UH-301

(S)-UH-301 is a drug and research chemical widely used in scientific studies. It acts as a selective 5-HT1A receptor silent antagonist.[1] It is structurally related to 8-OH-DPAT.[1] UH-301 was found to produce a head-twitch response in mice which is usually typical of 5-HT2A agonist drugs, and has subsequently been used to investigate how 5-HT1A receptor activity modulates 5-HT2A receptors downstream.[2]

UH-301
Identifiers
IUPAC name
  • (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin
CAS Number
IUPHAR/BPS
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H24FNO
Molar mass265.372 g·mol−1
3D model (JSmol)
SMILES
  • C2Cc1c(c(O)ccc1F)CC2N(CCC)CCC
  (verify)

See also

References
  1. Björk L, Cornfield LJ, Nelson DL, Hillver SE, Andén NE, Lewander T, Hacksell U (1991). "Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects". J Pharmacol Exp Ther. 258 (1): 58–65. PMID 1830099.
  2. Darmani, N. A.; Reeves, S. L. (1996). "The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice". Pharmacology Biochemistry and Behavior. 55 (1): 1–10. doi:10.1016/0091-3057(96)00072-X. PMID 8870031. S2CID 25607128.


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