Methamnetamine

Methamnetamine (also known as methylnaphetamine, MNA, MNT and PAL-1046) is a triple monoamine releasing agent and N-methyl analog of the non-neurotoxic experimental drug naphthylaminopropane and the naphthalene analog of methamphetamine.[1][2][3] It has been sold online as a designer drug.[4][5]

Methamnetamine
Legal status
Legal status
Identifiers
IUPAC name
  • N-Methyl-1-(naphthalen-2-yl)propan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC14H17N
Molar mass199.297 g·mol−1
3D model (JSmol)
SMILES
  • CNC(C)Cc1ccc2ccccc2c1
InChI
  • InChI=1S/C14H17N/c1-11(15-2)9-12-7-8-13-5-3-4-6-14(13)10-12/h3-8,10-11,15H,9H2,1-2H3
  • Key:BWWWOLYZMKACSB-UHFFFAOYSA-N

It acts as a releasing agent of serotonin, norepinephrine, and dopamine, with EC50 values of 13 nM, 34 nM, and 10 nM, respectively.[1]

Methamnetamine is illegal in Japan.[6]

See also

References
  1. Rothman RB, Partilla JS, Baumann MH, Lightfoot-Siordia C, Blough BE (April 2012). "Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters". The Journal of Pharmacology and Experimental Therapeutics. 341 (1): 251–62. doi:10.1124/jpet.111.188946. PMC 3364510. PMID 22271821.
  2. Youn, Dong-Hyun; Kim, Jin Mook; Hong, Young-ki; Park, Seo-In; Lee, Jin-Moo; Kim, Young-Hoon; Park, Chang Won; Kang, Mi Sun (April 2021). "Assessment of the abuse potential of methamnetamine in rodents: a behavioral pharmacology study". Psychopharmacology. 238 (8): 2155–2165. doi:10.1007/s00213-021-05840-9. ISSN 1432-2072. PMID 33811503. S2CID 232773019.
  3. Hong, Young-ki; Kim, Young-Hoon; Lee, Jin-Moo; Yoo, Hye Hyun; Choi, Sun-Ok; Kang, Mi Sun (April 2021). "Characterization of in vitro phase I metabolites of methamnetamine in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometry". International Journal of Legal Medicine. 135 (4): 1471–1476. doi:10.1007/s00414-021-02594-z. ISSN 1437-1596. PMID 33928430. S2CID 233451101.
  4. "Methamnetamine". WEDINOS.
  5. "Methamnetamine". New Synthetic Drugs Database.
  6. "指定薬物名称・構造式一覧（平成27年9月16日現在）" (PDF) (in Japanese). 厚生労働省. 16 September 2015. Retrieved 8 October 2015.
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