CGS-12066A

CGS-12066A is a drug which acts as a potent and selective agonist for the 5-HT1B receptor with lower affinity for the three 5-HT2 receptor subtypes.[1][2] It is used for studying the role of the 5-HT1B receptor in various processes including perception of pain and the sleep-wake cycle.[3][4]

CGS-12066A
Identifiers
IUPAC name
  • 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H17F3N4
Molar mass334.346 g·mol−1
3D model (JSmol)
SMILES
  • C3CN(C)CCN3c2nc1cc(C(F)(F)F)ccc1n4cccc24
InChI
  • InChI=1S/C17H17F3N4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16/h2-6,11H,7-10H2,1H3 N
  • Key:LXFHSCDLMBZYKY-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

References
  1. Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (August 2004). "Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors". Naunyn-Schmiedeberg's Archives of Pharmacology. 370 (2): 114–23. doi:10.1007/s00210-004-0951-4. PMID 15322733. S2CID 8938111.
  2. Jeong HS, Jang MJ, Park JS (March 2005). "Effects of CGS-12066A on medial vestibular nuclear neurons". Brain Research. 1038 (1): 118–21. doi:10.1016/j.brainres.2005.01.025. PMID 15748881. S2CID 22734919.
  3. Monti JM, Jantos H (2008). "The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking". Progress in Brain Research. 172: 625–46. doi:10.1016/S0079-6123(08)00929-1. ISBN 9780444532350. PMID 18772053.
  4. Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM (January 2010). "The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats". Neuroscience. 165 (2): 561–8. doi:10.1016/j.neuroscience.2009.10.020. PMID 19837141. S2CID 195684404.
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