para-Chlorophenylpiperazine

para-Chlorophenylpiperazine (pCPP) is a psychoactive drug of the phenylpiperazine class.[1] It is relatively obscure, with limited human use, and produces slightly psychedelic effects. It has been encountered in illicit capsules as a recreational drug similarly to other piperazines like mCPP.[1] Scientific research has demonstrated pCPP to have serotonergic effects, likely acting as a non-selective serotonin receptor agonist and/or releasing agent.[2][3]

para-Chlorophenylpiperazine
Clinical data
Routes of
administration		Oral
ATC code
  • none
Identifiers
IUPAC name
  • 1-(4-chlorophenyl)piperazine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.155.613
Chemical and physical data
FormulaC10H13ClN2
Molar mass196.68 g·mol−1
3D model (JSmol)
SMILES
  • Clc1ccc(cc1)N2CCNCC2

A known use has been in the synthesis of L-745,870.

See also

References
  1. "www.emcdda.europa.eu" (PDF).
  2. Fuller RW, Snoddy HD (July 1980). "Comparative effects of p-chloroamphetamine and 1-(p-chlorophenyl)piperazine on 5-hydroxyindole concentration in rat brain". Research Communications in Chemical Pathology and Pharmacology. 29 (1): 201–4. PMID 6157183.
  3. Maj J, Lewandowska A (1980). "Central serotoninmimetic action of phenylpiperazines". Polish Journal of Pharmacology and Pharmacy. 32 (4): 495–504. PMID 7255267.
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