Phendioxan

Phendioxan is an α1-adrenergic receptor antagonist.[1]

Phendioxan
Names
Preferred IUPAC name
2-(2,6-Dimethoxyphenoxy)-N-{[(2R,3R)-3-phenyl-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}ethan-1-amine
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
UNII
InChI
  • InChI=1S/C25H27NO5/c1-27-21-13-8-14-22(28-2)25(21)29-16-15-26-17-23-24(18-9-4-3-5-10-18)31-20-12-7-6-11-19(20)30-23/h3-14,23-24,26H,15-17H2,1-2H3/t23-,24-/m1/s1
    Key: UVEKKXRFQCNLQE-DNQXCXABSA-N
  • InChI=1/C25H27NO5/c1-27-21-13-8-14-22(28-2)25(21)29-16-15-26-17-23-24(18-9-4-3-5-10-18)31-20-12-7-6-11-19(20)30-23/h3-14,23-24,26H,15-17H2,1-2H3/t23-,24-/m1/s1
    Key: UVEKKXRFQCNLQE-DNQXCXABBD
SMILES
  • COC1=C(C(=CC=C1)OC)OCCNC[C@@H]2[C@H](OC3=CC=CC=C3O2)C4=CC=CC=C4
Properties
Chemical formula
 C25H27NO5
Molar mass 421.493 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also

References
  1. Quaglia, W; Pigini, M; Tayebati, SK; Piergentili, A; Giannella, M; Marucci, G; Melchiorre, C (1993). "Structure-activity relationships in 1,4-benzodioxan-related compounds. 4. Effect of aryl and alkyl substituents at position 3 on alpha-adrenoreceptor blocking activity". Journal of Medicinal Chemistry. 36 (11): 1520–8. doi:10.1021/jm00063a002. PMID 8098772.



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