Cetamolol

Cetamolol is a beta adrenergic antagonist, more specifically a β1-adrenergic blocker.[1]

Cetamolol
Names
IUPAC name
2-[2-[3-(tert-Butylamino)-2-hydroxypropoxy]phenoxy]-N-methylacetamide
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
KEGG
PubChem CID
UNII
InChI
  • InChI=1S/C16H26N2O4/c1-16(2,3)18-9-12(19)10-21-13-7-5-6-8-14(13)22-11-15(20)17-4/h5-8,12,18-19H,9-11H2,1-4H3,(H,17,20)
    Key: UWCBNAVPISMFJZ-UHFFFAOYSA-N
SMILES
  • CC(C)(C)NCC(COC1=CC=CC=C1OCC(=O)NC)O
Properties
Chemical formula
 C16H26N2O4
Molar mass 310.394 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Synthesis
Cetamolol synthesis:[2][3]

References
  1. Klausner, MA; Irwin, C; Mullane, JF; Shand, DG; Leese, PT; Arnold, JD; Wollberg, W; Wagner, NB; Wagner, GS (1988). "Effect of cetamolol on epinephrine-induced hypokalemia". Journal of Clinical Pharmacology. 28 (8): 751–6. doi:10.1002/j.1552-4604.1988.tb03210.x. PMID 2905711. S2CID 30767741.
  2. HL Tucker, DE 2453324 (1975) via Chem. Abstr., 83:96,993p
  3. BE 767781; D. J. Lecount, C. J. Squire, U.S. Patent 4,059,622 (1971, 1977 both to ICI).


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