L-694247

L-694247 is a somewhat selective 5-HT1D agonist, with a 10-fold greater affinity for the 5-HT1B receptor, and 25-fold greater affinity for the 5-HT1A receptor.[1] When L-694247 was injected intraventricularly in dehydrated rats, it inhibited water intake. Pre-treatment with a 5-HT1D antagonist abolished this effect. Administration of L-694,247 to normally hydrated rats had no effect on water intake.[2]

L-694247
Names
Preferred IUPAC name
N-[4-({5-[3-(2-Aminoethyl)-1H-indol-5-yl]-1,2,4-oxadiazol-3-yl}methyl)phenyl]methanesulfonamide
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
PubChem CID
InChI
  • InChI=1S/C20H21N5O3S/c1-29(26,27)25-16-5-2-13(3-6-16)10-19-23-20(28-24-19)14-4-7-18-17(11-14)15(8-9-21)12-22-18/h2-7,11-12,22,25H,8-10,21H2,1H3
    Key: HKXMQLISPYELRD-UHFFFAOYSA-N
SMILES
  • CS(=O)(=O)Nc1ccc(cc1)Cc2nc(on2)c3ccc4c(c3)c(c[nH]4)CCN
Properties
Chemical formula
 C20H21N5O3S
Molar mass 411.48 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. Beer, MS (November 1993). "L-694,247: a potent 5-HT1D receptor agonist". British Journal of Pharmacology. 110 (3): 1196–200. doi:10.1111/j.1476-5381.1993.tb13941.x. PMC 2175804. PMID 8298808.
  2. CASTRO-e-SILVA, E. DE (August 1997). "Effect of Third Ventricle Administration of L-694,247, a Selective 5-HT1D Receptor Agonist, on Water Intake in Rats". Pharmacology Biochemistry and Behavior. 57 (4): 749–754. doi:10.1016/S0091-3057(96)00457-1. PMID 9259002. S2CID 32511102.
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