AS-19 (drug)

AS-19 is a substance which acts as a potent agonist at the 5-HT7 receptor, with an IC50 of 0.83nM. It reverses the amnesia induced by drugs such as scopolamine and dizocilpine and improves long-term memory acquisition, but inhibits short-term memory formation.[1][2]

AS-19
Identifiers
IUPAC name
  • (2S)-N,N-dimethyl-5-(1,3,5-trimethylpyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC18H25N3
Molar mass283.419 g·mol−1
3D model (JSmol)
SMILES
  • CC1=C(C(=NN1C)C)C2=C3CC[C@@H](CC3=CC=C2)N(C)C
InChI
  • InChI=1S/C18H25N3/c1-12-18(13(2)21(5)19-12)17-8-6-7-14-11-15(20(3)4)9-10-16(14)17/h6-8,15H,9-11H2,1-5H3/t15-/m0/s1 Y
  • Key:BTTOYOKCLDAHHO-HNNXBMFYSA-N Y
  (verify)

See also

References
  1. Meneses A, Perez-Garcia G, Liy-Salmeron G, Flores-Galvez D, Castillo C, Castillo E (December 2008). "The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation". Behavioural Brain Research. 195 (1): 112–9. doi:10.1016/j.bbr.2007.11.023. PMID 18191236. S2CID 144901859.
  2. Perez-García G, Meneses A (December 2008). "Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia". Behavioural Brain Research. 195 (1): 139–46. doi:10.1016/j.bbr.2008.07.033. PMID 18723050. S2CID 140204255.
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