Mefenorex

Mefenorex (Rondimen, Pondinil, Anexate) is a stimulant drug which was used as an appetite suppressant. It is an amphetamine derivative which was developed in the 1970s and used for the treatment of obesity.[1][2] Mefenorex produces amphetamine as a metabolite,[3] and has been withdrawn in many countries despite having only mild stimulant effects and relatively little abuse potential.[4]

Mefenorex
Clinical data
Trade namesRondimen, Pondinil, Anexate
ATC code
Legal status
Legal status
  • CA: Schedule I
  • DE: Anlage II (Authorized trade only, not prescriptible)
Identifiers
IUPAC name
  • 3-chloro-N-(1-methyl-2-phenylethyl)propan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.037.511
Chemical and physical data
FormulaC12H18ClN
Molar mass211.73 g·mol−1
3D model (JSmol)
SMILES
  • ClCCCNC(Cc1ccccc1)C
InChI
  • InChI=1S/C12H18ClN/c1-11(14-9-5-8-13)10-12-6-3-2-4-7-12/h2-4,6-7,11,14H,5,8-10H2,1H3 Y
  • Key:XXVROGAVTTXONC-UHFFFAOYSA-N Y
  (verify)

References
  1. Vincendeau MJ (1970). "[A new regulator of appetite: mefenorex]". Bordeaux Medical (in French). 3 (7): 1951–3. PMID 5455004.
  2. Beyer G, Huth K, Müller GM, Niemöller H, Raisp I, Vorberg G (February 1980). "[The treatment of obesity with the appetite curbing agent Mefenorex]". Die Medizinische Welt (in German). 31 (8): 306–9. PMID 7374423.
  3. Rendić S, Slavica M, Medić-Sarić M (1994). "Urinary excretion and metabolism of orally administered mefenorex". European Journal of Drug Metabolism and Pharmacokinetics. 19 (2): 107–17. doi:10.1007/BF03188831. PMID 8001591. S2CID 7170057.
  4. Engel J, Kristen G, Schaefer A, von Schlichtegroll A (June 1986). "Mefenorex (Rondimen)". Drug and Alcohol Dependence. 17 (2–3): 229–34. doi:10.1016/0376-8716(86)90010-4. PMID 3743406.


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