Hexacyclonate

Hexacyclonate (Gevilon) is a stimulant drug. It has been used for the treatment of alcoholism[1] and for increasing motivation in elderly patients,[2] but is now mainly used for the treatment of hyperlipoproteinaemia.[3][4] It is chemically similar to the anticonvulsant gabapentin, with a hydroxyl group replacing the amine.

Hexacyclonate
Identifiers
IUPAC name
  • [1-(hydroxymethyl)cyclohexyl]acetic acid
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC9H16O3
Molar mass172.222 g·mol−1
3D model (JSmol)
SMILES
  • O=C(O)CC1(CO)CCCCC1
InChI
  • InChI=1S/C9H16O3/c10-7-9(6-8(11)12)4-2-1-3-5-9/h10H,1-7H2,(H,11,12) Y
  • Key:WMJPAYUKEVEBCN-UHFFFAOYSA-N Y
  (verify)

The latter use may be incorrectly assigned, as "Gevilon" has been used as a trade name for gemfibrozil, a well-known drug for dislypidemia.

References
  1. Chesrow EJ, Sabatini R, Musci JP, Kaplitz SE, Marquardt GH (May 1962). "Adjunctive treatment of the chronic alcoholic with hexacyclonate sodium". The Illinois Medical Journal. 121: 546–8. PMID 13878809.
  2. Morrison BO (January 1962). "Pharmaco-motivation of the geriatric patient: a preliminary report on hexacyclonate". The Journal of the Louisiana State Medical Society. 114: 23–6. PMID 14476295.
  3. Milewicz A, Plamieniak Z, Bohdanowicz-Pawlak A (1992). "Therapeutic effect of gevilon in patients with hyperlipoproteinaemia". Materia Medica Polona. Polish Journal of Medicine and Pharmacy. 24 (2): 91–5. PMID 1307777.
  4. Gazdikova K, Korecka P, Springer V, Gazdik F (2003). "Pharmacoeconomic aspects of patients treated by hemodialysis". Bratislavske Lekarske Listy. 104 (10): 329–34. PMID 15055734.
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