para-Bromoamphetamine

para-Bromoamphetamine (PBA), also known as 4-bromoamphetamine (4-BA), is an amphetamine derivative which acts as a serotonin-norepinephrine-dopamine releasing agent (SNDRA) and produces stimulant effects.

para-Bromoamphetamine
Clinical data
ATC code
  • none
Legal status
Legal status
  • DE: NpSG (Industrial and scientific use only)
  • UK: Class A
Identifiers
IUPAC name
  • 1-(4-bromophenyl)propan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC9H12BrN
Molar mass214.106 g·mol−1
3D model (JSmol)
SMILES
  • Brc1ccc(cc1)CC(N)C
InChI
  • InChI=1S/C9H12BrN/c1-7(11)6-8-2-4-9(10)5-3-8/h2-5,7H,6,11H2,1H3 Y
  • Key:SMNXUMMCCOZPPN-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

Another related compound is para-bromomethamphetamine known by the codename V-111.[1]

Neurotoxicity

Like most other para-substituted amphetamines, PBA can be neurotoxic and may deplete the brain of 5-hydroxyindoles for at least a week.[2]

See also

References
  1. Magyar K, Tekes K, Zólyomi G, Szüts T, Knoll J. The fate of p-bromo-methylamphetamine (V-111) in the body. Acta Physiol Acad Sci Hung. 1981;57(3):285-307. PMID: 7304194.
  2. Fuller RW, Baker JC, Perry KW, Molloy BB (October 1975). "Comparison of 4-chloro-, 4-bromo- and 4-fluoroamphetamine in rats: drug levels in brain and effects on brain serotonin metabolism". Neuropharmacology. 14 (10): 739–46. doi:10.1016/0028-3908(75)90099-4. PMID 1196472. S2CID 9620299.
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