Pentylone

Pentylone (β-Keto-Methyl​benzo​dioxolyl​pentanamine, βk-Methyl-K, βk-MBDP, methyl​enedioxy​pentedrone, or 1‐(3,4‐methylenedioxyphenyl)‐2‐(methylamino)pentan‐1‐one[1]) is a stimulant developed in the 1960s.[2] It is a substituted cathinone (a type of substituted phenethylamine). It has been identified in some samples of powders sold as "NRG-1", along with varying blends of other cathinone derivatives including flephedrone, MDPBP, MDPV and 4-MePPP. It was also found in combination with 4-MePPP being sold as "NRG-3".[1] Reports indicate side effects include feelings of paranoia, agitation and inability to sleep, with effects lasting for several days at high doses.[3]

Pentylone
Clinical data
ATC code
  • none
Legal status
Legal status
  • DE: Anlage I (Authorized scientific use only)
  • UK: Class B
  • US: Schedule I
  • Illegal in Sweden
Identifiers
IUPAC name
  • (±)-1-(1,3-benzodioxol-5-yl)-2-(methylamino)pentan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H17NO3
Molar mass235.283 g·mol−1
3D model (JSmol)
SMILES
  • c2cc1OCOc1cc2C(=O)C(NC)CCC
InChI
  • InChI=1S/C13H17NO3/c1-3-4-10(14-2)13(15)9-5-6-11-12(7-9)17-8-16-11/h5-7,10,14H,3-4,8H2,1-2H3 N
  • Key:DFMLULIEUUXXSA-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

Pharmacology

Pentylone acts as a serotonin-norepinephrine-dopamine reuptake inhibitor and a serotonin releasing agent.[4]

Legality

Pentylone is banned in Canada, Germany, Sweden, the United States and in the UK.[5][6]

See also

References
  1. Brandt SD, Freeman S, Sumnall HR, Measham F, Cole J (December 2010). "Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones". Drug Testing and Analysis. 3 (9): 569–75. doi:10.1002/dta.204. PMID 21960541.
  2. Substituted phenyl-α-amino ketones. British Patent GB 1085135 (1969).
  3. Joe Bish (Aug 4, 2017). "Watch Out for Pentylone, the Horrible New MDMA Additive". Vice.
  4. Simmler, L. D.; Rickli, A.; Hoener, M. C.; Liechti, M. E. (2014). "Monoamine transporter and receptor interaction profiles of a new series of designer cathinones". Neuropharmacology. 79: 152–60. doi:10.1016/j.neuropharm.2013.11.008. PMID 24275046. S2CID 25259854.
  5. "Cannabinoider föreslås bli klassade som hälsofarlig vara" (in Swedish). Retrieved 29 June 2015.
  6. Schedules of Controlled Substances: Temporary Placement of 10 Synthetic Cathinones Into Schedule I
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