PNU-120,596

PNU-120596 is a drug that acts as a potent and selective positive allosteric modulator for the α7 subtype of neural nicotinic acetylcholine receptors.[1][2] It is used in scientific research into cholinergic regulation of dopamine and glutamate release in the brain.[3][4][5]

PNU-120,596
Identifiers
IUPAC name
  • 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H14ClN3O4
Molar mass311.720 g·mol−1
3D model (JSmol)
SMILES
  • COc1cc(OC)c(Cl)cc1NC(=O)Nc2noc(C)c2
InChI
  • InChI=1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18) N
  • Key:CEIIEALEIHQDBX-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

References
  1. Hurst RS, Hajós M, Raggenbass M, Wall TM, Higdon NR, Lawson JA, et al. (April 2005). "A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization". The Journal of Neuroscience. 25 (17): 4396–405. doi:10.1523/JNEUROSCI.5269-04.2005. PMC 6725110. PMID 15858066.
  2. Young GT, Zwart R, Walker AS, Sher E, Millar NS (September 2008). "Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site". Proceedings of the National Academy of Sciences of the United States of America. 105 (38): 14686–91. Bibcode:2008PNAS..10514686Y. doi:10.1073/pnas.0804372105. PMC 2535569. PMID 18791069.
  3. Livingstone PD, Srinivasan J, Kew JN, Dawson LA, Gotti C, Moretti M, et al. (February 2009). "alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortex". The European Journal of Neuroscience. 29 (3): 539–50. doi:10.1111/j.1460-9568.2009.06613.x. PMID 19187266. S2CID 13289370.
  4. Barron SC, McLaughlin JT, See JA, Richards VL, Rosenberg RL (August 2009). "An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine". Molecular Pharmacology. 76 (2): 253–63. doi:10.1124/mol.109.056226. PMC 2713121. PMID 19411608.
  5. Livingstone PD, Dickinson JA, Srinivasan J, Kew JN, Wonnacott S (January 2010). "Glutamate-dopamine crosstalk in the rat prefrontal cortex is modulated by Alpha7 nicotinic receptors and potentiated by PNU-120596". Journal of Molecular Neuroscience. 40 (1–2): 172–6. doi:10.1007/s12031-009-9232-5. PMID 19688191. S2CID 29929913.


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