimental models predictive of antimigraine activity and coronary side-effect potential". Naunyn-Schmiedeberg's Archives of Pharmacology. 355 (2): 295–302. doi:10.1007/pl00004946. hdl:1765/66501. PMID 9050026. S2CID 25137165. Archived from the original on 1999-10-23.


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