Iodocyanopindolol

Iodocyanopindolol (INN) is a drug related to pindolol which acts as both a β1 adrenoreceptor antagonist and a 5-HT1A receptor antagonist. Its 125I radiolabelled derivative has been widely used in mapping the distribution of beta adrenoreceptors in the body.[1]

Iodocyanopindolol
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • (RS)-4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3-iodo-1H-indole-2-carbonitrile
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H20IN3O2
Molar mass413.259 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
SMILES
  • IC1=C(C#N)NC2=CC=CC(OCC(CNC(C)(C)C)O)=C21
InChI
  • InChI=1S/C16H20IN3O2/c1-16(2,3)19-8-10(21)9-22-13-6-4-5-11-14(13)15(17)12(7-18)20-11/h4-6,10,19-21H,8-9H2,1-3H3
  • Key:JBLUMBNIBNHRSO-UHFFFAOYSA-N
 NY (what is this?)  (verify)

References
  1. Brodde OE, Karad K, Zerkowski HR, Rohm N, Reidemeister JC (1983). "Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding". Circulation Research. 53 (6): 752–758. doi:10.1161/01.res.53.6.752. PMID 6139182.



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