Pholedrine

Pholedrine (Paredrinol, Pulsotyl, Veritol), also known as 4-hydroxy-N-methylamphetamine (4-HMA), 4-hydroxymethamphetamine, and para-hydroxymethamphetamine,[1] is a drug that stimulates the sympathetic nervous system.[2] It is administered as a topical eye drop form for the purpose of dilating the pupil and can be used to diagnose Horner's syndrome.[2]

Metabolic pathways of methamphetamine
4-Hydroxyphenylacetone
Phenylacetone
Benzoic acid
Hippuric acid
Pholedrine is one of methamphetamine's active metabolites in humans.
Pholedrine
Clinical data
Routes of
administration		Topical (Ocular)
Identifiers
IUPAC name
  • 4-[2-(Methylamino)propyl]phenol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.006.114
Chemical and physical data
FormulaC10H15NO
Molar mass165.236 g·mol−1
3D model (JSmol)
SMILES
  • Oc1ccc(cc1)CC(NC)C
InChI
  • InChI=1S/C10H15NO/c1-8(11-2)7-9-3-5-10(12)6-4-9/h3-6,8,11-12H,7H2,1-2H3 N
  • Key:SBUQZKJEOOQSBV-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

See also

References
  1. P-HYDROXYMETHAMPHETAMINE CAS#: 370-14-9
  2. Bates AT, Chamberlain S, Champion M, Foley L, Hughes E, Jani B, et al. (February 1995). "Pholedrine: a substitute for hydroxyamphetamine as a diagnostic eyedrop test in Horner's syndrome". Journal of Neurology, Neurosurgery, and Psychiatry. 58 (2): 215–7. doi:10.1136/jnnp.58.2.215. PMC 1073320. PMID 7876854.
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